‘Self-Cure’ in Nematode Infestations of Sheep

Stewart, D. F.

doi:10.1038/1761273b0

Cited by 72 publications

(14 citation statements)

References 3 publications

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“…Although the role of delayed hypersensi tivity in the development of resistance to Trichinella infection has been rather exten sively studied, that of immediate hypersensi tivity has received less attention despite the fact that there is some evidence for its in volvement [2,15,19].…”

Section: Introductionmentioning

confidence: 99%

Quantitation of Immediate and Delayed Hypersensitivity Responses in <i>Trichinella</i>-Infected Mice

Gabriel

Justus

1979

Int Arch Allergy Immunol

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The developmental relationships between active cutaneous or local anaphylaxis, delayed hypersensitivity and worm expulsion were quantitatively examined in Trichinella-infected mice. The onset of both types of hypersensitivities and increase in sensitivity to antigen following an initial infection correlated with the onset and rate of elimination of adult worms. Mice passively sensitized with serum containing both IgG₁ and IgE antibodies, but not IgG₁ alone, expelled their worms at a faster rate in comparison to the controls. On the basis of these findings it is suggested that local allergic reactions mediated by anaphylactic antibodies are involved in the development of resistance to Trichinella infection.

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Section: Introductionmentioning

confidence: 99%

Quantitation of Immediate and Delayed Hypersensitivity Responses in <i>Trichinella</i>-Infected Mice

Gabriel

Justus

1979

Int Arch Allergy Immunol

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“…This initial abdominal syndrome is usually benign in character and occurs during the 1st week. During the abdominal syndrome the antibody level against adults in maximal and may induce a "self-cure phenomenon" (STEWART 1955). A delayed abdominal syndrome has been observed in 35% of cases (OZERETKOVSKAYA 1968).…”

Section: Pathologymentioning

confidence: 99%

Chemotherapy of Gastrointestinal Nematodiasis in Man

Janssens¹

1985

Chemotherapy of Gastrointestinal Helminths

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“…The indirect mode of action of the immune response is exemplified in the selfcure phenomenon investigated by Stewart (1953Stewart ( , 1955. In addition, the immunological response of the host may affect the reproductive capacity or "fitness" of the parasite by (i) inhibition of development of the larval stages, (ii) suppression of the fecundity of adult worms, or (iii) termination of the infection (Donald, Dineen, Turner and Wagland, 1964), Consequently, during the course of evolution of the host-parasite relationship, the immunological response of the host may result in the selection of variants of the parasite which show reduced antigenic disparity with the host (Dineen, 1963b).…”

Section: Introdugtionmentioning

confidence: 99%

THE CELLULAR TRANSFER OF IMMUNITY TO TRICHOSTRONGYLUS COLUBRIFORMIS IN AN ISOGENIC STRAIN OF GUINEA‐PIG

Agland¹,

Dineen²

1965

Aust J Exp Biol Med

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Summary The mechanism of resistance of guinea‐pigs to infection with Trichostrongylus colubrifomis was investigated by transferring serum and mesenteric lymph nodes from resistant guinea‐pigs to susceptible guinea‐pigs of the same inbred strain. Inbred guinea‐pigs were used in these studies to avoid destruc tion of the transferred tissues by a homograft reaction. It was shown that the transfer of mesenteric lymph nodes prevented a primary infection from reaching patency in recipient guinea‐pigs, whereas a single injection of serum from resistant donors did not have any observable effect on the development of primary infection. It is concluded that the failure of susceptible guinea‐pigs to become infected with T. colubriformis was due to an immunological reaction in which cellular factors were more important than humoral antibodies. It is suggested that control of T. colubriformis and other helminth parasites with all stages confined to the alimentary tract may be mediated by a delayed type of hypersensitive reaction.

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‘Self-Cure’ in Nematode Infestations of Sheep

Cited by 72 publications

References 3 publications

Quantitation of Immediate and Delayed Hypersensitivity Responses in <i>Trichinella</i>-Infected Mice

Quantitation of Immediate and Delayed Hypersensitivity Responses in <i>Trichinella</i>-Infected Mice

Chemotherapy of Gastrointestinal Nematodiasis in Man

THE CELLULAR TRANSFER OF IMMUNITY TO TRICHOSTRONGYLUS COLUBRIFORMIS IN AN ISOGENIC STRAIN OF GUINEA‐PIG

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