Molecular weight controls the elongation of oblate-shaped degradable poly(γ-benzyl-l-glutamate)nanoparticles

Cauchois, Olivier; Segura‐Sánchez, Freimar; Ponchel, Gilles

doi:10.1016/j.ijpharm.2013.04.074

Cited by 19 publications

(15 citation statements)

References 43 publications

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“…Yellow (and their corresponding bars) represents our and commonly used stabilizers, while red (and their corresponding bars) is denoted as commonly reported materials in synthesizing biodegradable and/or nonspherical nanoparticles for drug delivery and targeting. Abbreviations and further details of referred material–nanoparticles: SDS (sodium dodecyl sulfate), (2) Docusate‐Na, (3) Triton X‐100, (4) Na‐Cholate & ‐Deoxycholate, (5) PVP (poly(vinylpyrrolidone)), (6) PEG (poly(ethylene glycol)) 6000, (7) Dextran, (8) Poloxamer 188, (9) HSA (human serum albumin), (10) Chitosan, (11) Cyanoacrylate, (12) PS‐COOH (carboxylated poly(styrene)), (13) PS (poly(styrene)), (14) PDMS (poy(dimethylsiloxane)), (15) PMMA (poly(methyl methacrylate)), (16) PHEA (poly(hydroxyethyl acrylate)), (17) PHEMA (poly(hydroxyethyl methacrylate)), (18) PEGDA (poly(ethylene glycol) diacrylate)‐PHEMA (poly(hydroxyethyl methacrylate)), (19) CEA (2‐carboxyethyl acrylate), (20) PBLG (poly(γ‐benzyl l ‐glutamate)), (21) Triglyceride (cocoa butter), (22) P4VP (poly(4‐vinyl pyridine)), (23) Au (gold), and (24) SWCNT (single‐walled carbon nanotubes) …”

Section: Resultsmentioning

confidence: 99%

“…Second Instance: Unsuccessful Stretching at the Temperature Far Above Bulk T g Using Nanoparticles composed of High Young's Modulus, but Low T g Material : Cauchois reported his failure to stretch spherical poly(γ‐benzyl‐ l ‐glutamate) (PBLG) nanoparticles using film‐stretching method. PBLG, a rigid liquid crystalline material, has an unique (helical) internal structure, thus may exhibit either spherical or elongated particles, depending on its variants . It has rather high hydrophobicity (in‐between PLA‐COOH & PLGA 75/25‐COOH; Figure e), bulk Young's modulus 34 GPa, and T g ≈ 19 °C .…”

Section: Discussionmentioning

confidence: 99%

“…It has rather high hydrophobicity (in‐between PLA‐COOH & PLGA 75/25‐COOH; Figure e), bulk Young's modulus 34 GPa, and T g ≈ 19 °C . He found out that even the stretching process was performed at the temperature (i.e., 150°) far above the bulk T g , spherical PBLG nanoparticles were unsuccessful to be deformed into the elongated ones . The hydrogen bond, which should take an account as the main driving force in transforming stretched particles, seems work limitedly for soft material (<10 GPa), such as PS and PMMA .…”

Section: Discussionmentioning

confidence: 99%

“…Third, for nanoparticles having its own definite internal structure, large interfacial tension because of high hydrophobicity or very low Young's modulus could be simply overcome. As a consequence, they may generate superior shape stability or even, nonspherical nanoparticles spontaneously from the spheres over time …”

Section: Discussionmentioning

confidence: 99%

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Nonspherical Nanoparticle Shape Stability Is Affected by Complex Manufacturing Aspects: Its Implications for Drug Delivery and Targeting

