Self-healing PEG-poly(aspartic acid) hydrogel with rapid shape recovery and drug release

An, Heng; Zhu, Linmiao; Shen, Jiafu; Li, Wenjuan; Wang, Yong; Qin, Jianglei

doi:10.1016/j.colsurfb.2019.110601

Cited by 37 publications

(12 citation statements)

References 44 publications

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“…The preparation of the hydrogels was performed by following procedure. , First, the PEO DA with DP of 45, 90, and 135 and PNAP were dissolved into 10% solution, respectively, then the PNAP and PEO DA solutions were mixed together with 1/1 weight ratio and poured into corresponding molds to form hydrogels for various characterizations without stimulus. The PEO 45 DA, PEO 90 DA, and PEO 135 DA were used to regulate cross-linking density; the self-healing and mechanical properties of the hydrogel were investigated after 12 h of incubated at 25 °C.…”

Section: Experimental and Methodsmentioning

confidence: 99%

Hemostatic Self-Healing Hydrogel with Excellent Biocompatibility Composed of Polyphosphate-Conjugated Functional PNIPAM-Bearing Acylhydrazide

et al. 2021

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Biocompatible self-healing hydrogels present an effective application as drug-releasing vehicles for tissue engineering and wound repairing. At the same time, the effective hemostatic property of the hydrogels also improves the application property as wound dressing materials. In this research, the PNIPAM-bearing acylhydrazide P(NIPAM-co-AH) was synthesized and then hemostatic polyphosphate (PolyP) was imported to prepare polyphosphate-conjugated P(NIPAM-co-AH) (PNAP). Through the acylhydrazone connection of PNAP and aldehyde functional PEO (PEO DA), the self-healing hydrogel with a hemostatic property was fabricated with good flexibility and sealing effect. The resultant hydrogels kept excellent biocompatibility and showed controlled drug release behavior. More importantly, the hydrogel accelerated the coagulation rate in vitro and presented a strong hemostatic effect as the binder in the hemorrhage model in vivo, which endow the hemostatic hydrogel with a very useful drug delivery carrier for wound healing applications or first aid treatment of the wounded in critical situations.

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Section: Experimental and Methodsmentioning

confidence: 99%

Hemostatic Self-Healing Hydrogel with Excellent Biocompatibility Composed of Polyphosphate-Conjugated Functional PNIPAM-Bearing Acylhydrazide

et al. 2021

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“…Up to now, different hydrogels from both synthetic and natural hydrogels have been developed in various applications, such as tissue engineering, cell therapy, regenerative medicine, and stem cell and cancer research[ 31 , 32 ]. Synthetic hydrogels, such as poly(vinyl alcohol), polyacrylamide (PAM), and PEG, generally possess precise controllable performance and show high mechanical properties, but lack biological moieties[ 33 - 35 ]. On the other hand, natural hydrogels, such as chitosan, collagen, alginate, gelatin, and hyaluronic acid (HA), have received wide attention due to their bioactive properties.…”

Section: Soft Polymers Used For Creating Bolusmentioning

confidence: 99%

3D Printing Polymer-based Bolus Used for Radiotherapy

Lü

Song

Yao

et al. 2024

IJB

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Bolus is a kind of auxiliary device used in radiotherapy for the treatment of superficial lesions such as skin cancer. It is commonly used to increase skin dose and overcome the skin-sparing effect. Despite the availability of various commercial boluses, there is currently no bolus that can form full contact with irregular surface of patients’ skin, and incomplete contact would result in air gaps. The resulting air gaps can reduce the surface radiation dose, leading to a discrepancy between the delivered dose and planned dose. To avoid this limitation, the customized bolus processed by three-dimensional (3D) printing holds tremendous potential for making radiotherapy more efficient than ever before. This review mainly summarized the recent development of polymers used for processing bolus, 3D printing technologies suitable for polymers, and customization of 3D printing bolus. An ideal material for customizing bolus should not only have the feature of 3D printability for customization, but also possess radiotherapy adjuvant performance as well as other multiple compound properties, including tissue equivalence, biocompatibility, antibacterial activity, and antiphlogosis.

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“…[ 6 ] They also prepared hydrogels using hydrazide‐functionalized poly(aspartic acid), which was reacted with PEG‐dialdehyde. [ 80 ] All hydrogels self‐healed in 24 h and degraded in sodium carbonate solutions after 24 h (the former) or 7 d (the latter).…”

Section: Degradable Network With Self‐healing Properties Based On Dyn...mentioning

confidence: 99%

Degradable Self‐healable Networks for Use in Biomedical Applications

Grosjean

Gangolphe

Nottelet

2023

Adv Funct Materials

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Among biomaterials, 3D networks with capacities to absorb and retain large quantities of water (hydrogels) or withstand significant deformation and stress while recovering their initial structures at rest (elastomers) are largely used in biomedical applications. However, when damaged, they cannot recover their initial structures and properties. To overcome this limitation and satisfy the requirements of the biomedical field, self-healable hydrogels and elastomers designed using (bio)degradable or bioeliminable polymer chains have been developed and are becoming increasingly popular. This review presents the latest advances in the field of self-healing degradable/bioeliminable networks designed for use in health applications. The strategies used to develop such networks based on reversible covalent or physical cross-linking or their combination via dual/multi-cross-linking approaches are analyzed in detail. The key parameters of these hydrogels and elastomers, such as mechanical properties, repair and degradation times, and healing efficiencies, are critically considered in terms of their suitabilities in biomedical applications. Finally, their current and prospective uses as biomaterials in the fields of tissue engineering, drug/cell delivery, and medical devices are presented, followed by the remaining challenges faced to ensure the further success of degradable self-healable networks.

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Self-healing PEG-poly(aspartic acid) hydrogel with rapid shape recovery and drug release

Cited by 37 publications

References 44 publications

Hemostatic Self-Healing Hydrogel with Excellent Biocompatibility Composed of Polyphosphate-Conjugated Functional PNIPAM-Bearing Acylhydrazide

Hemostatic Self-Healing Hydrogel with Excellent Biocompatibility Composed of Polyphosphate-Conjugated Functional PNIPAM-Bearing Acylhydrazide

3D Printing Polymer-based Bolus Used for Radiotherapy

Degradable Self‐healable Networks for Use in Biomedical Applications

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