Hydrogels with inherent antibacterial ability are a focus in soft tissue repair. Herein, a series of antibacterial hydrogels were fabricated by quaternized N-[3-(dimethylamino)­propyl] methacrylamide (quaternized P­(DMAPMA-DMA-DAA)) bearing copolymers with dithiodipropionic acid dihydrazide (DTDPH) as cross-linker. The hydrogels presented efficient self-healing capability as well as a pH and redox-triggered gel–sol–gel transition property that is based on the dynamic acylhydrazone bond and disulfide linkage. Furthermore, the hydrogels showed good antibacterial activity, biocompatibility, degradability, and sustained release ability. More importantly, the in vivo experiments demonstrated that the hydrogels loaded with mouse epidermal growth factor (mEGF) significantly accelerated wound closure by preventing bacterial infection and promoting cutaneous regeneration in the wound model. The antibacterial hydrogels with self-healing behavior hold great potential in wound treatment.

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