Self-assembly of β-cyclodextrin and pluronic into hollow nanospheres in aqueous solution

Qin, Jie; Meng, Xianwei; Li, Bang‐Jing; Ha, Wei; Yu, Xiao‐Qi; Zhang, Sheng

doi:10.1016/j.jcis.2010.07.019

Cited by 31 publications

(36 citation statements)

References 48 publications

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“…F127ÀNH 2 ÀbCD aggregates were particles showed an obvious contrast between the central and outer part, which was a typical TEM image of hollow spheres and quite analogous to that of F127ÀOHÀb-CD as reported (Figure 1Ab). [19,[25][26][27][28][29] It should be noticed that diameter of the F127ÀNH 2 ÀbCD hollow particles in Figure 1Ab (around 100-200 nm) was little smaller than that from Dh (342 nm), which may resulted from the shrinkage of particles during the process of solvent evaporation in the sample preparation. After the introduction of PEI10K/DNA into the F127ÀNH 2 ÀbCD system, most aggregates showed particles similar to F127ÀNH 2 ÀbCD particles, but without bright cores (Figure 1Ac).…”

Section: Resultsmentioning

confidence: 95%

Self‐Assembly Pluronic and β‐Cyclodextrin to Hollow Nanospheres for Enhanced Gene Delivery

Fan

Zhang

Qin

et al. 2011

Macromol. Rapid Commun.

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This paper studies a kind of hollow nanospheres prepared by self-assembly β-cyclodextrins (β-CDs) and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (pluronic F127) for gene delivery. It was found that this kind of hollow nanospheres enable load PEI10K/DNA and the resulting F127NH2 βCD/(PEI10K/DNA) with 0.08 µg/well DNA display equal or higher gene delivery capability compared to PEI10K/DNA with 1 µg/well DNA in the absence or presence of serum. The cytotoxicity of the nanospheres was over 100 times lower than that of PEI10K.

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Section: Resultsmentioning

confidence: 95%

Self‐Assembly Pluronic and β‐Cyclodextrin to Hollow Nanospheres for Enhanced Gene Delivery

Fan

Zhang

Qin

et al. 2011

Macromol. Rapid Commun.

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“…[52][53][54][55][56][57] Fig. 13 shows the schematic illustration of the formation of alginate-gpoly(ethylene glycol) (Alg-g-PEG)-a-CD hollow spheres.…”

Section: Formation Of Nanoassemblies Via Interactions Between Cds Andmentioning

confidence: 99%

Nanoassemblies driven by cyclodextrin-based inclusion complexation

Kang

Guo

et al. 2014

Chem. Commun.

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Nanoscaled supramolecular systems have attracted significant attention because of their promising applications in many fields. This review focuses on recent advances in the construction of nanoassemblies driven by cyclodextrin (CD)-based inclusion complexation and their application in biomedical and biomimetic fields. As a result of the reversibility of the CD-based host-guest interactions, CD-based driving forces provide the opportunity to generate complex and sophisticated nanoassemblies with tunable properties.

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“…Our group lately fabricated a novel rod-coil complex, in which the rod-like blocks are formed by inclusion complexes of β-cyclodextrins (β-CDs) and poly (propylene oxide) (PPO) segments of the poly (ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers [6]. Because both β-CD and pluronics are water soluble and biocompatible, these hollow spheres are formed in aqueous solution and expected to have better biocompatibility compared with the existing self-assembled hollow spheres.…”

Section: Introductionmentioning

confidence: 99%