Self‐assembling peptide matrix for treatment of dentin hypersensitivity: A randomized controlled clinical trial

Schlee, Markus; Rathe, Florian; Bommer, Claudine; Bröseler, Frank; Kind, Lucy

doi:10.1002/jper.17-0429

Cited by 17 publications

(22 citation statements)

References 27 publications

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“…Recent reports on favourable remineralisation after SAPM application have been published [18][19]. A randomised clinical trial investigating an SAPM Gel (as investigated in this report) demonstrated fast relief of DH compared to the other formulations evaluated [15]. An in vitro study by João-Souza et al [20] also compared the desensitizing effects of selected toothpastes-one daily toothpaste including a diluted SAPM formulation-under erosive conditions.…”

Section: Permeability Measurement (Hydraulic Conductance [Lp])mentioning

confidence: 82%

“…there is yet only one report of a randomised clinical trial comparing its clinical efficacy to that of the CSP product [15]. An additional in vitro study has evaluated a SAPM gel in a daily erosion toothpaste (with a much lower concentration of SAPM) [20], where the investigators reported that none of the desensitizing products showed any significant effects on tubular occlusion under the erosive conditions used.…”

Section: Permeability Measurement (Hydraulic Conductance [Lp])mentioning

confidence: 99%

“…The first product based on SAPM for treatment of Dentine Hypersensitivity (DH) has been marketed (Curodont D'Senz, Credentis ag, Switzerland). It has been recently shown to be effective in reducing DH in a randomised clinical study by Schlee et al [15], demonstrating faster desensitisation than a toothpaste including 5% Arginine and Calcium Carbonate. This product uses the same self-assembling peptide as included in the product for remineralisation carious lesion but was formulated as a gel with the self-assembling peptide in its assembled (i.e.…”

Section: Introductionmentioning

confidence: 99%

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An in vitro comparison of a novel Self-Assembling Peptide Matrix Gel and selected desensitizing toothpastes in reducing fluid flow by dentine tubular occlusion

Hill¹,

Chen²,

Lysek³

et al. 2019

Preprint

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Background: The objective of the present in vitro study was to evaluate the ability of a novel self-assembling peptide matrix gel with calcium phosphate in effectively occluding dentine tubules compared to selected desensitizing toothpastes. Methods: Mid-coronal dentine discs with a thickness of 1 mm were sectioned from caries-free human molars. The discs were etched with 6% citric acid for 2 minutes, halved and subjected to a 2-minute brushing with a novel gel (SAPM) and three selected desensitizing toothpastes ([SRP], [SRR] and [CSP]). The ability of the desensitizing gel and toothpastes to occlude the dentine tubules was assessed and compared before and after brushing using Scanning Electron Microscopy (SEM) on both etched and fractured dentine surfaces. The SEM observations were supplemented by hydraulic conductance measurements using a modified Pashley model before and after tooth brushing (n=5). Results: The results demonstrated that there was a reduction in both the number and the diameter of the open dentine tubules, which was evident for all the treated dentine discs. The particles that occluded the open dentine tubules, however had different morphologies and distribution. The self-assembling peptide matrix gel (SAPM) demonstrated the greater reduction in the number of open tubules compared to the other desensitizing toothpastes. Reductions in the hydraulic conductance measurements were observed for all tested materials (mean [SD, %]: SAPM 55.1 [12.5], SRP 64.9 [18.5], SRR 39.1 [17.1] and CSP 27.6 [6.8]). No statistically differences were observed between the SAPM and SRP, SRR toothpastes (paired t-Test; ≤0.05) although a significant difference was noted between the SAPM and the CSP toothpastes. There was an overall trend for reduction for the SAPM compared to the SRR toothpaste. Conclusion: The results would suggest that a novel self-assembling peptide matrix gel (SAPM) was effective in blocking the dentine tubules and may therefore have the potential to be an effective desensitizing product for the treatment of Dentine Hypersensitivity.

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Section: Permeability Measurement (Hydraulic Conductance [Lp])mentioning

confidence: 82%

Section: Permeability Measurement (Hydraulic Conductance [Lp])mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An in vitro comparison of a novel Self-Assembling Peptide Matrix Gel and selected desensitizing toothpastes in reducing fluid flow by dentine tubular occlusion

Hill¹,

Chen²,

Lysek³

et al. 2019

Preprint

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show abstract

“…Thus the matrix is bound to the tooth through electrostatic interactions. These interactions occlude the dentinal tubules and reduce dentinal hypersensitivity [41].…”

Section: Dentin Hypersensitivitymentioning

confidence: 99%

Self Assembling Peptide P11-4 for Enamel Remineralization: A Biomimetic Approach

Gulzar

Ajitha

Subbaiyan

2020

JPRI

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Treatment of caries through conventional modalities involves an invasive approach of excavation of the carious lesion followed by a restoration. This compromises on the strength and integrity of the tooth structure. Minimal invasive dentistry aims at early detection of the carious lesion and their remineralization. Self assembling peptides find its application in the medical field due to its ability to form a scaffold through a process of hierarchical organization into nano structures. Self-assembling peptide P11-4 is a novel technology for enamel remineralization through a biomimetic approach. The technology simulates normal enamel histogenesis. It induces de novo precipitation of hydroxyapatite crystals by forming a three dimensional scaffold matrix. The formation of the scaffold involves the conversion of the peptide from a low viscosity fluid to a nematic gel under low pH conditions. This scaffold matrix further attracts calcium ions and leads to formation of hydroxyapatite crystals. Being minimally invasive, it helps in preserving the strength and integrity of the tooth structure. The aim of the article is to review the technology of self assembling peptides for enamel regeneration and its potential as a material for successful treatment of early carious lesions through a minimally invasive approach.

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“…[9][10][11] Current materials for dentinal tubule occlusion include sodium fluoride/stannous fluoride, [12][13][14] strontium chloride/acetate, 15,16 potassium oxalate, [17][18][19] arginine, 20,21 calcium phosphate and its composites, [22][23][24][25][26][27][28][29][30][31] bioglass and silicates, [32][33][34][35][36][37][38][39][40][41][42][43] laser, 44,45 gallic acid (tannin)/Fe 3+ complex, 47,48 amyloid-like aggregation coating, 49 and selfassembly peptide. 51 Although some of these demonstrate clinical effectiveness in tooth desensitization, no treatment regimen presently exhibits long-lasting efficiency in treating DH. 46,[52][53][54][55][56]…”

Section: Introductionmentioning

confidence: 99%

Acidic Monetite Complex Paste with Bleaching Property for In-depth Occlusion of Dentinal Tubules

Liu¹,

Fang²,

Cao³

et al. 2021

IJN

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Self‐assembling peptide matrix for treatment of dentin hypersensitivity: A randomized controlled clinical trial

Cited by 17 publications

References 27 publications

An in vitro comparison of a novel Self-Assembling Peptide Matrix Gel and selected desensitizing toothpastes in reducing fluid flow by dentine tubular occlusion

An in vitro comparison of a novel Self-Assembling Peptide Matrix Gel and selected desensitizing toothpastes in reducing fluid flow by dentine tubular occlusion

Self Assembling Peptide P11-4 for Enamel Remineralization: A Biomimetic Approach

Acidic Monetite Complex Paste with Bleaching Property for In-depth Occlusion of Dentinal Tubules

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