Self‐Assembly of Rod–Coil Polyethylenimine–Poly(ethylene glycol)–α‐Cyclodextrin Inclusion Complexes into Hollow Spheres and Rod‐Like Particles

Cheng, Chuanfu; Han, Xiaobin; Dong, Zhenqiang; Liu, Yan; Li, Bang‐Jing; Zhang, Sheng

doi:10.1002/marc.201100514

Cited by 18 publications

(9 citation statements)

References 42 publications

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“…Therefore, the WSs@pH4 likely represent a type of wormlike micelles with hollow cavities (bright domains in Figure a–c). This was verified by the significantly smaller height (100–130 nm) than the width (1 μm) in the collapsed state (Figure S3d,h,l Supporting Information), which is generally attributed to a hollow structure as found for similar amphiphilic assemblies . Theoretically, the diameter of WSs@pH4 is much larger than the estimated chain length of extended PAH (95 nm), suggesting a hollow nature as well.…”

Section: Resultssupporting

confidence: 66%

Preparation of Novel Porphyrin Nanomaterials Based on the pH-Responsive Shape Evolution of Porphyrin Microspheres

et al. 2015

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The shapes and properties of self-assembled materials can be adjusted easily using environmental stimuli. Yet, the stimulus-triggered shape evolution of organic microspheres in aqueous solution has rarely been reported so far. Here, a novel type of poly(allylamine hydrochloride)-g-porphyrin microspheres (PAH-g-Por MPs) was prepared by a Schiff base reaction between 2-formyl-5,10,15,20-tetraphenylporphyrin (Por-CHO) and PAH doped in 3.5-μm CaCO3 microparticles, followed by template removal. The PAH-g-Por MPs had an average diameter of 2.5 μm and could be transformed into one-dimensional nanorods (NRs) and wormlike nanostructures (WSs) after being incubated for different times in pH 1-4 HCl solutions. The rate and degree of hydrolysis had a significant effect on the formation and morphologies of the nanorods. The NRs@pH1, NRs@pH2, and NRs@pH3 were all composed of the released Por-CHO and the unhydrolyzed PAH-g-Por because of the incomplete hydrolysis of the Schiff base. However, the WSs@pH4 were formed by a pure physical shape transformation, because they had the same composition as the PAH-g-Por MPs and the Schiff base bonds were not hydrolyzed. The self-assembled NRs and WSs exhibited good colloidal stability and could emit stable red fluorescence over a relatively long period of time.

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Section: Resultssupporting

confidence: 66%

Preparation of Novel Porphyrin Nanomaterials Based on the pH-Responsive Shape Evolution of Porphyrin Microspheres

et al. 2015

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“…Due to the propensity of the rigid blocks to pack in parallel, the rod‐coil complexes formed hollow particles. Varying the rigid block fraction was an effective way to control the morphology of the aggregates . In this study, PEI(10K)‐mPEG/α‐CD had a low rigid block fraction (rod:coil = 1:5) and self‐assembled to spheres, while PEI(2.5K)‐mPEG/α‐CD had a high rigid block fraction (rod:coil = 1:1) and self‐assembled to rod‐like particles.…”

Section: Resultsmentioning

confidence: 78%

“…Our recent research has demonstrated that rod‐coil complexes formed by CD and polymer chains could self‐assemble into hollow spheres or rod‐like tubes in aqueous solution by varying the rigid block length fraction . Earlier research focused on the methodology and control of morphology.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Rod‐Shaped Nanoparticles as Carriers for Gene Delivery

