SEM examination of the dorsal lingual papillae of pregnant rats

Yücel, Ferruh; Akdoğan, Ilgaz; Güven, Gül; Ortug, Gursel

doi:10.1016/s0940-9602(02)80116-9

Cited by 15 publications

(11 citation statements)

References 16 publications

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“…It was recently reported that taste receptor genes Tas1r1, Tas1r2, Tas1r3, and their associated G-protein genes were detected in the intra-ventricular epithelial cells of CP, probably allowing neurons to have proximal access to the contents of the CSF and to modulate their responses [28]. Previous evidence on the regulation of this pathway by the hormonal background showed that female rats experience changes in taste bud morphology during pregnancy [29]. Moreover the response of the parabrachial pons to bitter taste is increased in OVX rats comparing to controls [30].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Effects of Sex Hormone Background on the Rat Choroid Plexus Transcriptome by cDNA Microarrays

et al. 2013

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The choroid plexus (CP) are highly vascularized branched structures that protrude into the ventricles of the brain, and form a unique interface between the blood and the cerebrospinal fluid (CSF), the blood-CSF barrier, that are the main site of production and secretion of CSF. Sex hormones are widely recognized as neuroprotective agents against several neurodegenerative diseases, and the presence of sex hormones cognate receptors suggest that it may be a target for these hormones. In an effort to provide further insight into the neuroprotective mechanisms triggered by sex hormones we analyzed gene expression differences in the CP of female and male rats subjected to gonadectomy, using microarray technology. In gonadectomized female and male animals, 3045 genes were differentially expressed by 1.5-fold change, compared to sham controls. Analysis of the CP transcriptome showed that the top-five pathways significantly regulated by the sex hormone background are olfactory transduction, taste transduction, metabolism, steroid hormone biosynthesis and circadian rhythm pathways. These results represent the first overview of global expression changes in CP of female and male rats induced by gonadectomy and suggest that sex hormones are implicated in pathways with central roles in CP functions and CSF homeostasis.

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Section: Discussionmentioning

confidence: 99%

Analysis of the Effects of Sex Hormone Background on the Rat Choroid Plexus Transcriptome by cDNA Microarrays

et al. 2013

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“…A human study showed that women have more fungiform papillae and more taste buds than men (Bartoshuk et al 1994). A study in rats showed that changes in taste bud morphology occur during pregnancy (Yucel et al 2002). Electron microscopical scanning of the lingual papillae of pregnant rats showed differences in topographical configurations of these papillae as compared to those of control rats (Yucel et al 2002).…”

Section: Part Ii: Pregnancy and Taste Changesmentioning

confidence: 99%

“…A study in rats showed that changes in taste bud morphology occur during pregnancy (Yucel et al 2002). Electron microscopical scanning of the lingual papillae of pregnant rats showed differences in topographical configurations of these papillae as compared to those of control rats (Yucel et al 2002). Also in rat studies, at the level of the brainstem, some gender differences have been shown in the strength of the response to certain stimuli of the parabrachial pons (Di Lorenzo and Monroe 1989).…”

Section: Part Ii: Pregnancy and Taste Changesmentioning

confidence: 99%

A Brief Review on How Pregnancy and Sex Hormones Interfere with Taste and Food Intake

2009

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Many physiological and behavioral changes take place during pregnancy, including changes in taste and an increase in food intake. These changes are necessary to ensure growth and development of a healthy fetus. Both hyperphagia and taste changes during pregnancy may be induced by sex hormones estrogen and progesterone that are increased during pregnancy. Indeed, it has been shown that estrogen decreases food intake, while progesterone increases food intake. This is for instance apparent from the fact that food intake changes during the menstrual cycle with variation in sex hormones. This review will give a short overview of the effects of pregnancy and sex hormones on food intake and taste.

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“…However, Yucel et al (39) demonstrated that hormone alterations during pregnancy change the morphology of the lingual papillae, leading to an increase in gustatory sensibility. In scanning electron microscopy examination, these authors observed that the tongue of pregnant rats presented deeper sulcus around the circumvallate papilla, non-circular laminar configuration in the fungiform papillae, and disorganized direction of the filiform 204 J.C. JUNQUEIRA ET AL Table 2.…”

Section: Discussionmentioning

confidence: 99%

Experimental Candidosis and Recovery of Candida albicans from the Oral Cavity of Ovariectomized Rats

Junqueira

Colombo

Martins

et al. 2005

Microbiology and Immunology

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The aim of this study was to analyze the development of candidosis and the recovery of C. albicans from the oral cavity of ovariectomized and sham‐ovariectomized rats. One hundred and twenty‐four rats originally negative for Candida spp. in the oral cavity were divided into two groups: ovariectomized and sham‐ovariectomized. Fifty‐eight ovariectomized and the same quantity of sham‐ovariectomized rats were inoculated with C. albicans for the study of candidosis development and recovery of yeast. Four animals from each group were not inoculated with yeast suspension and were submitted to tongue dorsum morphologic analysis by optical and scanning electron microscopy. The development of candidosis in the tongue dorsum was observed by optical and scanning electron microscopy in the periods of 6 hr, 24 hr, 7 days and 15 days after the last inoculation. Recovery of C. albicans was performed by oral samples plating on Sabouraud agar after 1, 2, 5 and 7 days and progressively at each 15‐day interval until negative cultures for yeasts were obtained. The results were analyzed by Mann‐Whitney and Student's t tests. The tongue dorsum of sham‐ovariectomized and ovariectomized rats, not infected by Candida, presented normal aspect. Among the infected rats, the ovariectomized group showed less occurrence of candidosis lesions and lower recovery of C. albicans from the oral cavity in relation to the sham‐ovariectomized group. It could be concluded that candidosis was less frequent from the oral cavities of ovariectomized rats in relation to sham‐ovariectomized.

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SEM examination of the dorsal lingual papillae of pregnant rats

Cited by 15 publications

References 16 publications

Analysis of the Effects of Sex Hormone Background on the Rat Choroid Plexus Transcriptome by cDNA Microarrays

Analysis of the Effects of Sex Hormone Background on the Rat Choroid Plexus Transcriptome by cDNA Microarrays

A Brief Review on How Pregnancy and Sex Hormones Interfere with Taste and Food Intake

Experimental Candidosis and Recovery of Candida albicans from the Oral Cavity of Ovariectomized Rats

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