Sensitive biosensors based on topological insulator Bi2Se3 and peptide

Jiang, Yujiu; Zhu, Peng; Zhao, Jinge; Li, Shanshan; Wu, Yetong; Xiong, Xiaolu; Zhang, Xu; Liu, Yuxiang; Bai, Jiangyue; Wang, Zihang; Xu, Shiqi; Wang, Minxuan; Song, Tinglu; Wang, Zhiwei; Wang, Weizhi; Han, Junfeng

doi:10.1016/j.aca.2022.340655

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…These advantages lead to better specificity, stability, and selectivity of the sensor. The LOD of the method was 1.07 × 10 -11 mg.mL -1 , and the linear detection range was 3.6 × 10 -10 mg.mL -1 to 3.6 × 10 -5 mg.mL -1 99 (Fig. 5 B) .…”

Section: Detection Methodsmentioning

confidence: 93%

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Recent Advancement of PD-L1 Detection Technologies and Clinical Applications in the Era of Precision Cancer Therapy

Zhang¹,

Wu²,

Zhao³

et al. 2023

J. Cancer

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Programmed death-1 is a protein found on the surface of immune cells that can interact with its ligand, programmed death-ligand 1 (PD-L1), which is expressed on the plasma membrane, the surface of secreted cellular exosomes, in cell nuclei, or as a circulating soluble protein. This interaction can lead to immune escape in cancer patients. In clinical settings, PD-L1 plays an important role in tumor disease diagnosis, determining therapeutic effectiveness, and predicting patient prognosis. PD-L1 inhibitors are also essential components of tumor immunotherapy. Thus, the detection of PD-L1 levels is crucial, especially in the era of precision cancer therapy. In recent years, innovations have been made in traditional immunoassay methods and the development of new immunoassays for PD-L1 detection. This review aims to summarize recent research progress in tumor PD-L1 detection technology and highlight the clinical applications of PD-L1.

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Section: Detection Methodsmentioning

confidence: 93%

“…(D) Linear relationship between the peak currents and the logarithmic values of exosome concentrations. (A and B cited from reference 99 , with permission by Elsevier; C and D cited from reference 103 , with permission by ACS.)…”

Section: Figurementioning

confidence: 99%

Recent Advancement of PD-L1 Detection Technologies and Clinical Applications in the Era of Precision Cancer Therapy

Zhang¹,

Wu²,

Zhao³

et al. 2023

J. Cancer

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“…In particular, Bi 2 Se 3 has a single Dirac cone on its surface states, and the electrons on this unique topological surface state can realize high-speed and low-dissipation electron transmission. − Bi 2 Se 3 is a critical rival for HOPG, as the topological surface states ensure a 2D Dirac surface surrounding the bulk material, while in HOPG, it is only observed at the atomic monolayer (graphene) . These properties make Bi 2 Se 3 reliable for DNA assembly and sensitive biosensors. − However, research about the assembly behavior of DNA molecules on the Bi 2 Se 3 surface and biosensing application is scarce. − This is probably because the reported Bi 2 Se 3 nanoparticles and nanosheets synthesized by the solvothermal and hydrothermal methods − have many defects and boundaries.…”

Section: Introductionmentioning

confidence: 99%

Ordered Assembly of DNA on Topological Insulator Bi₂Se₃ and Octadecylamine for a Sensitive Biosensor

et al. 2023

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Controlling the assembly of DNA in order on a suitable electrode surface is of great significance for biosensors and disease diagnosis, but it is full of challenges. In this work, we creatively assembled DNA on the surface of octadecylamine (ODA)-modified topological insulator (Tls) Bi 2 Se 3 and developed an electrochemical biosensor to detect biomarker DNA of coronavirus disease 2019 (COVID-19). A high-quality Bi 2 Se 3 sheet was obtained from a single crystal synthesized in our lab. A uniform ODA layer was coated in argon by chemical vapor deposition (CVD). We observed and analyzed the assembly and mechanism of single-strand DNA (ssDNA) and double-strand DNA (dsDNA) on the Bi 2 Se 3 surface through atomic force microscopy (AFM) and molecular dynamics (MD) simulations. The electrochemical signal revealed that the biosensor based on the DNA/ODA/Bi 2 Se 3 electrode has a wide linear detection range from 1.0 × 10 −12 to 1.0 × 10 −8 M, with the limit of detection as low as 5 × 10 −13 M. Bi 2 Se 3 has robust surface states and improves the electrochemical signal-to-noise ratio, while the uniform ODA layer guides high-density ordered DNA, enhancing the sensitivity of the biosensor. Our work demonstrates that the ordered DNA/ODA/Bi 2 Se 3 electrode surface has great application potential in the field of biosensing and disease diagnosis.

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Rational Design of Bio‐Inspired Peptide Electronic Materials toward Bionanotechnology: Strategies and Applications

Zhao,

Liu,

Tong

et al. 2024

Adv Funct Materials

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Biologically inspired peptide‐based materials, as novel charge transport materials, have gained increasing interest in bioelectronics due to their remarkable electrical properties and inherent biocompatibility. Extensive studies have shown that peptides can self‐assemble into a variety of hierarchical nanostructures with unique physical properties through supramolecular interactions. Therefore, peptide‐based materials hold great promise for applications in emerging electronic fields such as sensing, energy harvesting, energy storage, and electronic transmission. Herein, this work proposes a review article to summarize the rational design and research progress of peptide‐based materials and devices in bioelectronics. This work first introduces the design strategies and assembly mechanism for constructing high‐performance peptide‐based electronic materials and devices. In the following part, the applications of peptide‐based electronic materials and devices are systematically classified and discussed, including sensors, piezoelectric nanogenerators, electrodes, and semiconductors. Finally, the remaining challenges and future perspectives of peptide‐based bioelectronic materials and devices are presented. This work believes that this review will provide inspiration and guidance for the design and development of innovative peptide‐based smart materials in the field of bioelectronics.

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Sensitive biosensors based on topological insulator Bi2Se3 and peptide

Cited by 5 publications

References 48 publications

Recent Advancement of PD-L1 Detection Technologies and Clinical Applications in the Era of Precision Cancer Therapy

Recent Advancement of PD-L1 Detection Technologies and Clinical Applications in the Era of Precision Cancer Therapy

Ordered Assembly of DNA on Topological Insulator Bi₂Se₃ and Octadecylamine for a Sensitive Biosensor

Rational Design of Bio‐Inspired Peptide Electronic Materials toward Bionanotechnology: Strategies and Applications

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Sensitive biosensors based on topological insulator Bi2Se3 and peptide

Cited by 5 publications

References 48 publications

Recent Advancement of PD-L1 Detection Technologies and Clinical Applications in the Era of Precision Cancer Therapy

Recent Advancement of PD-L1 Detection Technologies and Clinical Applications in the Era of Precision Cancer Therapy

Ordered Assembly of DNA on Topological Insulator Bi2Se3 and Octadecylamine for a Sensitive Biosensor

Rational Design of Bio‐Inspired Peptide Electronic Materials toward Bionanotechnology: Strategies and Applications

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Product

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Ordered Assembly of DNA on Topological Insulator Bi₂Se₃ and Octadecylamine for a Sensitive Biosensor