Recent Advances in the Development of Biomimetic Materials

Ciulla, Maria G.; Massironi, Alessio; Sugni, Michela; Ensign, Matthew A.; Marzorati, Stefania; Forouharshad, Mahdi

doi:10.3390/gels9100833

Cited by 6 publications

(3 citation statements)

References 235 publications

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“…Hydrogel scaffolds can be crafted using both natural and synthetic polymers. Biomimetic materials, especially structural proteins like elastin and collagen, exhibit mechanical properties akin to those found in native tissues [24]. Conversely, synthetic materials showcase diverse chemical properties and molecular structures [25].…”

Section: Hydrogel: Basic Architecturementioning

confidence: 99%

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Rana,

De la Hoz Siegler

2024

Gels

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Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, and structural similarity to the extracellular matrix. Recent chemical advancements have bolstered their versatility, facilitating the integration of the molecules guiding cellular activities and enabling their controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity and network imperfections, which adversely affect their mechanical properties, diffusion rates, and biological activity. In response to these challenges, hybrid hydrogels have emerged, aiming to enhance their strength, drug release efficiency, and therapeutic effectiveness. These hybrid hydrogels, featuring improved formulations, are tailored for controlled drug release and tissue regeneration across both soft and hard tissues. The scientific community has increasingly recognized the versatile characteristics of hybrid hydrogels, particularly in the biomedical sector. This comprehensive review delves into recent advancements in hybrid hydrogel systems, covering the diverse types, modification strategies, and the integration of nano/microstructures. The discussion includes innovative fabrication techniques such as click reactions, 3D printing, and photopatterning alongside the elucidation of the release mechanisms of bioactive molecules. By addressing challenges, the review underscores diverse biomedical applications and envisages a promising future for hybrid hydrogels across various domains in the biomedical field.

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Section: Hydrogel: Basic Architecturementioning

confidence: 99%

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Rana,

De la Hoz Siegler

2024

Gels

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“…Recent advancements in biomimetic prosthetics have been facilitated by the convergence of various scientific disciplines [8][9][10]. Materials science has played a pivotal role in enabling the development of advanced materials that closely mimic the properties of biological tissues, thereby enhancing the comfort and functionality of prosthetic limbs [11].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Biomimetics for the Development of Bio-Inspired Prosthetic Limbs

Varaganti,

Seo

2024

Biomimetics

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Recent advancements in biomimetics have spurred significant innovations in prosthetic limb development by leveraging the intricate designs and mechanisms found in nature. Biomimetics, also known as “nature-inspired engineering”, involves studying and emulating biological systems to address complex human challenges. This comprehensive review provides insights into the latest trends in biomimetic prosthetics, focusing on leveraging knowledge from natural biomechanics, sensory feedback mechanisms, and control systems to closely mimic biological appendages. Highlighted breakthroughs include the integration of cutting-edge materials and manufacturing techniques such as 3D printing, facilitating seamless anatomical integration of prosthetic limbs. Additionally, the incorporation of neural interfaces and sensory feedback systems enhances control and movement, while technologies like 3D scanning enable personalized customization, optimizing comfort and functionality for individual users. Ongoing research efforts in biomimetics hold promise for further advancements, offering enhanced mobility and integration for individuals with limb loss or impairment. This review illuminates the dynamic landscape of biomimetic prosthetic technology, emphasizing its transformative potential in rehabilitation and assistive technologies. It envisions a future where prosthetic solutions seamlessly integrate with the human body, augmenting both mobility and quality of life.

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“…This replication is essential for enhancing cell adhesion, proliferation, and differentiation [ 12 ]. Specifically, composite materials used in regenerative medicine must possess attributes such as biocompatibility, bioactivity, appropriate surface characteristics (e.g., porosity or roughness), structural resemblance to the target tissue, and necessary mechanical properties [ 13 ]. The presence of biominerals can significantly benefit composite materials, as they serve as important building blocks.…”

Section: Introductionmentioning

confidence: 99%

Biomineral-Based Composite Materials in Regenerative Medicine

Kim,

Ki,

Han

et al. 2024

IJMS

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Regenerative medicine aims to address substantial defects by amplifying the body’s natural regenerative abilities and preserving the health of tissues and organs. To achieve these goals, materials that can provide the spatial and biological support for cell proliferation and differentiation, as well as the micro-environment essential for the intended tissue, are needed. Scaffolds such as polymers and metallic materials provide three-dimensional structures for cells to attach to and grow in defects. These materials have limitations in terms of mechanical properties or biocompatibility. In contrast, biominerals are formed by living organisms through biomineralization, which also includes minerals created by replicating this process. Incorporating biominerals into conventional materials allows for enhanced strength, durability, and biocompatibility. Specifically, biominerals can improve the bond between the implant and tissue by mimicking the micro-environment. This enhances cell differentiation and tissue regeneration. Furthermore, biomineral composites have wound healing and antimicrobial properties, which can aid in wound repair. Additionally, biominerals can be engineered as drug carriers, which can efficiently deliver drugs to their intended targets, minimizing side effects and increasing therapeutic efficacy. This article examines the role of biominerals and their composite materials in regenerative medicine applications and discusses their properties, synthesis methods, and potential uses.

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Recent Advances in the Development of Biomimetic Materials

Cited by 6 publications

References 235 publications

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Recent Advances in Biomimetics for the Development of Bio-Inspired Prosthetic Limbs

Biomineral-Based Composite Materials in Regenerative Medicine

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