Seminal Plasma Creatine Kinase Activity in Fertility Studies

Buitrago, José Manuel González de; Miralles, José Manuel Pavía; Muńoz, M H; Meza, S; Alonso, Marco; Diez, Laurent

doi:10.3109/01485018008987006

Cited by 6 publications

(2 citation statements)

References 6 publications

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“…In a preliminary communication published in The Lancet back in 1963, Lehmann and Griffiths [ 23 ] suggested that extremely high concentrations of creatine kinase found in seminal fluid (385–14,000 IU) might be used in tracking azoospermia. This seminal article was followed by a handful of reports describing creatine kinase levels in fertility studies [ 24 , 25 , 26 ], with nearly all suggesting a relative value of the enzyme activity as an indicator of spermatogenesis. Arguably the first study about the seminal concentration of creatine and sperm viability was reported by Srivastava and co-workers [ 27 ].…”

Section: Biomarkers Of Creatine Metabolism and Sperm Qualitymentioning

confidence: 99%

Creatine as a Promising Component of Paternal Preconception Diet

2022

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Male fertility has been declining globally over the past several decades, advancing from a personal issue to a public health problem. Beyond any doubt, a reduction in fertility (often characterized by low sperm count or motility) can severely threaten reproductive health and lifecourse framework in a long-term fashion. Aside from uncovering the currently unknown etiology of modern-day male infertility, the scientific and medical community faces a double burden: finding an efficient biomarker of impaired fertility and exploring any intervention that can act to enhance fertility. A plethora of nutritional compounds have been recognized as possible modulators of semen quality, and specific dietary patterns and nutrients appear to be accompanied by a lower risk of male infertility. Creatine, a conditionally essential nutrient, has caught attention as a male fertility-promoting candidate due to its role in sperm energy metabolism. This mini-review describes the creatine-related bioenergetics of spermatozoa, explores a connection between creatine levels and sperm quality in men, and critically examines available evidence for interventional studies with creatine to affect sperm viability.

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Section: Biomarkers Of Creatine Metabolism and Sperm Qualitymentioning

confidence: 99%

Creatine as a Promising Component of Paternal Preconception Diet

2022

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“…At present, a large number of enzymes have been detected in human semen, with levels, in general, greater to those obtained in other body fluids. We have previously presented data which related the levels of various seminal enzymes with the spermiograms (Gonzalez Buitrago et al -1980;Gonzdez Buitrago et al -1981;Garcia Diez et al -1982). Leucine aminopeptidase (LAP; E.C.…”

Section: Introductionmentioning

confidence: 99%

Seminal Plasma Leucine Aminopeptidase in Male Fertility

Buitrago¹,

Navajo²,

Diez³

et al. 2009

Andrologia

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Summary: Leucine aminopeptidase (LAP) enzymatic activity has been measured in the seminal fluid of a group of 119 males undergoing fertility check‐up, and correlated with spermatic density. The results indicate that there exists a direct correlation between LAP activity in the seminal plasma and spermatic density. However, differences between the groups considered according to spermatic density are not significant. Seminal plasma mean Leucine aminopeptidase is 40 times higher than that found in blood plasma. Zusammenfassung: Die enzymatische Aktivität der Leucin‐Aminopeptidase (LAP) wurde im Spermaplasma bei einer Gruppe von 119 Männern, die sich einer Fertilitätsuntersuchung unterzogen, gemessen und in Beziehung zur Spermatozoendichte gesetzt. Die Ergebnisse zeigen, daß ein direkter Zusammenhang zwischen LAP‐Aktivität im Spermaplasma und der Spermatozoendichte besteht. Jedoch sind die Unterschiede zwischen den Gruppen, betrachtet nach der Spermatozoendichte, nicht signifikant. Der Durchschnittswert der LAP im Spermaplasma ist 40 mal höher als im Blutplasma.

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Enzymatic and electrolytic profiles of human semen

Gershbein

Thielen

1988

The Prostate

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Chemical parameters comprising urea and creatinine nitrogen, cations (Na+, K+, and Ca2+), chloride, phosphorus, protein, cholesterol and enzymes, aminotransferases, alkaline and prostatic acid phosphatases, gamma-glutamyltransferase, creatine kinase, and lactate dehydrogenase were ascertained for semen from groups A (vasectomized), B (oligospermic), and C (normospermic) men, 19 to 55 years of age. Of the parameters, the vasectomized group underwent definite depressions in potassium ion, alkaline phosphatase, aspartate aminotransferase, gamma-glutamyltransferase, and lactate dehydrogenase as compared with the normospermic group; the last three enzymes and, possibly, the urea-creatinine ratio were decreased for the oligospermic group vs. the normospermic men. In the comparison of groups A and B, only the decrements in alanine aminotransferase and lactate dehydrogenase were statistically significant. In corroboration of past reports, CK-BB comprised the main isoenzyme of semen creatine kinase.

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Seminal Plasma Creatine Kinase Activity in Fertility Studies

Cited by 6 publications

References 6 publications

Creatine as a Promising Component of Paternal Preconception Diet

Creatine as a Promising Component of Paternal Preconception Diet

Seminal Plasma Leucine Aminopeptidase in Male Fertility

Enzymatic and electrolytic profiles of human semen

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