Fan

Zhang

Cheng

et al. 2014

Part & Part Syst Charact

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Fabrication of nonspherical particles for gene delivery remains a major challenge. In this study, novel rod-like nanoparticles are prepared for effi cient gene delivery by self-assembly of α-cyclodextrin (α-CD) and polyethyleniminemethoxy poly(ethylene glycol) (PEI-mPEG). The study reveals that the rod-like PEI-mPEG/α-CD particles can bind DNA effectively and the resulting PEImPEG/α-CD/DNA complexes show over four times higher gene delivery capability than their spherical counterparts and PEI(25K) due to more effi cient cellular uptake. Furthermore, the cytotoxicity of rod-like PEI-mPEG/α-CD is about fi ve times lower than that of the nanospheres, and 50 times lower than that of DNA/PEI(25K). These results indicate that shape is an important parameter for the design of gene delivery vectors. different design parameters of nonviral particles should be considered and optimized. There exists ample evidence that particle size [ 3 ] and surface chemistry [ 4 ] can dramatically infl uence gene transfection effi ciency. However, there is a striking lack of studies on the effect of particle shape on the gene delivery behavior.Recently, the importance of the shape of carriers in various biological processes has been realized. Emerging studies show that important biological processes such as biodistribution, cellular internalization, and toxicity exhibit strong dependence on shape. [ 5 ] The majority of the evidence available suggests that rod-like nanoparticles are more favorable for drug delivery applications. [ 6 ] But up to now, most nonviral gene vectors are spherical particles. There are only few reports on the gene delivery behavior of nonspherical nanoparticles, except needle-like histidine-lysine polymers, [ 7 ] inorganic nanotubes, [ 8 ] and some star-shaped polymeric vectors, [ 9 ] although actually a number of viruses are nonspherical in nature.The most prominent approach for fabricating rod-like particles has been self-assembly of amphiphilic copolymers. [ 10 ] However, preparing biocompatible rod-like particles with good DNAbinding capability via self-assembly and retention of shape in physiological conditions still remains a challenge. Most rod-like polymeric particles lack the desirable degradable components and only serve as a model system. To date, rare rod-like assemblies show potential for DNA binding, while good DNA-binding ability is necessary for a good gene delivery vector. [ 11 ] Our recent research has demonstrated that rod-coil complexes formed by CD and polymer chains could self-assemble into hollow spheres or rod-like tubes in aqueous solution by varying the rigid block length fraction. [ 12 ] Earlier research focused on the methodology and control of morphology. In this study, the work is extended to binding DNA using the self-assembly aggregates with different shapes and comparing their gene delivery capability. It was found that the particles prepared by α-cyclodextrin (α-CD) and polyethyleniminemethoxy poly(ethylene glycol) (PEI-mPEG) showed good DNA-binding ability, low cytotoxicity, an...

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“…Inspired from nature, some peptides (Block et al, 2005;Scanlon and Aggeli, 2013;Toksöz and Guler, 2009), amphiphilic molecules (Dalhaimer et al, 2004;Israelachvili et al, 1976;Kim et al, 2005), and dendritic molecules (Gillies and Fréchet, 2005;Ihre et al, 2002) have been shown to auto-assemble and to produce non spherical objects. For example a very interesting study by Cheng et al showed the possibility to self assemble rod-coil polyethylenimine-poly(ethylene glycol)-␣-cyclodextrin inclusion complexes into hollow spheres and rod-like particles (Cheng et al, 2011). Alternatively, polypeptides copolymers are known to self-associate and form various aggregate structures (Cai et al, 2011), ranging from spheres to worms and very elongated fibers and other structures.…”

Section: Introductionmentioning

confidence: 98%

Molecular weight controls the elongation of oblate-shaped degradable poly(γ-benzyl-l-glutamate)nanoparticles

Cauchois

Segura‐Sánchez

Ponchel

2013

International Journal of Pharmaceutics

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Self‐Assembly of Rod–Coil Polyethylenimine–Poly(ethylene glycol)–α‐Cyclodextrin Inclusion Complexes into Hollow Spheres and Rod‐Like Particles

Cited by 18 publications

References 42 publications

Preparation of Novel Porphyrin Nanomaterials Based on the pH-Responsive Shape Evolution of Porphyrin Microspheres

Preparation of Novel Porphyrin Nanomaterials Based on the pH-Responsive Shape Evolution of Porphyrin Microspheres

Evaluation of Rod‐Shaped Nanoparticles as Carriers for Gene Delivery

Molecular weight controls the elongation of oblate-shaped degradable poly(γ-benzyl-l-glutamate)nanoparticles

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