Effect of Temperature and Composition on the Loading of Curcumin into PLGA/PLLA Core–Shell Nanoparticles Stabilized by Hydrophobically Functionalized Polyelectrolytes
Łukasz Lamch,
Przemysław Szklarz
Abstract:Our research comprised use of a vessel-type batch process
of curcumin
(CUR) core–shell entrapment, followed by an analysis of the
thermal and dielectric behavior of polymer matrices, supported by
theoretical calculations of the solubilities of particular polyester-type
building blocks: poly(l-lactide) (PLLA) and poly(lactide-co-glycolide) (PLGA). Our investigation enabled us to design
and optimize a fully scalable process characterized by very high (approximately
1 order of magnitude greater than previous syst… Show more
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