Nanoassemblies driven by cyclodextrin-based inclusion complexation

Kang, Yang; Guo, Kun; Li, Bang‐Jing; Zhang, Sheng

doi:10.1039/c4cc03131h

Cited by 76 publications

(61 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 Over the past few decades, numerous stimuli-sensitive micelles that respond to various stimuli, 4 such as pH, 5,6 temperature, 7,8 light, 9 redox species, 10 enzymes, 11 and ultrasound, 12,13 have been reported. In recent years, multisensitive micelles have become increasingly prevalent because they mimic the behavior of natural responsive materials and have high efficiency.…”

mentioning

confidence: 99%

Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers

Kang

Zhang

et al. 2015

ACS Macro Lett.

Self Cite

View full text Add to dashboard Cite

Two end-decorated homopolymers, methoxy polyethylene glycol-ferrocene (mPEG-Fc) and poly(N-isopropylacrylamide)-β-cyclodextrin (PNIPAM-β-CD), were further orthogonally self-assembled into stable micelles in aqueous solution by controlling the temperature of the solution via terminal host− guest interactions. Because of the H 2 O 2 cleavable CD/Fc connection and thermoresponsive PNIPAM, an H 2 O 2 and thermo dual-controlled drug release based on this system was also achieved. Interestingly, the cytotoxicity evaluation of mPEG-Fc/PNIPAM-β-CD indicated good biocompatibility. Compared with free doxorubicin, the doxorubicin-loaded supramolecular micelles exhibited equal cellular proliferation inhibition toward A549 cells. This supramolecular complex is thus anticipated to serve as a promising new type of alternative drug-delivery system.

show abstract

mentioning

confidence: 99%

Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers

Kang

Zhang

et al. 2015

ACS Macro Lett.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Various studies focused on some recent and encouraging advances in the application of cyclodextrin nanosystems for oral drug delivery. [135][136][137][138] Cyclodextrin in oral drug delivery Improvement of oral bioavailability of poorly aqueous soluble drugs is the most challenging step for the scientists in formulation and development of dosage forms. Cyclodextrins have unique structures with versatile physicochemical properties which lead to enhance the solubility, stability, and bioavailability of drugs in the gastrointestinal tract.…”

Section: Cyclodextrins and Nanotechnologymentioning

confidence: 99%

Untitled

Budhwar¹

2018

AJP

View full text Add to dashboard Cite

Inclusion complexes have various applications in different fields of drug delivery and pharmaceutical industry due to their ability of complexation with guest molecules and enhancement of the physicochemical properties of guest molecules. Cyclodextrins and their derivatives have the ability to encapsulate the bioactive compounds into its cavity and protect these from the environmental conditions, improve the solubility, bioavailability, and other properties also. The aim of this review is to highlight the advantages of cyclodextrins in the enhancement of physicochemical properties of drugs (such as solubility, stability, bioavailability, permeability, and others), different methods for production and various characterization techniques used for evaluation of complexes. Applications of cyclodextrin complexes in pharmaceutical and other fields are also explained here with examples. Thus cyclodextrins, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems accompanied with the delivery of different novel drugs through various delivery routes.

show abstract

“…The use of β-CD already has a long history in pharmaceuticals, pesticides, foodstuffs, etc. for the solubility, bioavailability, safety, stability and as a carrier of the guest molecules [7,8].…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Vitamin C into β‐Cyclodextrin for Advanced and Regulatory Release

Saha¹,

Roy²

2017

Vitamin C

View full text Add to dashboard Cite

Host-guest inclusion complex (IC) of vitamin C with β-cyclodextrin (β-CD) in aqueous medium has been explored by spectroscopic, physicochemical and calorimetric methods as stabilizer, carrier and regulatory releaser. Job plot has been drawn by UV-visible spectroscopy to confirm the 1:1 stoichiometry of the host-guest assembly. Stereo-chemical nature of the inclusion complex has been explained by two-dimensional (2D) NMR spectroscopy. Surface tension and conductivity studies further support the inclusion process. Association constants for the vitamin C-β-CD inclusion complex have been calculated by UV-visible spectroscopy using both Benesi-Hildebrand method and nonlinear programme, while the thermodynamic parameters have been estimated with the help of van't Hoff equation. Isothermal titration calorimetric study has been performed to determine the stoichiometry, association constant and thermodynamic parameters with high accuracy.

show abstract

Nanoassemblies driven by cyclodextrin-based inclusion complexation

Cited by 76 publications

References 70 publications

Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers

Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers

Untitled

Encapsulation of Vitamin C into β‐Cyclodextrin for Advanced and Regulatory Release

Contact Info

Product

Resources

About