A double‐blind controlled trial of hyposensitization to <i>Dermatophagoides pteronyssinus</i> in children with atopic eczema

Glover, Mary; Atherton, D.J.

doi:10.1111/j.1365-2222.1992.tb00145.x

Cited by 120 publications

(70 citation statements)

References 16 publications

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“…However, the clinical usefulness of allergen-specific immunotherapy for atopic dermatitis is controversial [3, 10]. Double-blind controlled trials have failed to show consistent efficacy of allergen-specific immunotherapy for the treatment of atopic dermatitis [3, 10]. The current controversy on the clinical usefulness of allergen-specific immunotherapy for atopic dermatitis is puzzling considering it is being regarded as one of the major treatment options for canine atopic dermatitis [17].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Although clinical usefulness of allergen-specific immunotherapy for the treatment of allergic asthma and allergic rhinitis has been demonstrated [9], its efficacy for atopic dermatitis is controversial [3, 10]. A histamine-γ-globulin complex (also named ‘histaglobin’) has been used in many countries to treat allergic diseases for more than 40 years [11,12,13], and it was shown to significantly improve atopic dermatitis in 1 randomized controlled study [11].…”

Section: Introductionmentioning

confidence: 99%

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Treatment of Atopic Dermatitis with a Combination of Allergen-Specific Immunotherapy and a Histamine-Immunoglobulin Complex

Nahm

Lee

Park

et al. 2008

Int Arch Allergy Immunol

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Background: Allergic responses to common environmental agents are believed to be involved in the development of atopic dermatitis, but clinical usefulness of allergen-specific immunotherapy in the treatment of atopic dermatitis is controversial. We performed a pilot study to evaluate the clinical usefulness of combined treatment with allergen-specific immunotherapy and a histamine-immunoglobulin complex in patients with atopic dermatitis. Methods: Twenty patients with atopic dermatitis and hypersensitivity to house dust mites whose clinical conditions had not been effectively controlled by current standard medical therapies were treated with a combination of allergen-specific immunotherapy using house dust mite extract and a histamine-immunoglobulin complex for 12 months. The primary efficacy outcome was the change in the standardized clinical severity scoring system for atopic dermatitis (SCORAD) values at 6 and 12 months in comparison with the values at baseline. Results: In 18 patients who completed all 12 months of treatment, the SCORAD values significantly decreased from 43.6 ± 15.9 at baseline to 27.8 ± 18.3 at 6 months and 18.3 ± 14.9 at 12 months (Wilcoxon signed-rank test, p < 0.001), and no significant systemic side effects were observed. Conclusions: In this uncontrolled pilot study, combined treatment with allergen-specific immunotherapy and a histamine-immunoglobulin complex resulted in significant clinical improvements in patients with atopic dermatitis. However, double-blind placebo-controlled studies are necessary to test the clinical usefulness of this modified allergen-specific immunotherapy for atopic dermatitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Treatment of Atopic Dermatitis with a Combination of Allergen-Specific Immunotherapy and a Histamine-Immunoglobulin Complex

Nahm

Lee

Park

et al. 2008

Int Arch Allergy Immunol

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“…En las últimas dos décadas, se han llevado a cabo varios estudios aleatorios controlados en los cuales se ha demostrado que un porcentaje importante de los pacientes con dermatitis atópica se puede beneficiar con esta terapia, aunque su impacto varía de acuerdo con la gravedad de la enfermedad (57)(58)(59)(60)(61). En un estudio en Medellín, Colombia, se observó que los pacientes con dermatitis moderada según la puntuación en el Scoring Atopic Dermatitis (SCORAD), tuvieron una mayor y más significativa reducción de los síntomas en comparación con el grupo placebo, así como un aumento significativo de la IgG4 (62) y una disminución en la capacidad de activación de los basófilos (25), lo que indicaría una disminución sostenida de la reacción inflamatoria.…”

