Self-assembled polyelectrolyte systems

Kötz, Joachim; Kosmella, Sabine; Beitz, Toralf

doi:10.1016/s0079-6700(01)00016-8

Cited by 210 publications

(136 citation statements)

References 190 publications

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“…Therefore, in the absence of salt, PSS chains are essentially expanded and swollen. [28,29] With increase of ionic strength, PSS molecules 'shrink' to a more compact configuration due to a shielding effect of salt cations accompanied by decrease [30] of hydrodynamic radius (R H ) of the polyelectrolyte coil, [31,32] 'ejecting' a portion of solvent (water) and probably forming nonpolar regions. In combination with the formation of a supramolecular guest-host complex between Na + and a cavity formed by ethylene units and oxygen atoms of the crown ether in Mgcr 8 Pc, the generation of nonpolar (hydrophobic) regions in PSS provides an increase of the absorbance of the Q-band at l ~ 680 nm (spectral region of Pc monomer) even in the presence of single PSS.…”

Section: Supramolecular Organization Of Mgсr 8 Pc In Aqueous Environmmentioning

confidence: 99%

Supramolecular Organization of Magnesium Octa[(4’-benzo- 15-crown-5)oxy]phthalocyaninate in Aqueous Solutions of Polyelectrolytes and Surfactants: Analysis by Spectral Methods

Gol’dshleger¹,

Gak²,

Lobach³

et al. 2015

MHC

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Section: Supramolecular Organization Of Mgсr 8 Pc In Aqueous Environmmentioning

confidence: 99%

Supramolecular Organization of Magnesium Octa[(4’-benzo- 15-crown-5)oxy]phthalocyaninate in Aqueous Solutions of Polyelectrolytes and Surfactants: Analysis by Spectral Methods

Gol’dshleger¹,

Gak²,

Lobach³

et al. 2015

MHC

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“…They are of interest because of their fundamental and practical importance. PSCs are used in drug delivery systems [7], preparation of nanomaterials [8], cosmetics, foods, paints [9], solar cells [10], and so on [11,12].…”

Section: Introductionmentioning

confidence: 99%

Micellar polymerization of alkylammonium 2-acrylamido-2-methylpropane sulfonates in the solvents of different polarities and properties of resulting polyelectrolyte-surfactant complexes

et al. 2015

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Polymerization of formerly described novel surfmers polymerizable by counterion has been reported. D o d e c y l a m m o n i u m , c e t y l a m m o n i u m , a n d cetyltrimethylammonium 2-acrylamido-2-methylpropane sulfonates were polymerized in water-dioxane mixtures in a wide range of concentrations of the solvents and in some organic solvents as well. The resulting polyelectrolyte-surfactant complexes precipitated from water-dioxane mixtures. Molecular weights and polymerization yields of the products were the highest at high and low water contents in the reaction mixture, whereas the lowest polymerization degrees and yields conform to solutions, containing 20 % of water. It has been found that the morphology of the precipitated aggregates formed in low-polarity solvents differs considerably from that formed in water. Polymerization in organic media depends strongly on the polarity of the solvent. Contributions of electrostatic and hydrophobic interactions in the structure formation of the complexes were estimated qualitatively.

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“…Self-assembly of polymers is an important phenomenon used in the preparation of a better carrier system to deliver drug molecules (Kotz et al, 2001). Polyanions and polycations have been used to prepare self-assembled nano-and microstructures for various applications (Kotz et al, 2001;Ariga et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Polyanions and polycations have been used to prepare self-assembled nano-and microstructures for various applications (Kotz et al, 2001;Ariga et al, 2008). Self-assembly controlled through layer-by-layer (LbL) strategy has shown potential in preparation of delivery systems to smart sensors (Loh et al, 2007;Johnston et al, 2006;Yang et al, 2006;Hammond, 2011).…”

Section: Introductionmentioning

confidence: 99%

Influence of charge on encapsulation and release behavior of small molecules in self-assembled layer-by-layer microcapsules

et al. 2013

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ORIGINAL PAPERInfluence of charge on encapsulation and release behavior of small molecules in self-assembled layer-by-layer microcapsules Praveen K. Mandapalli, Suman Labala, Deekshith Vanamala, Manali P. Koranglekar, Lakshmi A. Sakimalla, and Venkata Vamsi K. Venuganti Department of Pharmacy, BITS Pilani, Hyderabad Campus, Shameerpet, Hyderabad 500078, Andhra Pradesh, India AbstractThe objective of this study is to investigate the influence of charge of model small molecules on their encapsulation and release behavior in layer-by-layer microcapsules (LbL-MC). Poly(styrene sulfonate) and poly(ethylene imine) were sequentially adsorbed on calcium carbonate sacrificial templates to prepare LbL-MC. Model molecules with varying charge, anionic -ascorbic acid, cationic -imatinib mesylate (IM) and neutral -5-fluorouracil were encapsulated in LbL-MC. Free and encapsulated LbL-MC were characterized using zetasizer, FTIR spectroscope and differential scanning calorimeter. The influence of IM-loaded LbL-MC on cell viability was studied in B16F10 murine melanoma cells. Furthermore, biodistribution of IM-loaded LbL-MC with and without PEGylation was studied in BALB/c mice. Results showed spherical LbL-MC of 3.0 AE 0.4 mm diameter. Encapsulation efficiency of LbL-MC increased linearly (R 2 ¼ 0.89-0.99) with the increase in solute concentration. Increase in pH from 2 to 6 increased the encapsulation of charged molecules in LbL-MC. Charged molecules showed greater encapsulation efficiency in LbL-MC compared with neutral molecule. In vitro release kinetics showed Fickian and non-Fickian diffusion of small molecules, depending on the nature of molecular interactions with LbL-MC. At 50 mM concentration, free IM showed significantly (p50.05) more cytotoxicity compared with IM-loaded LbL-MC. Biodistribution studies showed that PEGylation of LbL-MC decreased the liver and spleen uptake of IM-encapsulated LbL-MC. In conclusion, LbL-MC can be developed as a potential carrier for small molecules depending on their physical and chemical properties.

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Self-assembled polyelectrolyte systems

Cited by 210 publications

References 190 publications

Supramolecular Organization of Magnesium Octa[(4’-benzo- 15-crown-5)oxy]phthalocyaninate in Aqueous Solutions of Polyelectrolytes and Surfactants: Analysis by Spectral Methods

Supramolecular Organization of Magnesium Octa[(4’-benzo- 15-crown-5)oxy]phthalocyaninate in Aqueous Solutions of Polyelectrolytes and Surfactants: Analysis by Spectral Methods

Micellar polymerization of alkylammonium 2-acrylamido-2-methylpropane sulfonates in the solvents of different polarities and properties of resulting polyelectrolyte-surfactant complexes

Influence of charge on encapsulation and release behavior of small molecules in self-assembled layer-by-layer microcapsules

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