Semen Quality and the Gene for Rose Comb in the Domestic Fowl

Crawford, R. D.; Smyth, J. Robert

doi:10.3382/ps.0431551

Cited by 9 publications

(1 citation statement)

References 20 publications

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“…In female chicken, the size of comb is correlated to fecundity; for instance, domestic layers with large combs produce more eggs, which is potentially regulated by hormones (Wright et al, 2012), whereas, in male chicken, the comb size is inversely correlated to sperm viability (Navara et al, 2012). The type of comb is associated with sperm quality; for example, roosters with rose combs carrying homozygous allele have defective sperm motility (Crawford and Smyth, 1964; Imsland et al, 2012). The color of comb is also linked with sperm viability; for instance, it was reported that males with redder combs have higher percent of active sperms (Navara et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Genomic Analysis Reveals Pleiotropic Alleles at EDN3 and BMP7 Involved in Chicken Comb Color and Egg Production

Dong

Zhang

et al. 2019

Front. Genet.

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Artificial selection is often associated with numerous changes in seemingly unrelated phenotypic traits. The genetic mechanisms of correlated phenotypes probably involve pleiotropy or linkage of genes related to such phenotypes. Dongxiang blue-shelled chicken, an indigenous chicken breed of China, has segregated significantly for the dermal hyperpigmentation phenotype. Two lines of the chicken have been divergently selected with respect to comb color for over 20 generations. The red comb line chicken produces significantly higher number of eggs than the dark comb line chicken. The objective of this study was to explore potential mechanisms involved in the relationship between comb color and egg production among chickens. Based on the genome-wide association study results, we identified a genomic region on chromosome 20 involving EDN3 and BMP7 , which is associated with hyperpigmentation of chicken comb. Further analyses by selection signatures in the two divergent lines revealed that several candidate genes, including EDN3 , BMP7 , BPIFB3 , and PCK1 , closely located on chromosome 20 are involved in the development of neural crest cell and reproductive system. The two genes EDN3 and BMP7 have known roles in regulating both ovarian function and melanogenesis, indicating the pleiotropic effect on hyperpigmentation and egg production in blue-shelled chickens. Association analysis for egg production confirmed the pleiotropic effect of selected loci identified by selection signatures. The study provides insights into phenotypic evolution due to genetic variation across the genome. The information might be useful in the current breeding efforts to develop improved breeds for egg production.

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Section: Introductionmentioning

confidence: 99%

Genomic Analysis Reveals Pleiotropic Alleles at EDN3 and BMP7 Involved in Chicken Comb Color and Egg Production

Dong

Zhang

et al. 2019

Front. Genet.

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Comparative study of some characteristics of the semen of RR (rose comb) or rr (single comb) cockerels

Petitjean¹,

Servouse²,

Malineau³

et al. 1981

Reprod. Nutr. Dévelop.

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Identification of a sperm cell attribute responsible for subfertility of roosters homozygous for the rose comb allele

McLean

Froman

1996

Biology of Reproduction

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Fertility, sperm metabolism, sperm filling of oviductal sperm storage tubules (SST), and sperm motility were compared in subfertile roosters homozygous for the rose comb allele (R/R) and fertile controls (r/r or R/r males). As expected, fertility of R/R males was less than that of controls (p < 0.0001). The metabolic rate of spermatozoa from R/R males was also lower than that of controls (p < 0.05). Likewise, filling of SST in vivo was lower (p < 0.0001) for spermatozoa from R/R males than for control spermatozoa. However, in vitro filling of SST was not different between genotypes (p > 0.05). Motility of spermatozoa from R/R males was less than that of controls (p < 0.001) as determined by an objective spectrophotometric assay. Previous researchers have concluded that subfertility associated with homozygosity for the rose comb allele is attributable to a sperm-specific phenomenon. However, the cellular mechanism(s) responsible for the subfertile status were not defined. In contrast to previous researchers, we have demonstrated that subfertility of R/R males is explicable in terms of reduced sperm transport through the hen's vagina; reduced sperm motility appears to be the major contributing factor.

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Semen Quality and the Gene for Rose Comb in the Domestic Fowl

Cited by 9 publications

References 20 publications

Genomic Analysis Reveals Pleiotropic Alleles at EDN3 and BMP7 Involved in Chicken Comb Color and Egg Production

Genomic Analysis Reveals Pleiotropic Alleles at EDN3 and BMP7 Involved in Chicken Comb Color and Egg Production

Comparative study of some characteristics of the semen of RR (rose comb) or rr (single comb) cockerels

Identification of a sperm cell attribute responsible for subfertility of roosters homozygous for the rose comb allele

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