Section: Dermatitis Atópicaunclassified

Inmunoterapia con alérgenos: mecanismos de acción, impacto terapéutico y socioeconómico. Consenso de la Asociación Colombiana de Alergias Asma e Inmunología

et al. 2016

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: idea central. Todos los autores participaron por igual en la redacción del manuscrito y la aprobaron la versión final. Las alergias constituyen un conjunto de enfermedades de gran prevalencia. Cuando los procesos alérgicos no se controlan, pueden poner en peligro la salud e, incluso, la vida de los pacientes y, además, su efecto económico y social es considerable. El objetivo de esta revisión es presentar un consenso práctico de la información científica disponible sobre el empleo de la inmunoterapia en las enfermedades alérgicas con la colaboración de varios institutos y universidades de Colombia, por solicitud de la Asociación Colombiana de Alergia, Asma e Inmunología. La revisión incluyó aspectos prácticos presentados desde el punto de vista de médicos generales, alergólogos, inmunólogos, internistas y pediatras con experiencia en el campo de las alergias. Con base en la evidencia científica actual a nivel nacional e internacional, se describió de forma detallada en qué consiste la inmunoterapia, sus indicaciones, contraindicaciones y sus beneficios para la salud, así como en el ámbito socioeconómico. Se concluyó que la inmunoterapia es efectiva y segura, y que, además, puede reducir sustancialmente el costo del tratamiento global de los pacientes alérgicos. Inmunoterapia con alérgenosPalabras clave: alérgenos, consenso, asma, anafilaxia, dermatitis, conjuntivitis, himenópteros, inmunoterapia, rinitis.doi: http://dx.doi.org/10.7705/biomedica.v36i3.3183 Allergen immunotherapy: Mechanisms of action, and therapeutic and socioeconomic impact Consensus of the Asociación Colombiana de Alergia, Asma e ImunologíaAllergies comprise a set of highly prevalent diseases. When allergic processes are not controlled, they can endanger patients' health and lives, and have an important economic and social impact. The aim of this paper is to present a practical consensus of the scientific evidence on the use of immunotherapy in allergic diseases. A collaborative review made by various institutes and universities in Colombia was carried out upon request of the Asociación Colombiana de Alergia, Asma e Imunología, led by general practitioners, allergists, immunologists, internists and paediatricians with experience in the field of allergies. As a result, based on current national and international scientific evidence, we describe in detail what immunotherapy is about, its indications, contraindications and its economic and health benefits.Conclusions show immunotherapy as a clinically effective and safe treatment, which can substantially reduce the cost of the overall treatment of allergic patients.

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“…Two controlled SCIT studies for dust mite allergic patients with AD have been published. 163,164 Long-term treatment with high dose SCIT produced statistically significant improvement in AD in both groups. One controlled SLIT study has shown skin improvement in dust mite allergic children with AD.…”

Section: Specific Immunotherapy (Sit)mentioning

confidence: 99%

Clinical correlations of recent developments in the pathogenesis of atopic dermatitis

Sehra

Tuana

Holbreich

et al. 2008

An. Bras. Dermatol.

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Atopic dermatitis is a chronic inflammatory skin disease with a steadily increasing prevalence affecting 10-20 % of infants and 1-3% of adults globally. It is often the first clinical manifestation of atopic disease preceding asthma and allergic rhinitis. Probably half of the children with atopic dermatitis develop some other form of atopic disease later in life. The pathogenesis involves a complex interplay of factors including genetic predisposition due to altered immune or skin barrier function, interactions with the environment such as food and allergen exposures, and infectious triggers of inflammation. In this review, we summarize the recent advances in understanding the contribution of different factors in the pathophysiology of atopic dermatitis and how insights provide new therapeutic potential for its treatment. Keywords: Asthma; Atopic Dermatitis, Eczema; Eosinophils; Genetics; Immunoglobulin E; Keratinocytes; Rhinitis, T-Lymphocytes Resumo: A dermatite atópica é uma doença cutânea inflamatória crônica cuja prevalência tem aumentado de forma constante, afetando 10-20% dos lactentes e 1-3% dos adultos em todo o mundo. Ela é freqüentemente a primeira manifestação clínica de doença atópica, precedendo a asma e a rinite alérgica. Provavelmente metade das crianças com dermatite atópica desenvolvem alguma

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A double‐blind controlled trial of hyposensitization to Dermatophagoides pteronyssinus in children with atopic eczema

Cited by 120 publications

References 16 publications

Treatment of Atopic Dermatitis with a Combination of Allergen-Specific Immunotherapy and a Histamine-Immunoglobulin Complex

Treatment of Atopic Dermatitis with a Combination of Allergen-Specific Immunotherapy and a Histamine-Immunoglobulin Complex

Inmunoterapia con alérgenos: mecanismos de acción, impacto terapéutico y socioeconómico. Consenso de la Asociación Colombiana de Alergias Asma e Inmunología

Clinical correlations of recent developments in the pathogenesis of atopic dermatitis

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