Stimuli-responsive strategies: Role of various molecules/moieties facilitating the design of stimuli-responsive nanocarriers

Salve, Rajesh; Kumar, Pramod; Gajbhiye, Kavita R.; Babu, R. Jayachandra; Gajbhiye, Virendra

doi:10.1016/b978-0-12-824456-2.00013-8

Cited by 4 publications

(3 citation statements)

References 104 publications

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“…The selection of a stimulus will depend on the characteristic of the molecular component (sensitivity to a specific type of stimuli), its capability to promote a particular change on the anchored material, and the specific task application. [ 380 ] Some of the advantages of implanting molecular switches on materials/surfaces relies on i) high precision design at the molecular level, ii) low energy operando, iii) rapid response time, and iv) tunability and reversibility of the optoelectronic properties. However, it can also involve some drawbacks, such as i) limited operating conditions, ii) short‐term stability (durability), iii) costly large‐scale production (scalability), and iv) versatility for different applications.…”

Section: Stimuli‐responsive Molecules Triggered By Different External...mentioning

confidence: 99%

Rational Design of Stimuli‐Responsive Inorganic 2D Materials via Molecular Engineering: Toward Molecule‐Programmable Nanoelectronics

Muñoz

2023

Advanced Materials

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The ability of electronic devices to act as switches makes digital information processing possible. Succeeding graphene, emerging Inorganic 2D Materials (i2DMs) have been identified as alternative 2D Materials to harbor a variety of active molecular components to move the current silicon‐based semiconductor technology forward to a post‐Moore era based on molecule‐based information processing components. In this regard, i2DMs benefits not only for their prominent physiochemical properties (e.g., the existence of band gap, contrary to graphene), but also their high surface‐to‐volume ratio rich in reactive sites (functionalization capability). Nonetheless, since this field is still in an early stage, having knowledge of both i) the different strategies for molecularly functionalizing the current library of i2DMs, and ii) the different types of active molecular components is a sine qua non condition for a rational design of stimuli‐responsive i2DMs capable of performing logical binary operations at the molecular level. Consequently, this Review provides a comprehensive tutorial for covalently anchoring ad hoc molecular components —as active units triggered by different external inputs— onto pivotal i2DMs to assess their role in the expanding field of Molecule‐Programmable Nanoelectronics for electrically monitoring bistable molecular switches. Limitations, challenges, and future perspectives of this emerging field which crosses materials chemistry with computation are critically discussed.This article is protected by copyright. All rights reserved

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Section: Stimuli‐responsive Molecules Triggered By Different External...mentioning

confidence: 99%

Rational Design of Stimuli‐Responsive Inorganic 2D Materials via Molecular Engineering: Toward Molecule‐Programmable Nanoelectronics

Muñoz

2023

Advanced Materials

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“…Thus, the controlled-release mechanism and precise kinetic of stimuli-responsive NCs after accumulation in tumour tissue upon on-demand stimuli guarantee high-dose drug delivery and reduce undesired uptake by non-malignant cells. 62,73 Generally, the successful release mechanism of stimuli-responsive NCs and SMDCs relies on triggered cleavability within the tumour microenvironment (internal stimuli), such as pH, enzymatic acidity, glutathione, hypoxia, redox potential change via ROS, or external stimuli, such as UV-vis-NIR irradiation, electromagnetic or magnetic induction, ultrasound, temperature, photo induction, and mechanical factors. These elements facilitate the controlled degradation of drug transporters into individual units through the fracture of linkers and spacers, ensuring effective drug delivery (Fig.…”

Section: Introductionmentioning

confidence: 99%

Package delivered: folate receptor-mediated transporters in cancer therapy and diagnosis

Ahmadi,

Ritter,

von Woedtke

et al. 2024

Chem. Sci.

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“…[1] In this context, a bioactive molecule, referred to as the payload, undergoes temporary masking through protecting groups to address challenges such as low solubility or specificity. [2] To restore the biological activity of the payload, a specific trigger or stimulus initiates deprotection. Despite the efficacy of release mechanisms, certain conditions, such as steric hindrance or covalent bond stability, may render the release of payloads ineffective.…”

Section: Introductionmentioning

confidence: 99%

A Computational Perspective on the Reactivity of π‐spacers in Self‐Immolative Elimination Reactions

Padula

2024

Chemistry An Asian Journal

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The controlled release of chemicals, especially in drug delivery, is crucial, often employing “self–immolative” spacers to enhance reliability. These spacers separate the payload from the protecting group, ensuring a more controlled release. Over the years, design rules have been proposed to improve the elimination process’s reaction rate by modifying spacers with electron–donating groups or reducing their aromaticity. The spacer design is critical for determining the range of functional groups released during this process. This study explores various strategies from the literature aimed at improving release rates, focusing on the electronic nature of the spacer, its aromaticity, the electronic nature of its substituents, and the leaving groups involved in the elimination reaction. Through computational analysis, I investigate activation free energies by identifying transition states for model reactions. My calculations align qualitatively with experimental results, demonstrating the feasibility and reliability of computationally pre–screening model self–immolative eliminations. This approach allows proposing optimal combinations of spacer and leaving group for achieving the highest possible release rate.

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Stimuli-responsive strategies: Role of various molecules/moieties facilitating the design of stimuli-responsive nanocarriers

Cited by 4 publications

References 104 publications

Rational Design of Stimuli‐Responsive Inorganic 2D Materials via Molecular Engineering: Toward Molecule‐Programmable Nanoelectronics

Rational Design of Stimuli‐Responsive Inorganic 2D Materials via Molecular Engineering: Toward Molecule‐Programmable Nanoelectronics

Package delivered: folate receptor-mediated transporters in cancer therapy and diagnosis

A Computational Perspective on the Reactivity of π‐spacers in Self‐Immolative Elimination Reactions

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