Sensitivity to House‐dust Mites in Atopic Dermatitis

Induction of scratching behaviour and dermatitis in various strains of mice cohabiting with NC/Nga mice with chronic dermatitis

“…Even though acaricide could inhibit the development of dermatitis and scratching induction in NC mice, it has no therapeutic effect on skin inflammation in NC mice with severe dermatitis (unpublished observation). Dermatophagoides spp., common mites on humans, with the highest population among house dust mites, do not bite humans, but most patients with AD have high titres of specific IgE to Dermatophagoides mites 20 . Thus allergens of these mites were considered to be inhaled 21 or to penetrate the skin 22 of patients with AD.…”

A double‐blind controlled trial of hyposensitization to Dermatophagoides pteronyssinus in children with atopic eczema

“…Though occasional studies have indicated reduction in mite levels and clinical benefit [11], evidence that such measures substantially reduce either the house dust mite population or the prevalence of house dust mite antigen has not been convincing; nor do they generally appear to have been beneficial in terms of disease severity [12]. Properly controlled trials of such procedures have not been undertaken in atopic eczema, though open evaluations have been reported to demonstrate some improvement in patients' disease activity [13][14][15].…”

IgE and atopic dermatitis

“…Several clinical studies have supported a role for aeroallergens (house dust, house dust mite, grass pollen) in the pathogenesis of AD (13)(14)(15)(16)(17)(18)(19)(20).…”

“…The skin lesions of patients with AD, who were allergic to house dust, improved if they were removed from their houses and placed in allergien-free rooms (19). Patients with AD showed immediate type skin reactions to extracts made from their own houses and some patients could be cured by cleaning their houses (13). Long-term improvement of AD patients could be achieved by thoroughly cleaning the patients bedrooms (21).…”