2018
DOI: 10.1016/j.brs.2017.10.017
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Sensory percepts induced by microwire array and DBS microstimulation in human sensory thalamus

Abstract: Producing consistent evoked perceptions across separate digits within sensory thalamus is a feasible concept and a compact alternative to somatosensory cortex microstimulation for prosthetic sensory feedback. This approach will require a multi-element low impedance electrode with a sufficient stimulation range to evoke variable intensities of perception and a predictable spread of contacts to engage separate digits.

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Cited by 30 publications
(25 citation statements)
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“…In the past, electrical intracortical microstimulation (ICMS) of the somatosensory cortex and stimulation of thalamic nuclei have been proposed as potential target sites for input of prosthetic sensory information [11][12][13][14][15][16][17][18] ; however, given the invasiveness of surgical procedures needed to implement these approaches in humans, alternative targets along the somatosensory pathway need to be explored for transmission of artificial sensory information to the brain.…”
mentioning
confidence: 99%
“…In the past, electrical intracortical microstimulation (ICMS) of the somatosensory cortex and stimulation of thalamic nuclei have been proposed as potential target sites for input of prosthetic sensory information [11][12][13][14][15][16][17][18] ; however, given the invasiveness of surgical procedures needed to implement these approaches in humans, alternative targets along the somatosensory pathway need to be explored for transmission of artificial sensory information to the brain.…”
mentioning
confidence: 99%
“…Lack of sensory feedback from a brain-controlled actuator or prosthetic device is a major hindrance to successful integration of the neuroprosthesis in activities of daily life and rehabilitative protocols (1)(2)(3). The somatosensory cortex (S1) and thalamus have been proposed as potential targets for neurostimulation that could produce naturalistic somatosensory percepts (4)(5)(6)(7)(8)(9)(10). However, stimulating these brain areas requires surgical implantation of deep intracranial electrodes -a procedure associated with significant risks.…”
Section: Mainmentioning
confidence: 99%
“…In electrophysiological studies, same electrode recording and stimulation would enable stimulus-response experiments at single neuron or small neuronal population level ( Shepherd et al, 2001 ; Houweling and Brecht, 2008 ; Krause et al, 2019 ). In deep brain stimulation (DBS), which provides therapy to various neurological diseases such as movement disorder ( Ackermans et al, 2006 ; Voges et al, 2007 ), depression ( Schlaepfer et al, 2014 ), and epilepsy ( Halpern et al, 2008 ), such technique would allow delicate micro-manipulation of complex neural circuits and monitoring feedback neural signals with high spatial resolution ( Vesper et al, 2002 ; Little et al, 2013 ; Priori et al, 2013 ; Salam et al, 2016 ; Swan et al, 2018 ). In cortical prostheses such as the hippocampal memory prosthesis, which aims to restore cognitive functions by replacing damaged brain regions ( Song et al, 2007 , 2009 ; Berger et al, 2011 ; Hampson et al, 2018 ), stimulating and recording from the same single neurons becomes vital for successful implementation of the single neuron-level, multi-input, and multi-output model-based microstimulation ( Deadwyler et al, 2018 ; Song et al, 2018 ).…”
Section: Introductionmentioning
confidence: 99%