Semipermeable glove membranes–effects on skin barrier repair following SLS irritation

Abstract

The results support the hypothesis that semipermeable materials improve barrier recovery rates by providing an optimized water vapour gradient during the healing process. This underlines the unique benefit of semipermeable gloves in the prevention of occupational skin disease: (i) by minimizing glove-induced irritation and (ii) by enhancing barrier recovery through protective glove materials at the work place in cases of pre-existing minor irritant dermatitis.

Epidermal Barrier Treatments Based on Vernix Caseosa

“…The recovery for SP, FO and NO in tape-stripped human skin is consistent with our previous reports [26,40] and accounts that SPs facilitate SC recovery from surfactant damage [27] . We found greater recovery and higher MAT for SP than NO and the creams.…”

“…Superficial wounds treated with semipermeable films have increased barrier recovery compared to wounds treated with complete occlusion or no occlusion [26,27] . Application of semipermeable films to infants !…”

Effect of Aqueous Cream BP on human stratum corneum in vivo

“…18 In skin research, SLS is a known enhancer of drug permeation across the skin, 4,12 has induced damage to the barrier to mimic the effects of skin disease, and has been used to elicit skin irritation in experimental models of irritant contact dermatitis. [4][5][6][7][8][9][10][11]19,20 In all of these examples, it is apparent that SLS is changing the effectiveness of the skin barrier, and various studies have shown that the application of SLS 1% w ⁄v solutions to normal human forearm skin for anywhere between 4 and 24 h provokes a sustained elevation of baseline TEWL (as seen in this study) in addition to clear structural changes in the SC. [20][21][22][23][24][25] With respect to the effect of SLS on SC structure, the increases in TEWL have been correlated with intercellular lipid disorganization 25 and perturbation of lamellar bodies in the stratum compactum.…”

“…SLS is an anionic, amphiphilic surfactant extensively used for its solubilizing, wetting, suspension, stabilization and emulsifying properties in consumer and industrial products ranging from food to pharmaceutical preparations 18 . In skin research, SLS is a known enhancer of drug permeation across the skin, 4,12 has induced damage to the barrier to mimic the effects of skin disease, and has been used to elicit skin irritation in experimental models of irritant contact dermatitis 4–11,19,20 …”

Evidence of increased skin irritation after wet work: impact of water exposure and occlusion

“…Only long-term experimental exposure has shown that occlusion via closed chambers (35) or via prolonged glove occlusion (6 hr/day for 14 days)(13) induces an elevation in TEWL, indicating a negative effect on skin barrier function. However, when pre-irritation of the skin of the hand or back (9,13,14,36,37) was followed by occlusion (37) or water immersion (9), differences in skin physiology were shown, mainly characterized by changes in TEWL (33), with decreased healing of SLS-damaged skin (15).…”