Sensitivity enhancement of potassium ion (K+) detection based on graphene field-effect transistors with surface plasma pretreatment

Yuan, Qilong; Wu, Sudong; Wang, Hongzhi; Liu, Xiangqi; Gao, Jingqing; Cui, Naiyuan; Guo, Pei; Lai, Guosong; Wei, Qiuping; Yang, Minghui; Su, Weitao; Li, He; Jiang, Nan; Fu, Li; Dang, Dai; Lin, Cheng‐Te; Chee, Kuan W. A.

doi:10.1016/j.snb.2019.01.058

Cited by 43 publications

(17 citation statements)

References 55 publications

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“…Wearable electrolytic sensors with the employment of varied graphene-based structures, such as sheets, flakes, 3D porous, field-effect transistors and nanocomposites, are capable of continuous monitoring of pH (Xuan et al, 2018a; Dang et al, 2019), potassium (He et al, 2017; Yuan et al, 2019), sodium (Ruecha et al, 2017) and chloride (Tseng et al, 2018), etc. The presence of graphene increases the hydrophobicity of the electrode surface, provides a high surface area, excellent conductivity, electrocatalytic activity and accelerates the electron transportation during ion exchange between an electrode and the solution.…”

Section: Current Applicationsmentioning

confidence: 99%

Graphene-Based Sensors for Human Health Monitoring

et al. 2019

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Since the desire for real-time human health monitoring as well as seamless human-machine interaction is increasing rapidly, plenty of research efforts have been made to investigate wearable sensors and implantable devices in recent years. As a novel 2D material, graphene has aroused a boom in the field of sensor research around the world due to its advantages in mechanical, thermal, and electrical properties. Numerous graphene-based sensors used for human health monitoring have been reported, including wearable sensors, as well as implantable devices, which can realize the real-time measurement of body temperature, heart rate, pulse oxygenation, respiration rate, blood pressure, blood glucose, electrocardiogram signal, electromyogram signal, and electroencephalograph signal, etc. Herein, as a review of the latest graphene-based sensors for health monitoring, their novel structures, sensing mechanisms, technological innovations, components for sensor systems and potential challenges will be discussed and outlined.

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Section: Current Applicationsmentioning

confidence: 99%

Graphene-Based Sensors for Human Health Monitoring

et al. 2019

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“…The key is to improve the sensitivity and stability of the Gr-FET biosensors for the practical applications widely, as well as the understanding of sensing mechanisms. The channel surface modification or functionalization, such as graphene patterning [ 34 ], surface plasma pretreatment [ 35 ], Au nanoparticles [ 36 ], 1-pyrenebutyric acid succinimidyl ester (PBASE) [ 37 ], lipid membrane [ 38 ], PEG [ 39 ] and aptamers [ 40 ] etc., was studied to improve the sensitivity and stability of Gr-FET based biosensors for different biomarkers detection. The molybdenum disulfide/graphene nanostructure-based field-effect transistor biosensor was constructed and studied for sensitive RNA detection with donor effect dominated mechanism [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide-graphene Van der Waals heterostructure transistor biosensor for SARS-CoV-2 protein detection

Gao

Chu

Han

et al. 2022

Talanta

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The current outbreaking of the coronavirus SARS-CoV-2 pandemic threatens global health and has caused serious concern. Currently there is no specific drug against SARS-CoV-2, therefore, a fast and accurate diagnosis method is an urgent need for the diagnosis, timely treatment and infection control of COVID-19 pandemic. In this work, we developed a field effect transistor (FET) biosensor based on graphene oxide-graphene (GO/Gr) van der Waals heterostructure for selective and ultrasensitive SARS-CoV-2 proteins detection. The GO/Gr van der Waals heterostructure was in-situ formed in the microfluidic channel through π-π stacking. The developed biosensor is capable of SARS-CoV-2 proteins detection within 20 min in the large dynamic range from 10 fg/mL to 100 pg/mL with the limit of detection of as low as ∼8 fg/mL, which shows ∼3 × sensitivity enhancement compared with Gr-FET biosensor. The performance enhancement mechanism was studied based on the transistor-based biosensing theory and experimental results, which is mainly attributed to the enhanced SARS-CoV-2 capture antibody immobilization density due to the introduction of the GO layer on the graphene surface. The spiked SARS-CoV-2 protein samples in throat swab buffer solution were tested to confirm the practical application of the biosensor for SARS-CoV-2 proteins detection. The results indicated that the developed GO/Gr van der Waals heterostructure FET biosensor has strong selectivity and high sensitivity, providing a potential method for SARS-CoV-2 fast and accurate detection.

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“…The nucleation of AuNPs on c-CNTs was formed in situ through the reduction of HAuCl 4 by NaBH 4 , and the MIP film was coated onto the surface of c-CNTs/AuNPs/GCE using the thermal polymerization method. Besides CNTs, graphene is an alternative to the fabrication of carbon/metal nanocomposites and carbon/metal oxide nanocomposites [ 24 , 29 , 30 , 31 , 32 ]. Selvi et al, synthesized zinc oxide with reduced graphene oxide (ZnO/rGO) via a hydrothermal method to propose a CAP sensor with a linear range of 0.19–2857.3 μM and a detection limit of 0.13 μM [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Intertwined Carbon Nanotubes and Ag Nanowires Constructed by Simple Solution Blending as Sensitive and Stable Chloramphenicol Sensors

Zhu

et al. 2021

Sensors

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Chloramphenicol (CAP) is a harmful compound associated with human hematopathy and neuritis, which was widely used as a broad-spectrum antibacterial agent in agriculture and aquaculture. Therefore, it is significant to detect CAP in aquatic environments. In this work, carbon nanotubes/silver nanowires (CNTs/AgNWs) composite electrodes were fabricated as the CAP sensor. Distinguished from in situ growing or chemical bonding noble metal nanomaterials on carbon, this CNTs/AgNWs composite was formed by simple solution blending. It was demonstrated that CNTs and AgNWs both contributed to the redox reaction of CAP in dynamics, and AgNWs was beneficial in thermodynamics as well. The proposed electrochemical sensor displayed a low detection limit of up to 0.08 μM and broad linear range of 0.1–100 μM for CAP. In addition, the CNTs/AgNWs electrodes exhibited good performance characteristics of repeatability and reproducibility, and proved suitable for CAP analysis in real water samples.

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Sensitivity enhancement of potassium ion (K+) detection based on graphene field-effect transistors with surface plasma pretreatment

Cited by 43 publications

References 55 publications

Graphene-Based Sensors for Human Health Monitoring

Graphene-Based Sensors for Human Health Monitoring

Graphene oxide-graphene Van der Waals heterostructure transistor biosensor for SARS-CoV-2 protein detection

Intertwined Carbon Nanotubes and Ag Nanowires Constructed by Simple Solution Blending as Sensitive and Stable Chloramphenicol Sensors

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