Effect of Aqueous Cream BP on human stratum corneum <i>in vivo</i>

Tsang, Manda; Guy, Richard H.

doi:10.1111/j.1365-2133.2010.09954.x

Cited by 74 publications

(46 citation statements)

References 23 publications

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“…In contrast to aqueous cream, the test emollient, after 28 days of treatment, improved skin barrier function (decreased TEWL) and SC integrity compared to an untreated control in volunteers with dry skin aged over 60 years. The negative effects of aqueous cream have been attributed to the use of SLS as an emulsifier [17,25]. SLS is a standard skin irritant, eliciting multiple negative effects on the skin including elevation of skin surface pH and reduction in skin barrier function (elevated TEWL) [26].…”

Section: Discussionmentioning

confidence: 99%

“…The response of participants with a history of AD (33%) was different to those without a history of AD; however, the size of the subgroups was not large enough to permit a proper subgroup analysis. Nevertheless, evidence already shows that individuals with a history of AD are more prone to skin barrier damage from topical products [15,17]. Neither treatment adversely affected lipid chain conformation determined by FTIR [23]; however, the control emollient was associated with significantly elevated skin surface pH and protease activity compared to the test emollient.…”

Section: Discussionmentioning

confidence: 99%

“…For example, some optimally designed emollients containing humectants ameliorate skin dryness and reduce the severity of skin inflammation [11,12,13]. In stark contrast, aqueous cream, containing the harsh anionic surfactant sodium lauryl sulphate (SLS) and no humectant, was found to damage the skin barrier [14,15,16,17], an effect linked to high rates of adverse reactions and exacerbation of AD symptoms [18]. In response to growing evidence and improvements in emollient formulation, a recent consensus statement by health care professionals highlighted the need to differentiate emollients based on their mechanism of action [19].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin

Danby

Brown

Higgs-Bayliss

et al. 2016

Skin Pharmacol Physiol

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Xerosis affects up to 75% of older people and develops as a result of a skin barrier defect. Emollients are widely used to treat xerosis; however, there is limited understanding of the differences between them and their effects on the skin barrier in older people. This study aimed to compare the effect of a commercially available emollient containing 5% urea, ceramide NP and lactate (test emollient) to an alternative emollient without these additives (control emollient) on the properties of the skin barrier in older people. Two cohorts of 21 volunteers aged >60 years with dry skin were recruited. The first applied the test emollient to one forearm and no treatment to the other for 28 days. The second compared the test emollient to the control emollient observing the same parameters. Effects on the skin barrier were determined by measuring skin barrier function, hydration, skin surface pH and by analysing Fourier transform infrared spectra before and after treatment. A third cohort of 6 young adults was recruited to investigate the effect of a single treatment with the test emollient on the molecular structure of the skin barrier at greater depths by employing the tape-stripping technique. The test emollient hydrated the skin to a significantly greater extent and for a longer period of time compared to the control emollient, an effect associated with a significant elevation of carboxylate groups (a marker of natural moisturizing factor content) within the stratum corneum. Furthermore, the test emollient imparted additional benefits to the structure and function of the skin barrier not exhibited by the control emollient. In conclusion, the test emollient addressed the pathological features of xerotic aged skin, supporting its use as first-line therapy for xerotic skin conditions in this population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin

Danby

Brown

Higgs-Bayliss

et al. 2016

Skin Pharmacol Physiol

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“…However, the picture would not be complete without mentioning his work on the skin barrier function including that of premature neonates [19,30,104,126,127] and the recent work on the effect of aqueous cream BP on human SC [128]. Other highly cited work includes that on plasma membrane poration by Mehier-Humbert et al [10], on micro-emulsions [8] and on sonophoresis [12,17].…”

Section: Other Contributionsmentioning

confidence: 99%

Richard Guy and His Collaborators: ‘Crackling' the Skin Code

Delgado‐Charro

2013

Skin Pharmacol Physiol

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This paper aims to summarize the contributions of Richard Guy and collaborators to the skin field. Major contributions have been areas such as the modelling of skin absorption, use of spectroscopic techniques (Fourier transform infrared spectroscopy, attenuated total reflectance Fourier transform infrared spectroscopy and impedance spectroscopy) to characterize the skin barrier and the effects of enhancing techniques on the membrane, dermatopharmacokinetics and assessment of topical bio-availability, iontophoresis and reverse iontophoresis, and use of imaging techniques to elucidate pathways of penetration and the skin disposition of nanoparticles. The field of topical and transdermal drug delivery has benefitted incalculably from the extensive work of Guy and his group: their findings about mechanisms of drug delivery and permeation enhancement, and the development of methodologies which are now accepted as gold standards by skin scientists.

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“…Aqueous cream was designed as a wash-off emollient soap substitute (containing 1% sodium lauryl sulfate, or SLS), not as a leave-on emollient, and the damaging effects it has on the skin barrier are an illustration of the hazards of using a topical product incorrectly . Aqueous cream even induced damage to the normal skin barrier by thinning the stratum corneum (SC) when applied twice per day for 4 weeks (Tsang and Guy 2010).…”

Section: Atopic Dermatitis and Impaired Barriermentioning

confidence: 99%