Self Assembling Peptide P11-4 for Enamel Remineralization: A Biomimetic Approach

Abstract

Treatment of caries through conventional modalities involves an invasive approach of excavation of the carious lesion followed by a restoration. This compromises on the strength and integrity of the tooth structure. Minimal invasive dentistry aims at early detection of the carious lesion and their remineralization. Self assembling peptides find its application in the medical field due to its ability to form a scaffold through a process of hierarchical organization into nano structures. Self-assembling peptide P11-4 is a novel technology for enamel remineralization through a biomimetic approach. The technology simulates normal enamel histogenesis. It induces de novo precipitation of hydroxyapatite crystals by forming a three dimensional scaffold matrix. The formation of the scaffold involves the conversion of the peptide from a low viscosity fluid to a nematic gel under low pH conditions. This scaffold matrix further attracts calcium ions and leads to formation of hydroxyapatite crystals. Being minimally invasive, it helps in preserving the strength and integrity of the tooth structure. The aim of the article is to review the technology of self assembling peptides for enamel regeneration and its potential as a material for successful treatment of early carious lesions through a minimally invasive approach.

The Effect of Different Remineralizing Agents on Microleakage around Restored Demineralized Enamel: An In vitro Comparative Study

“…The scaffold matrix is responsible for this stability. This phenomenon imitates the process in which the enamel matrix proteins self-assemble prior to tooth eruption to direct the precipitation of hydroxyapatite crystals 7 . It is worth noting that the goal to be achieved in remineralizing systems is to reach the synergetic effect of calcium, phosphate with fluoride ions together 8 .…”

Assessment of Efficiency of Bioactive Glass, Self-Assembling Peptide, and Ozone Remineralising Agents on Artificial Carious Lesion

“…Due to the drawbacks of fluoride, such as skeletal fluorosis and dental fluorosis [2], numerous nonfluoridated remineralizing agents were studied such as Casein phosphopeptide amorphous calcium phosphate (CPP-ACFP), CCP-ACFP, biomimetic remineralization materials, theobromine, bioactive glass (BAG-Novamin), Xylitol, Ozone, Sensistatetc, tricalcium phosphte (TCP), self-assembling peptide, and Nanohydroxyapatite (nHAp) [2][3][4][6][7][8][9][10][11][12]. Various remineralizing agents are used for the noninvasive management of initial carious lesions.…”