Semibath Polymerization Approach for One-Pot Synthesis of Temperature- and Glucose-Responsive Core-Shell Nanogel Particles

Abstract

Herein, we report a simple and easy procedure for the synthesis of core-shell structures of glucose-sensitive 3-acrylamidophenylboronic acid (APBA) and temperature-responsive P(NIPAm-AAc) shell nanogel particles using MBA as a cross-linker via free radical polymerization. The synthesized particles were approximately 100 nm and were cross-linked to one another. The shell thickness of the nanogel particles was adjusted by increasing the concentrations of NIPAm through the semibath approach during the process of polymerization. The synthesized colloidal nanogel particle shows thermoresponsive behaviors. The dynamic light scattering technique also confirmed the change in the size of particles dispersed in an aqueous solution upon increase/decrease in temperatures, which is the result of its volume phase transition temperatures (VPTT). The size and morphology of the particles were characterized by TEM, FE-SEM, and AFM. The sensitivity of these nanogel particles to temperature and glucose suggests that they have the potential for applications related to the delivery of self-regulated insulin.

Biodegradable porous micro/nanoparticles with thermoresponsive gatekeepers for effective loading and precise delivery of active compounds at the body temperature

“…The sol–gel transition was observed upon temperature changes. The nanogels form a sol phase at room temperature or below T VPT , while at temperatures higher than T VPT, these become hydrophobic or a gel phase due to hydrogen bonding disruption, leading to a turbid solution 29 , 34 .…”

Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy

“…The results showed that the introduction of NIPAAm makes the composite material thermally sensitive, and the addition of AAPBA reduces the molecular weight of the copolymer, enhances the intermolecular aggregation of nanoparticles, and reduces the LCST of the composite material such that the copolymer reacts to glucose. Aslam et al 44 used MBA as a crosslinking agent to synthesize glucose-sensitive 3-acrylamidoboronic acid (APBA) and temperature-sensitive P(NIPAm-AAc) shell nanogel particles through free radical polymerization. The synthesized particles are approximately 100 nm in size and crosslinked with each other; the synthesized colloidal nanogel particles have thermal response characteristics.…”