Sensitive bioassay for the simultaneous determination of pseudoephedrine and cetirizine in human plasma by liquid-chromatography–ion trap spectrometry

Simultaneous determination of triprolidine and pseudoephedrine in human plasma by liquid chromatography–ion trap mass spectrometry

“…Pseudoephedrine has been determined in plasma or in formulation using several techniques like LC-MS/MS [6,7], simultaneously with other drugs by LC-ion trap-MS [8,9], HPLC-UV [10] HPLC-RF [11], micellar electrokinetic chromatography [12]. The limit of quantitation of pseudoephedrine ranged from 1.25 to 10.0 ng/mL in these methods.…”

Comparison of HPLC and CE methods for the determination of cetirizine dihydrochloride in human plasma samples

“…A high-performance liquid chromatography (HPLC) with ultraviolet detection (UV) is the most widely used technique (Macek et al, 1999;Choi et al, 2000a, b;Kim et al, 2005;Zaater et al, 2000;Moncrieff, 1992;Jelinska et al, 2000Jelinska et al, , 2001Paw et al, 2002;Arayne et al, 2005;Bajerski et al, 2005;El Walily et al, 1998;Jaber et al, 2004;Nagaralli et al, 2003;Likar et al, 2005;Rosseel and Lefebvre, 1991) or liquid chromatography with spectrometric detection (LC-MS/MS) (Gergov et al, 2001;Gupta et al, 2005;de Jager et al, 2002;Rudaz et al, 2003;Song et al, 2005;Tan et al, 2006). Previously published methods included also gas chromatography (GC) (Baltes et al, 1988), high-performance thin-layer chromatography (HPTLC) (Makhija and Vavia, 2001;Pandya et al, 1996), electrooxidation (Güngör, 2004), spectrophotometric (El Walily et al, 1998;Mahgoub et al, 2003;Gowda et al, 2001;Basavaiah and Charan, 2002;Basavaiah et al, 1999;Gazy et al, 2002), titrimetric technique (Basavaiah and Charan, 2002) for cetirizine determination and assay based on cetirizine-tetraphenylborate ion-pair analysis (Shoukry et al, 1999).…”

“…A literature survey reveals that the majority of the papers describe the measurement in pharmaceutical formulations (Jelinska et al, 2000(Jelinska et al, , 2001Paw et al, 2002;Arayne et al, 2005;Bajerski et al, 2005;El Walily et al, 1998;Jaber et al, 2004;Nagaralli et al, 2003;Likar et al, 2005;Rudaz et al, 2003;Makhija et al, 2001;Güngör, 2004;Mahgoub et al, 2003;Gowda et al, 2001;Basavaiah and Charan, 2002;Basavaiah et al, 1999;Gazy et al, 2002;Shoukry et al, 1999). There are only a few reports on the cetirizine analysis in human (Macek et al, 1999;Kim et al, 2005;Nagaralli et al, 2003;de Jager et al, 2002;Song et al, 2005;Tan et al, 2006;Baltes et al, 1988;Pandya et al, 1996) or animal plasma samples (Choi et al, 2000a;Gupta et al, 2005), which have been based on HPLC following some form of liquid-liquid extraction (LLE) (Macek et al, 1999;Choi et al, 2000a;Kim et al, 2005;Nagaralli et al, 2003;Gupta et al, 2005;de Jager et al, 2002;Tan et al, 2006) or solidphase extraction (SPE) (Song et al, 2005). Some methods have been described for quantitation of cetirizine also in serum (Zaater et al, 2000;Moncrieff, 1992), blood …”

Liquid chromatography tandem mass spectrometry method for simultaneous determination of metoprolol tartrate and ramipril in human plasma

“…Complete chromatographic separation of MT and IS was not achieved under the set analytical conditions. However due to high selectivity of tandem MS, complete chromatographic separation is not necessary any more [33]. The main advantage of this method is that a relatively large number of samples can be analysed in short time thus increasing the output.…”