Self-assembling peptides as immunomodulatory biomaterials

Hernández, Andrea; Hartgerink, Jeffrey D.; Young, Simon

doi:10.3389/fbioe.2023.1139782

Cited by 11 publications

(3 citation statements)

References 137 publications

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“…Self-assembling peptides (SAPs) are designer biomaterials readily available from naturally occurring amino acids that instinctively form cross-linked nanofibers, and are transformed into nanoscale hydrogels. 77,78 Liu et al . 37 reported the hepatocyte growth factor (HGF) and the TNF-α neutralizing antibody (anti-TNF-α) co-delivered using an injectable, self-assembling peptide/heparin (SAP/Hep) hydrogel (Fig.…”

Section: Drug Delivery Strategies For Renal Antifibrosismentioning

confidence: 99%

Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment

Huang,

Lu,

Chen

et al. 2024

J. Mater. Chem. B

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Section: Drug Delivery Strategies For Renal Antifibrosismentioning

confidence: 99%

Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment

Huang,

Lu,

Chen

et al. 2024

J. Mater. Chem. B

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“…Gelain and co-workers reported an in vivo study of biomimetic electrospun SAP micro-channels suitable to support NSC transplant in spinal cord injury [121]. Important results in the field of SAPs as biomaterials are emerging for cancer therapy [122,123], as immunomodulatory agents [124], and against antibiotic resistance [125], as well as for tissue regeneration, drug delivery [126], sensing [127,128], 3D printing [129], and nanomedicine [130][131][132]. protofilaments of microtubule assemble playing fundamental roles in eukaryotic cells [134,135].…”

Section: Self-assembling Peptidesmentioning

confidence: 99%

Recent Advances in the Development of Biomimetic Materials

Ciulla,

Massironi,

Sugni

et al. 2023

Gels

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In this review, we focused on recent efforts in the design and development of materials with biomimetic properties. Innovative methods promise to emulate cell microenvironments and tissue functions, but many aspects regarding cellular communication, motility, and responsiveness remain to be explained. We photographed the state-of-the-art advancements in biomimetics, and discussed the complexity of a “bottom-up” artificial construction of living systems, with particular highlights on hydrogels, collagen-based composites, surface modifications, and three-dimensional (3D) bioprinting applications. Fast-paced 3D printing and artificial intelligence, nevertheless, collide with reality: How difficult can it be to build reproducible biomimetic materials at a real scale in line with the complexity of living systems? Nowadays, science is in urgent need of bioengineering technologies for the practical use of bioinspired and biomimetics for medicine and clinics.

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“…They may possess hydrophilic or hydrophobic properties depending on the sequence of the amino acids that they are made of. For example, hydroxyl-containing amino acids make them more water-soluble [175,176]. Self-assembled scaffolds are characterized by soft and deformable structures due to the internal noncovalent forces that link their monomers, and as a result can take the shape of the damaged tissue when injected into damaged tissues or organs [177,178].…”

Section: Self-assembling Peptidesmentioning

confidence: 99%

Biomaterials in Traumatic Brain Injury: Challenges and Perspectives

Aqel,

Al-Thani,

Haider

et al. 2023

Preprint

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Traumatic brain injury (TBI) is among the leading causes of mortality and long-term impairment globally. TBI has a dynamic pathology encompassing a variety of metabolic and molecular events that occur in two phases, primary and secondary. An external forceful blow to the brain initiates the primary phase, which is followed by a secondary phase that involves the release of calcium ions (Ca2+) and the initiation of a cascade of inflammatory processes, including mitochondrial dysfunction, rise in oxidative stress, activation of glial cells, and damage to the blood-brain barrier (BBB), resulting in paracellular leakage. There is currently no FDA-approved drug for TBI, but existing approaches rely on delivering small and macromolecular treatments, which are severely constrained by the BBB, poor retention, off-target toxicity, and complex pathology of TBI. Therefore, there is a demand for innovative and alternative therapeutics with effective delivery tactics for diagnosis and treatment of TBI. Tissue engineering and use of biomaterials is one such alternative approach. With this approach, neuronal stem cell therapy is combined with synthetically generated tissue materials such as hydrogels, self-assembling peptides, and electrospun nanofibers, which may induce neurite outgrowth, differentiation of human neural stem cells, and nerve gap bridging in TBI. This review examines tissue engineering and the use of biomaterials as potential treatments for TBI, including their synthesis, mechanisms of action, and limitations. The review also discusses challenges facing tissue engineering and biomaterial technology including survival rate of transplanted stem cells and the development of biodegradable, biocompatible, and mechanically flexible biomaterials. A better understanding of the mechanisms and drawbacks of these novel therapeutic approaches will help guide the design of future TBI therapies.

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Self-assembling peptides as immunomodulatory biomaterials

Cited by 11 publications

References 137 publications

Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment

Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment

Recent Advances in the Development of Biomimetic Materials

Biomaterials in Traumatic Brain Injury: Challenges and Perspectives

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