Sensitive and Selective Electrochemical Detection of Epirubicin as Anticancer Drug Based on Nickel Ferrite Decorated with Gold Nanoparticles

Abstract

The accurate and precise monitoring of epirubicin (EPR), one of the most widely used anticancer drugs, is significant for human and environmental health. In this context, we developed a highly sensitive electrochemical electrode for EPR detection based on nickel ferrite decorated with gold nanoparticles (Au@NiFe2O4) on the screen-printed electrode (SPE). Various spectral characteristic methods such as Fourier transform infrared spectra (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV-Vis), energy-dispersive X-ray spectroscopy (EDX) and electrochemical impedance spectroscopy (EIS) were used to investigate the surface morphology and structure of the synthesized Au@NiFe2O4 nanocomposite. The novel decorated electrode exhibited a high electrocatalytic activity toward the electrooxidation of EPR, and a nanomolar limit of detection (5.3 nM) was estimated using differential pulse voltammetry (DPV) with linear concentration ranges from 0.01 to 0.7 and 0.7 to 3.6 µM. The stability, selectivity, repeatability reproducibility and reusability, with a very low electrode response detection limit, make it very appropriate for determining trace amounts of EPR in pharmaceutical and clinical preparations.

A sensitive voltammetric sensor for specific recognition of vitamin C in human plasma based on MAPbI3 perovskite nanorods

“…Before being put into the electrochemical cell, the samples were diluted to a certain concentration using B-R buffer at pH 7.0. [14]. 202), (004), (220) lattice planes of the tetragonal phase perovskite, respectively [22][23][24].…”

“…Although a variety of analytical methods are utilized to determine AA, including spectroscopic [1], chromatographic [2,3], the electrochemical methods have been widely performed in recent years [4][5][6][7][8] because of their rapid response, high sensitivity, good stability, superior selectivity, and costeffectiveness [9][10][11]. However, enhancing electrochemical performance in real samples necessitates the development of well-defined chemical structures and porous nanomaterials [12][13][14]. Recently, there is a big jump in fine-tuning the properties of nanomaterials and utilizing them in various applications [15][16][17].…”

Silica Nanochannel Array Film Supported by ß-Cyclodextrin-Functionalized Graphene Modified Gold Film Electrode for Sensitive and Direct Electroanalysis of Acetaminophen

“…Electrochemical sensors have attracted much attention owing to their high sensitivity, simple operation, and no need of expensive instruments ( Bollella et al, 2017 ; Cesewski and Johnson, 2020 ; Bagheri et al, 2021 ; Mehmandoust et al, 2021 ; Min et al, 2021 ; Karimi-Maleh et al, 2022 ). However, direct electrochemical analysis of complex samples is challenging because of anti-fouling or anti-interference from the complicated matrix ( Yan et al, 2016 ; Lu et al, 2018 ).…”

An experimental and theoretical approach to electrochemical sensing of environmentally hazardous dihydroxy benzene isomers at polysorbate modified carbon paste electrode

“…Among all the electroanalytical methods, voltammetry is one of the widely adopted instrumental techniques used for the electroanalysis of various electroactive molecules 1 . The credentials of these voltammetric techniques owing to its portability, simplicity, inexpensive instrument cost, rapid response, high sensitivity and selectivity 2 , 3 . Over the past few decades, the electroanalytical researchers used unmodified and/or chemically modified carbonaceous working electrodes, such as; carbon paste 4 , 5 , carbon nanotube paste 6 , 7 , graphite pencil 8 , 9 , glassy carbon 10 , and screen-printed carbon electrode 11 for the determination of variety of electroactive molecules.…”