Sensory percepts induced by microwire array and DBS microstimulation in human sensory thalamus

Swan, Brandon D.; Gasperson, Lynne B.; Krucoff, Max O.; Grill, Warren M.; Turner, Dennis A.

doi:10.1016/j.brs.2017.10.017

Cited by 30 publications

(25 citation statements)

References 52 publications

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“…In the past, electrical intracortical microstimulation (ICMS) of the somatosensory cortex and stimulation of thalamic nuclei have been proposed as potential target sites for input of prosthetic sensory information [11][12][13][14][15][16][17][18] ; however, given the invasiveness of surgical procedures needed to implement these approaches in humans, alternative targets along the somatosensory pathway need to be explored for transmission of artificial sensory information to the brain.…”

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confidence: 99%

A Brain to Spine Interface for Transferring Artificial Sensory Information

Yadav

Nicolelis

2020

Sci Rep

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Lack of sensory feedback is a major obstacle in the rapid absorption of prosthetic devices by the brain. While electrical stimulation of cortical and subcortical structures provides unique means to deliver sensory information to higher brain structures, these approaches require highly invasive surgery and are dependent on accurate targeting of brain structures. Here, we propose a semi-invasive method, Dorsal Column Stimulation (DCS) as a tool for transferring sensory information to the brain. Using this new approach, we show that rats can learn to discriminate artificial sensations generated by DCS and that DCS-induced learning results in corticostriatal plasticity. We also demonstrate a proof of concept brain-to-spine interface (BTSI), whereby tactile and artificial sensory information are decoded from the brain of an "encoder" rat, transformed into DCS pulses, and delivered to the spinal cord of a second "decoder" rat while the latter performs an analog-to-digital conversion during a sensory discrimination task. These results suggest that DCS can be used as an effective sensory channel to transmit prosthetic information to the brain or between brains, and could be developed as a novel platform for delivering tactile and proprioceptive feedback in clinical applications of brain-machine interfaces.

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confidence: 99%

A Brain to Spine Interface for Transferring Artificial Sensory Information

Yadav

Nicolelis

2020

Sci Rep

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“…Lack of sensory feedback from a brain-controlled actuator or prosthetic device is a major hindrance to successful integration of the neuroprosthesis in activities of daily life and rehabilitative protocols (1)(2)(3). The somatosensory cortex (S1) and thalamus have been proposed as potential targets for neurostimulation that could produce naturalistic somatosensory percepts (4)(5)(6)(7)(8)(9)(10). However, stimulating these brain areas requires surgical implantation of deep intracranial electrodes -a procedure associated with significant risks.…”

Section: Mainmentioning

confidence: 99%

Generating Artificial Sensations with Spinal Cord Stimulation in Primates and Rodents

Yadav¹,

Krucoff

et al. 2020

Preprint

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For patients who have lost sensory function due to a neurological injury such as spinal cord injury (SCI), stroke, or amputation, spinal cord stimulation (SCS) may provide a mechanism for restoring somatic sensations via an intuitive, non-visual pathway. We have previously shown that rats can learn to discriminate time-varying patterns of epidural SCS. Here we ran additional experiments in rats and conducted a new study in rhesus monkeys trained to discriminate patterns of epidural dorsal thoracic SCS. Based on these results, we constructed psychometric curves describing the relationship between different SCS parameters and the animal's ability to detect the presence of SCS and/or changes in its characteristics. We found that the stimulus detection threshold decreased with higher frequency, longer pulse-width, and increasing duration of SCS. Moreover, we found that monkeys were able to discriminate spatiotemporal patterns (i.e. variations in frequency and location) of SCS delivered through multiple electrodes. Additionally, the analysis of rat data showed that discrimination of SCS-induced sensations obeyed Weber's law of just noticeable differences. These findings suggest that by varying SCS intensity, temporal pattern and location different tactile and/or proprioceptive sensations can be evoked. As such, we posit that SCS can be used to provide intuitive sensory feedback in neuroprosthetic devices.

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“…In electrophysiological studies, same electrode recording and stimulation would enable stimulus-response experiments at single neuron or small neuronal population level ( Shepherd et al, 2001 ; Houweling and Brecht, 2008 ; Krause et al, 2019 ). In deep brain stimulation (DBS), which provides therapy to various neurological diseases such as movement disorder ( Ackermans et al, 2006 ; Voges et al, 2007 ), depression ( Schlaepfer et al, 2014 ), and epilepsy ( Halpern et al, 2008 ), such technique would allow delicate micro-manipulation of complex neural circuits and monitoring feedback neural signals with high spatial resolution ( Vesper et al, 2002 ; Little et al, 2013 ; Priori et al, 2013 ; Salam et al, 2016 ; Swan et al, 2018 ). In cortical prostheses such as the hippocampal memory prosthesis, which aims to restore cognitive functions by replacing damaged brain regions ( Song et al, 2007 , 2009 ; Berger et al, 2011 ; Hampson et al, 2018 ), stimulating and recording from the same single neurons becomes vital for successful implementation of the single neuron-level, multi-input, and multi-output model-based microstimulation ( Deadwyler et al, 2018 ; Song et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Stimulation and Recording of the Hippocampus Using the Same Pt-Ir Coated Microelectrodes

Elyahoodayan

Jiang

Lee³

et al. 2021

Front. Neurosci.

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Same-electrode stimulation and recording with high spatial resolution, signal quality, and power efficiency is highly desirable in neuroscience and neural engineering. High spatial resolution and signal-to-noise ratio is necessary for obtaining unitary activities and delivering focal stimulations. Power efficiency is critical for battery-operated implantable neural interfaces. This study demonstrates the capability of recording single units as well as evoked potentials in response to a wide range of electrochemically safe stimulation pulses through high-resolution microelectrodes coated with co-deposition of Pt-Ir. It also compares signal-to-noise ratio, single unit activity, and power efficiencies between Pt-Ir coated and uncoated microelectrodes. To enable stimulation and recording with the same microelectrodes, microelectrode arrays were treated with electrodeposited platinum-iridium coating (EPIC) and tested in the CA1 cell body layer of rat hippocampi. The electrodes’ ability to (1) inject a large range of electrochemically reversable stimulation pulses to the tissue, and (2) record evoked potentials and single unit activities were quantitively assessed over an acute time period. Compared to uncoated electrodes, EPIC electrodes recorded signals with higher signal-to-noise ratios (coated: 9.77 ± 1.95 dB; uncoated: 1.95 ± 0.40 dB) and generated lower voltages (coated: 100 mV; uncoated: 650 mV) for a given stimulus (5 μA). The improved performance corresponded to lower energy consumptions and electrochemically safe stimulation above 5 μA (>0.38 mC/cm2), which enabled elicitation of field excitatory post synaptic potentials and population spikes. Spontaneous single unit activities were also modulated by varying stimulation intensities and monitored through the same electrodes. This work represents an example of stimulation and recording single unit activities from the same microelectrode, which provides a powerful tool for monitoring and manipulating neural circuits at the single neuron level.

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Sensory percepts induced by microwire array and DBS microstimulation in human sensory thalamus

Cited by 30 publications

References 52 publications

A Brain to Spine Interface for Transferring Artificial Sensory Information

A Brain to Spine Interface for Transferring Artificial Sensory Information

Generating Artificial Sensations with Spinal Cord Stimulation in Primates and Rodents

Stimulation and Recording of the Hippocampus Using the Same Pt-Ir Coated Microelectrodes

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