Semicarbazide-sensitive amine oxidase in aortic smooth muscle cells mediates synthesis of a methylglyoxal-AGE: implications for vascular complications in diabetes

Mathys, Kenneth C.; Ponnampalam, Stephen N; Padival, Simi; Nagaraj, Ram H.

doi:10.1016/s0006-291x(02)02293-3

Cited by 40 publications

(36 citation statements)

References 48 publications

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“…Hyperglycemia result in higher accumulated amounts of AGEs in the blood vessels that induces proliferation of smooth muscle cell, thickening of intima (due to plaque formation and its sedimentation), and rigidity and stiffness of the vessels [16,17]. Foam cell formation is considered as a risk factor for atherosclerosis.…”

Section: Atherosclerosismentioning

confidence: 99%

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

et al. 2015

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Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid, yields irreversible heterogeneous compounds known as advanced glycation end products. Those products play a significant role in diabetic complications. In the present article we briefly discuss the contribution of advanced glycation end products to the pathogenesis of diabetic complications, such as atherosclerosis, diabetic retinopathy, nephropathy, neuropathy, and wound healing. Then we mention the various mechanisms by which polyphenols inhibit the formation of advanced glycation end products. Finally, recent supporting documents are presented to clarify the inhibitory effects of polyphenols on the formation of advanced glycation end products. Phytochemicals apply several antiglycation mechanisms, including glucose metabolism, amelioration of oxidative stress, scavenging of dicarbonyl species, and up/down-regulation of gene expression. To utilize polyphenols in order to remedy diabetic complications, we must explore, examine and clarify the action mechanisms of the components of polyphenols.

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Section: Atherosclerosismentioning

confidence: 99%

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

et al. 2015

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“…Although SSAO activity itself has been recognized for several decades, relatively little has been known about the physiological functions of these enzymes. In general, the end-products of the reaction at high concentrations are highly cytotoxic and implicated in playing a role in various processes resulting in cellular damage, like atherosclerosis and vascular complications in diabetes [1][2][3]. In addition, SSAO activity has been shown to be involved in glucose transport [4][5][6], adipocyte differentiation [7], and structural organization of vascular smooth muscle [8,9].…”

Section: Introductionmentioning

confidence: 99%

The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase

Kaitaniemi

Elovaara

Grön

et al. 2009

Cell. Mol. Life Sci.

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Semicarbazide-sensitive amine oxidases (SSAOs) catalyze oxidative deamination of primary amines, but the true physiological function of these enzymes is still poorly understood. Here, we have studied the functional and structural characteristics of a human cell-surface SSAO, AOC2, which is homologous to the better characterized family member, AOC3. The preferred in vitro substrates of AOC2 were found to be 2-phenylethylamine, tryptamine and p-tyramine instead of methylamine and benzylamine, the favored substrates of AOC3. Molecular modeling suggested structural differences between AOC2 and AOC3, which provide AOC2 with the capability to use the larger monoamines as substrates. Even though AOC2 mRNA was expressed in many tissues, the only tissues with detectable AOC2-like enzyme activity were found in the eye. Characterization of AOC2 will help in evaluating the contribution of this enzyme to the pathological processes attributed to the SSAO activity and in designing specific inhibitors for the individual members of the SSAO family.

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“…As such, it may contribute to the MAO activity registered in, for example, aortic SMCs (Jaakkola et al 1999). MAO activity in vascular SMC has been implicated as a potential source of advanced glycosylation end products (Mathys et al 2002). SMC specificity, a potential for pharmacological manipulation, and coupling to medically relevant processes motivate further studies of this protein.…”

Section: Smaomentioning

confidence: 99%

Prediction of Cell Type-Specific Gene Modules: Identification and Initial Characterization of a Core Set of Smooth Muscle-Specific Genes

Nelander¹,

Mostad²,

Lindahl³

2003

Genome Res.

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Genes that are expressed in the same subset of cells potentially constitute a module regulated by shared cis-regulatory elements and a distinct set of transcription factors. Identifying such units is an important entry point to the molecular study of cell differentiation. We developed a general method to classify cell type-specific genes from expressed sequence tag (EST) data, and we optimized it for identification of smooth muscle cell (SMC)-specific genes. Expression profiles were derived from the quantitative distribution of EST data in mouse, and genes were classified based on their profile similarity to known reference genes, in this case smooth muscle myosin heavy chain. A large majority (>90%) of known SMC-specific genes were identified, together with novel candidates. Extensive experimental validation confirmed SMC-specific expression of candidates, for example, lipoma preferred partner (LPP) and a novel SMC-specific putative monoamine oxidase, SMAO. Our method performed considerably better than other computational methods in an objective cross validation comparison. The total number of SMC-specific genes is estimated to be ∼50.

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Semicarbazide-sensitive amine oxidase in aortic smooth muscle cells mediates synthesis of a methylglyoxal-AGE: implications for vascular complications in diabetes

Cited by 40 publications

References 48 publications

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase

Prediction of Cell Type-Specific Gene Modules: Identification and Initial Characterization of a Core Set of Smooth Muscle-Specific Genes

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