Haryadi

Hafner

Amin

et al. 2019

Adv Healthcare Materials

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The shape of nanoparticles is known recently as an important design parameter influencing considerably the fate of nanoparticles with and in biological systems. Several manufacturing techniques to generate nonspherical nanoparticles as well as studies on in vitro and in vivo effects thereof have been described. However, nonspherical nanoparticle shape stability in physiological‐related conditions and the impact of formulation parameters on nonspherical nanoparticle resistance still need to be investigated. To address these issues, different nanoparticle fabrication methods using biodegradable polymers are explored to produce nonspherical nanoparticles via the prevailing film‐stretching method. In addition, systematic comparisons to other nanoparticle systems prepared by different manufacturing techniques and less biodegradable materials (but still commonly utilized for drug delivery and targeting) are conducted. The study evinces that the strong interplay from multiple nanoparticle properties (i.e., internal structure, Young's modulus, surface roughness, liquefaction temperature [glass transition (Tg) or melting (Tm)], porosity, and surface hydrophobicity) is present. It is not possible to predict the nonsphericity longevity by merely one or two factor(s). The most influential features in preserving the nonsphericity of nanoparticles are existence of internal structure and low surface hydrophobicity (i.e., surface‐free energy (SFE) > ≈55 mN m−1, material–water interfacial tension <6 mN m−1), especially if the nanoparticles are soft (<1 GPa), rough (Rrms > 10 nm), porous (>1 m2 g−1), and in possession of low bulk liquefaction temperature (<100 °C). Interestingly, low surface hydrophobicity of nanoparticles can be obtained indirectly by the significant presence of residual stabilizers. Therefore, it is strongly suggested that nonsphericity of particle systems is highly dependent on surface chemistry but cannot be appraised separately from other factors. These results and reviews allot valuable guidelines for the design and manufacturing of nonspherical nanoparticles having adequate shape stability, thereby appropriate with their usage purposes. Furthermore, they can assist in understanding and explaining the possible mechanisms of nonspherical nanoparticles effectivity loss and distinctive material behavior at the nanoscale.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Nonspherical Nanoparticle Shape Stability Is Affected by Complex Manufacturing Aspects: Its Implications for Drug Delivery and Targeting

Haryadi

Hafner

Amin

et al. 2019

Adv Healthcare Materials

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show abstract

“…Although usually smaller than asbestos fibers, there are concerns that they may cause similar adverse health effects upon inhalation. Nanoparticles may be given additional shapes like oblate spheroids [13]. This is a shape that also may describe wood chips and microparticles for drug delivery [14].…”

Section: Introductionmentioning

confidence: 99%

Modeling Transport and Deposition Efficiency of Oblate and Prolate Nano- and Micro-particles in a Virtual Model of the Human Airway

Holmstedt

Åkerstedt

Lundström

et al. 2016

Journal of Fluids Engineering

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A model for the motion and deposition of oblate and prolate spheroids in the nano-and microscale was developed. The aim was to mimic the environment of the human lung, but the model is general and can be applied for different flows and geometries for small nonspherical particle Stokes and Reynolds numbers. A study of the motion and orientation of a single oblate and prolate particle has been done yielding that Brownian motion disturbs the Jeffery orbits for small particles. Prolate microparticles still display distinguishable orbits while oblate particles of the same size do not. A statistical study was done comparing the deposition efficiencies of oblate and prolate spheroids of different size and aspect ratio observing that smaller particles have higher deposition rate for lower aspect ratio while larger particles have higher deposition rates for large aspect ratio.

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Polymer Nanoparticles for In Vivo Applications: Progress on Preparation Methods and Future Challenges

Vauthier

2016

Polymer Nanoparticles for Nanomedicines

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Molecular weight controls the elongation of oblate-shaped degradable poly(γ-benzyl-l-glutamate)nanoparticles

Cited by 19 publications

References 43 publications

Nonspherical Nanoparticle Shape Stability Is Affected by Complex Manufacturing Aspects: Its Implications for Drug Delivery and Targeting

Nonspherical Nanoparticle Shape Stability Is Affected by Complex Manufacturing Aspects: Its Implications for Drug Delivery and Targeting

Modeling Transport and Deposition Efficiency of Oblate and Prolate Nano- and Micro-particles in a Virtual Model of the Human Airway

Polymer Nanoparticles for In Vivo Applications: Progress on Preparation Methods and Future Challenges

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