Senescence Effects of Angelica sinensis Polysaccharides on Human Acute Myelogenous Leukemia Stem and Progenitor Cells

Li, Jun; Xu, Chunyan; Cai, Shi-Zhong; Zhou, Yue; Li, Jing; Jiang, Rong; Wang, Yaping

doi:10.7314/apjcp.2013.14.11.6549

Cited by 23 publications

(11 citation statements)

References 35 publications

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“…Hematologic malignancies are a common disease in Asian Pacific areas (Feng et al, 2013;Jiang et al, 2013;Karami et al, 2013;Khodabandehloo et al, 2013;Kooshyar et al, 2013;Li et al, 2013;Liu et al, 2013;Ozbas-Gerceker et al, 2013;Qin et al, 2013;Shan et al, 2013). As our present study confirmed, the level of serum ferritin of patients with hematologic malignancies was significantly increased.…”

Section: Discussionsupporting

confidence: 78%

Elevated Serum Ferritin Levels in Patients with Hematologic Malignancies

Zhang

Su²,

Hu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 78%

Elevated Serum Ferritin Levels in Patients with Hematologic Malignancies

Zhang

Su²,

Hu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…As the initial extraction of Angelica sinensis , ASP has been reported to have beneficial effects in many diseases, including breast cancer, 17 liver cancer, 18 and acute myelogenous leukemia. 19 Additionally, ASP has the ability to improve the memory impairment in rat, as well as inhibit the development of brain senility. 20 In our study, MWM test confirmed that ASP could shorten the escape latencies, increase the activity time in platform quadrant and quadrant crossing times, suggesting its role in ameliorating spatial learning and memory deficiency in Aβ 25–35 -induced AD rats.…”

Section: Discussionmentioning

confidence: 99%

Angelica polysaccharide ameliorates memory impairment in Alzheimer’s disease rat through activating BDNF/TrkB/CREB pathway

Zhu

2019

Exp Biol Med (Maywood)

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This study aimed to investigate the effect of Angelica sinensis polysaccharides (ASP) on Alzheimer’s disease (AD) and its underlying mechanisms. In our study, we build the AD model by injecting Aβ25–35. Morris water maze (MWM) was applied to investigate learning and memory. Moreover, neurotransmitters, free radical, and inflammatory factors were also measured. Pathological change and neuronal death in hippocampus CA1, CA3, and DG region were detected by HE staining and Nissl staining. The neuronal apoptosis was detected by TUNEL. The expressions of caspase-3, Bcl-2 and Bax were measured by immunohistochemistry and Western blot. The expressions of BDNF, TrkB, p-Akt, Akt, p-CREB, and CREB were measured by Western blot. Our results showed that ASP could ameliorate spatial learning and memory deficiency in AD rats. ASP decreased AchE level and increased the levels of Ach and chAT in AD rats. ASP could increase the activity of SOD and CAT, decrease MDA activity, and inhibit the expression levels of inflammatory factors and neurons apoptosis in AD rats. Pathological change of hippocampus CA1, CA3, and DG region was ameliorated by ASP. In addition, the effects of ASP were reversed by K252a (TrkB inhibitor). Our study demonstrated that ASP could ameliorate memory impairment in AD rat through activating BDNF/TrkB/CREB pathway. Impact statement The present study demonstrated that ASP could ameliorate memory impairment through regulation of the balance of neurotransmitters, free radical metabolism, inflammation, and neurons apoptosis. Moreover, the mechanism of ASP on memory impairment may be related to BDNF/TrkB/CREB pathway in AD. Our research provides an innovatively regulatory mechanism about the ASP in AD rat and points a new way to the treatment of AD.

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“…The potential mechanism of ASP-induced cell senescence was closely correlated to the upregulation of p53, p16, p21, and Rb genes, the changes of related cell cycle regulatory proteins P16, P21, cyclin E and Cell Cycle Dependent Kinase 4, telomere wear, and inhibition of telomerase activity. 63 ASP could suppress the proliferation of chronic myeloid leukemia K562 cells, and its mechanism had association with the induction of erythroid differentiation. In the process of erythroid differentiation of K562 cells induced by ASP, the results suggested that the JAK2/STAT5 signal played an indispensable role in erythroid differentiation of human myeloid leukemia cell line K562 induced by ASP.…”

Section: Antitumor Activitymentioning

confidence: 96%

The Bioactivities and Potential Clinical Values of Angelica Sinensis Polysaccharides

et al. 2021

Natural Product Communications

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Angelica sinensis Radix (ASR), one of the most commonly used traditional Chinese medicines, contains many chemical components such as polysaccharides, volatile oil, flavonoids, amino acids, and organic acids, among which polysaccharides play an indispensable role in the therapeutic effect of ASR. A. sinensis polysaccharide (ASP) has many biological activities, for instance, hematopoietic, anti-tumor, and liver protection, which are closely related to the treatment of human diseases such as chronic anemia, leukemia, and diabetes. In addition, there are excellent application prospects for drug delivery in nanoparticles. This paper reviews the chemical compositions, extraction methods, biological activity, action mechanism, potential clinical applications, nanoparticles, and research prospect of ASP from 2010 to 2020, so as to provide references for its further development.

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Senescence Effects of Angelica sinensis Polysaccharides on Human Acute Myelogenous Leukemia Stem and Progenitor Cells

Cited by 23 publications

References 35 publications

Elevated Serum Ferritin Levels in Patients with Hematologic Malignancies

Elevated Serum Ferritin Levels in Patients with Hematologic Malignancies

Angelica polysaccharide ameliorates memory impairment in Alzheimer’s disease rat through activating BDNF/TrkB/CREB pathway

The Bioactivities and Potential Clinical Values of Angelica Sinensis Polysaccharides

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