IgE and atopic dermatitis

Bruijnzeel-Koomen, C; Reysen, F van; Mudde, Geert C.

doi:10.1111/j.1365-2222.1991.tb01745.x

Cited by 9 publications

(4 citation statements)

References 47 publications

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“…One of the main features of allergic inflammation, including asthma, rhinitis, dermatitis, and conjunctivitis, is an intense eosinophil accumulation [16][17][18]. Treatment of rats or mice with selective ET A (BQ-123) or mixed ET A /ET B receptor antagonists (bosentan or SB209670) prevents the influx of eosinophils into bronchoalveolar lavage (BAL) fluid induced by instillation of Sephadex beads into the airways or by antigen challenge [19,20], suggesting a role for these peptides in pulmonary allergic inflammation and eosinophil migration.…”

Section: Introductionmentioning

confidence: 99%

Role of endothelins on lymphocyte accumulation in allergic pleurisy

Sampaio

Rae²,

Henriques

2000

Journal of Leukocyte Biology

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Endothelins participate in different aspects of inflammatory reactions, including edema formation and eosinophil accumulation in allergic reaction. In this study, we demonstrated a role for endogenous endothelins in eosinophil and T lymphocyte recruitment and cytokine secretion in a murine model of allergic inflammation. Intrathoracic stimulation with endothelin-1 triggered a neutrophil accumulation at 4 h, concomitant with an increase of CD4 ϩ and CD8 ϩ T lymphocyte populations. Antigen challenge in sensitized animals leads to an increase in eosinophil and mononuclear cell numbers at 24 h. Treatment with ET A receptor antagonist (BQ123) inhibited antigen-induced eosinophil and mononuclear cell migration, whereas the selective ET B receptor antagonist BQ-788 was ineffective. The latter effect of BQ-123 was due to inhibition of CD4 ϩ and CD8 ϩ T lymphocytes. Treatment with BQ-123 also inhibited interleukin-5 levels in the exudate and plasma as well as intracellular staining of interleukin-4, interleukin-5, and interferon-␥ in CD4 ϩ lymphocytes. These findings suggest that endogenous endothelins contribute to allergic inflammation by modulating lymphocyte recruitment and cytokine production.

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Section: Introductionmentioning

confidence: 99%

Role of endothelins on lymphocyte accumulation in allergic pleurisy

Sampaio

Rae²,

Henriques

2000

Journal of Leukocyte Biology

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“…Most atopic patients from this study also showed allergic relations to other proteins such as grasspollen, pet animals, etc., and it should be taken into account that in patients without dermatitis maximal FAP might occur with other allergens. There is no consensus on the correlation between the severity of dermatitis and the total serum IgE level [7,14], but there is some evidence for a relation between the occurrence of eczema and high Dtrp 2-specific IgE concentration [15]. Results of our study indicate that for this particular allergen, Der p 2, there might be a relation between FAP of Der p 2 and atopic dermatitis.…”

Section: Discussionmentioning

confidence: 65%

Relationship between facilitated allergen presentation and the presence of allergen-specific IgE in serum of atopic patients

Heijden

Neerven

Kapsenberg

1995

Clinical and Experimental Immunology

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SUMMARYAllergen presentation to allergen-specific T cells can be facilitated when IgE-allergen complexes are endocytosed by antigen-presenting cells (APC) after binding to the low-affinity FceR type II (CD23). Here we present a study on the relative capabilities of sera of atopic patients to mediate facilitated antigen presentation (FAP). To this aim FAP was studied in an in vitro model in which CD23-expressing Epstein-Barr virus (EBV)-B cells act as APC to T lymphocyte clones (TLC) that are specific for Der p 2, a major allergen of housedust mite Dermatophagoides pteronyssinus (Dp). Der p 2 is immune-complexed by preincubation in sera from atopic patients, containing allergenspecific IgE. If EBV-B cells are preincubated with these complexes before using the cells as APC, the allergen-specific TLC proliferate at 100-1000-fold lower allergen concentration than required for T cell activation after presentation of uncomplexed allergen. The relative capability of various sera to mediate FAP was correlated with total serum IgE, and especially with Der p 2-spccific serum IgE. In the model used, a high FAP capacity could be demonstrated only in sera with a total serum IgE concentration above approximately 2 /tg/ml or with Der p 2-specific IgE above approximately 100 ng/ml. Maximal FAP, i.e. the ability to induce maximal proliferation of the TLC, was obtained in the presence of more than ± 600 ng Dfr/»2-specificIgE/ml. At 100-600 ng/ ml Der p 2-specific IgE the level of FAP was correlated with the concentration of allergen-specific IgE, whereas at lower concentrations FAP was low or absent. All tested sera from eczema patients, all having serum anli-Der p 2-IgE concentrations > 600 ng/ml, showed a high FAP capacity, whereas all tested sera from atopic patients without eczema, which had serum a.n\\-Der p 2-IgE levels < 600 ng/ml, showed no or a low FAP capacity. The association of high FAP capacity with eczema may reflect a functional role of FAP in the pathogenesis of atopic dennatitis.

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“…Te relationship between serum IgE levels and the severity of cutaneous involvement in patients with AD with coexisting atopic respiratory disease was directly recognized in previous studies [23,31]. However, establishing a link between IgE levels and cutaneous involvement has been proven to be more challenging [22,[32][33][34].…”

Section: Discussionmentioning

confidence: 96%

The Combination of Serum Total IgE and Blood Eosinophil Levels as a Predictor of Response to Phototherapy Treatment in Patients with Atopic Dermatitis

Barzilai

Drousiotis

Dalal

et al. 2023

Dermatologic Therapy

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Atopic dermatitis (AD) is the most common chronic inflammatory skin disease affecting approximately 25% of all people worldwide at some point during their lifetime. Although total serum immunoglobulin E (IgE) and blood eosinophil levels are not elevated in all patients with AD, they have been shown associated with AD severity. This study aimed to investigate whether IgE and blood eosinophil levels correlate with the response to phototherapy treatment, which is a second-line treatment for moderate-to-severe AD, and therefore could be considered a readily available and reliable biomarker that could guide patient management. Eighty-two patients with AD who received phototherapy at the Sheba Medical Center were retrospectively evaluated for the following: demographic characteristics, serum IgE levels, blood eosinophils count, hospitalization duration, response to phototherapy, and requirement for systemic treatment. Response to phototherapy treatment was assessed by comparing the pre- and post-treatment Investigator’s Global Assessment score for each patient in relation to the aforementioned factors. The total IgE and eosinophil levels were found to be significantly higher in patients who did not respond to phototherapy ( p = 0.018 and p = 0.002 , accordingly). Serum values of 1780 IU/mL for IgE and 225.0 cells/μL for eosinophils showed maximum sensitivity and specificity as predictive values for treatment response. In conclusion, this study found that high total serum IgE levels and eosinophilia were correlated with a low response to phototherapy. These results suggest that escalating treatment is recommended for patients presenting these clinical features.

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IgE and atopic dermatitis

Cited by 9 publications

References 47 publications

Role of endothelins on lymphocyte accumulation in allergic pleurisy

Role of endothelins on lymphocyte accumulation in allergic pleurisy

Relationship between facilitated allergen presentation and the presence of allergen-specific IgE in serum of atopic patients

The Combination of Serum Total IgE and Blood Eosinophil Levels as a Predictor of Response to Phototherapy Treatment in Patients with Atopic Dermatitis

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