A sensitive voltammetric sensor for specific recognition of vitamin C in human plasma based on MAPbI3 perovskite nanorods

Abstract

A novel and sensitive electrode was suggested for the rapid determination of ascorbic acid (AA) using a glassy carbon electrode (GCE) modified with synthesized MAPbI3 and L-cys (L-cys/MAPbI3/GCE). Determination of ascorbic acid as an important component of the human diet due to help in decreasing blood pressure and improving endothelial function is crucial. The synthesized MAPbI3 was characterized by different methods, including transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD). The fabricated electrode exhibited superior electrical conductivity and fast electron transfer kinetics. The results illustrated that the developed electrode had an outstanding electrocatalytic activity towards the oxidation of AA in 0.1 M Britton–Robinson buffer(B-R) as a supporting electrolyte. The modified electrode demonstrated a linear range in differential pulse voltammetry of 0.02–11.4 µM with a low detection limit of 8.0 nM for ascorbic acid. It can be stated that the proposed sensor can be successfully applied to the determination of ascorbic acid in human plasma samples.

Fabrications of electrochemical sensors based on carbon paste electrode for vitamin detection in real samples

“…Electrochemical voltammetric methods are very promising for detecting VC in real samples. Here, some important works on developing sensors to detect VC in real samples using modified CPE will be presented [16][17][18][19].…”

Electrochemical detection of folic acid using a modified screen printed electrode

“…In recent years, modified electrodes have had many applications in various fields, including sensing, electrocatalysis, fuel cells, batteries and supercapacitors [36][37][38][39][40][41][42][43][44][45][46][47][48]. Chemical modification of electrodes with various materials such as nanomaterials, single molecular, multi-molecular, ionic, and polymeric components provides electrocatalytic properties in terms of increasing active surface area and accelerating electron transfer kinetics, which is beneficial for electrochemical sensing applications [49][50][51][52][53][54][55][56][57][58][59][60][61].…”

A sensitive and simple electrochemical technique for detecting ascorbic acid content in pharmaceutical and biological compounds

“…Their unique properties, such as physical, chemical, biological, optical, and magnetic properties, nanoscale materials have high surface/volume ratios that facilitate the recognition of molecules and contribute to the enhanced signal transmission between the interface and the target molecule. Hence, many research efforts have been devoted to the modification of electrodes by nanomaterials to improve analytical performance [45][46][47][48][49][50][51][52][53].…”