Sensitivity and Specificity of Detecting Polypoidal Choroidal Vasculopathy With en Face Optical Coherence Tomography and Optical Coherence Tomography Angiography

Abstract

Sensitivity of detecting PCV was low using structural en face OCT and OCTA but specificity was high. Indocyanine green angiography remains the gold standard for PCV detection.

Polypoidal Choroidal Vasculopathy Diagnosis and Neovascular Activity Evaluation Using Optical Coherence Tomography Angiography

“…A meta-analysis done recently by Wang et al revealed a high diagnostic detection rate of polyps and BVN by OCTA in PCV, and the detection rate of BVN was higher than that of polyps [16]. However, although OCTA has greatly facilitated the detection of BVN by providing a thorough description of their structure [17], polypoidal lesions were poorly visualized on en face SS-OCTA and some reports suggest that they may be missed with this technique because of undetectable blood flow [18,19]. However, observation from other studies that use SS-OCTA has suggested a higher sensitivity in the detection of polypoidal lesions [20].…”

Optical coherence tomography angiography analysis of aneurismal type 1 neovascularization in a cohort of white patients

“…Thus, B-scan OCTA is superior to en face OCTA in the diagnosis of AT1. 25 However, the inter-grader agreement was low for BVN morphology and insignificant for polypoidal lesion morphology and type of flow signal, so our classification method is an unreliable approach, especially for polyps.…”

Detection Rate and Diagnostic Value of Optical Coherence Tomography Angiography in the Diagnosis of Polypoidal Choroidal Vasculopathy: A Systematic Review and Meta-Analysis

“…After excluding 643 records by screening the titles and abstracts, a total of 63 manuscripts were fully examined (see Figure 1). We ultimately included 20 studies [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] (640 eyes, 563 PCV eyes) for meta-analysis (see Table 1). We included 20 studies [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] reporting the polyp detection rate, 15 studies [10-12, 14, 15, 17-23, 25, 28, 29] reporting the BVN detection rate, and 4 articles [10,11,17,21] (6 studies) reporting the sensitivity and specificity of OCTA and ICGA for diagnosing PCV from wAMD eyes.…”

“…Cheung et al [10] observed unequally distributed blood ow signals in a polyp on di erent OCTA cross-sections. de Carlo et al [11] hypothesized that polyps may be too small to be detected on OCTA or covered by BVN blood ow signals, resulting in an unclear polyp structure.…”