Polymer Nanoparticles for In Vivo Applications: Progress on Preparation Methods and Future Challenges

Vauthier, Christine

doi:10.1007/978-3-319-41421-8_1

Cited by 10 publications

(9 citation statements)

References 72 publications

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“…The obtained spherical nanomaterials are generally small and have a good monodispersity [27]. The success of the method led to be widely used in the field of pharmaceutical science [28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of polyaniline (PANI) and functionalized polyaniline (F-PANI) nanoparticles with controlled size by solvent displacement method. Application in fluorescence detection and bacteria killing by photothermal effect

et al. 2018

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Polyaniline nanoparticles (PANI-NPs) were easily obtained applying the solvent displacement method by using N-methylpyrrolidone (NMP) as good solvent and water as poor solvent. Different polymers such as polyvinylpyrrolidone (PVP), chondroitin sulfate (ChS), polyvinyl alcohol (PVA), and polyacrylic acid (PAA) were used as stabilizers. Dynamic light scattering and scanning electron microscopy corroborated the size and morphology of the formed NPs. It was demonstrated that the size of nanoparticles could be controlled by setting the concentration of PANI in NMP, the NMP to water ratio, and the stabilizer's nature. The functionalization and fluorescence of NPs were checked by spectroscopic techniques. Since polyaniline show only weak intrinsic luminescence, fluorescent groups were linked to the polyaniline chains prior to the nanoparticle formation using a linker. Polyaniline chains were functionalized by nucleophilic addition of cysteamine trough the thiol group thereby incorporating pendant primary aliphatic amine groups to the polyaniline backbone. Then, dansyl chloride (DNS-Cl), which could act as an extrinsic chromophore, was conjugated to the amine pendant groups. Later, the functionalized polyaniline was used to produce nanoparticles by solvent displacement. The optical and functional properties of fluorescent nanoparticles (F-PANI-NPs) were determined. F-PANI-NPs in the conductive state (pH < 4) are able to absorb near infrared radiation (NIR) creating a photothermal effect in an aqueous medium. Thus, multifunctional nanoparticles are obtained. The application of NIR on a F-PANI-NPs dispersion in contact with Pseudomonas aeruginosa causes bacterial death. Therefore, the F-PANI-NPs could be tracked and applied to inhibit different diseases caused by pathogenic microorganisms and resistant to antibiotics as well as a new disinfection method to surgical materials.

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Section: Introductionmentioning

confidence: 99%

Synthesis of polyaniline (PANI) and functionalized polyaniline (F-PANI) nanoparticles with controlled size by solvent displacement method. Application in fluorescence detection and bacteria killing by photothermal effect

et al. 2018

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“…Considering the generally poor drug loading contents of any polyester-based colloidal carrier system, designing and optimizing drug delivery systems with high payload−host polymer ratios is an emerging problem. 8,12,16,17,20 Typically, a bioactive payload includes less than 5% of the carrier system by mass. The major issues may include low compatibility between the drug and polymer matrix (i), high crystallinity of the polymer or polymer blend, leading to limited space for drug molecules (ii), inappropriate location of the payload within the nanocarrier (iii), and a suboptimal physical state of the polymer matrix, leading to premature leakage of the drug (iv).…”

Section: Introductionmentioning

confidence: 99%

Effect of Temperature and Composition on the Loading of Curcumin into PLGA/PLLA Core–Shell Nanoparticles Stabilized by Hydrophobically Functionalized Polyelectrolytes

Lamch,

Szklarz

2024

Ind. Eng. Chem. Res.

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Our research comprised use of a vessel-type batch process of curcumin (CUR) core–shell entrapment, followed by an analysis of the thermal and dielectric behavior of polymer matrices, supported by theoretical calculations of the solubilities of particular polyester-type building blocks: poly(l-lactide) (PLLA) and poly(lactide-co-glycolide) (PLGA). Our investigation enabled us to design and optimize a fully scalable process characterized by very high (approximately 1 order of magnitude greater than previous systems) bioactive payload loading content. The optimal temperature and composition of the core material for curcumin entrapment was calculated using HSPiP software and confirmed by microscopic observation of polymers blended with curcumin, as well as by dielectric measurements and dynamic scanning calorimetry. Optimization studies showed that the most uniform core–shell nanocarriers, characterized by excellent drug loading, were obtained for the hydrophobically functionalized polyelectrolyte (HF-PE) with ester linking groups utilizing a process temperature of 85 °C, followed by rapid cooling to room temperature.

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“…Algunos autores han empleado THF (Tetrahidrofurano) [61,62,63]. En la fase acuosa comúnmente se utiliza sólo agua des-ionizada, aunque algunos excipientes como surfactantes hidrofilícos también se pueden añadir para que se agreguen las partículas [64] Figura 4.22: Esquema del proceso de preparación de las nanopartículas compuestas: Nanoprecipitación.…”

Section: Síntesis De Nanopartículas Compuestas (Npcs) 421 Nanoprecipi...unclassified

“…Lo cierto es, que en un diseño experimental como este, se cuentan con diferentes factores que pueden intervenir en el resultado final de tamaño de partículas. Existe en la literautra [64] resultados de diferentes trabajos que se pueden consultar; sin embargo, en estos se presentan diferencias que no son claras para aplicar en el estudio de nuestro sistema.…”

Section: Síntesis De Npcsunclassified

Efecto de las interacciones magnéticas en la disipación de calor de nanopartículas compuestas PCL/magnetita

Hernández Guzmán

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Polymer Nanoparticles for In Vivo Applications: Progress on Preparation Methods and Future Challenges

Cited by 10 publications

References 72 publications

Synthesis of polyaniline (PANI) and functionalized polyaniline (F-PANI) nanoparticles with controlled size by solvent displacement method. Application in fluorescence detection and bacteria killing by photothermal effect

Synthesis of polyaniline (PANI) and functionalized polyaniline (F-PANI) nanoparticles with controlled size by solvent displacement method. Application in fluorescence detection and bacteria killing by photothermal effect

Effect of Temperature and Composition on the Loading of Curcumin into PLGA/PLLA Core–Shell Nanoparticles Stabilized by Hydrophobically Functionalized Polyelectrolytes

Efecto de las interacciones magnéticas en la disipación de calor de nanopartículas compuestas PCL/magnetita

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