Supramolecular Organization of Magnesium Octa[(4’-benzo- 15-crown-5)oxy]phthalocyaninate in Aqueous Solutions of Polyelectrolytes and Surfactants: Analysis by Spectral Methods

Abstract

The behavior of magnesium octa [(4'-benzo-15-crown-5 [(4'-бензо-15-краун-5

Сrown- and Sulfophthalocyanines in Low-Molecular-Weight Hydrogels: Properties, Molecular State, and Release

“…[11] Upon a change in the aggregation state of the system (gel melting), Mgcr 8 Pc (Zncr 8 Pc or Mgcr 4 Pc) undergoes transition from solution suggest that the formation of micelle-bound Mgcr 8 Pc monomer is possible (i) upon synergic complexation of Na + ions with crown fragments in Mgcr 8 Pc, (ii) due to electrostatic interaction between the polar -ОSO 3 − group the aggregated to monomeric state; as a result, the fluorescence intensity of Mgcr 8 Pc grows. [12] Another way to go about releasing the active agent is a decrease in the strength of SDC/NaCl gel by addition of amino acids with a high hydropathy index. [28] In vitro experiments, L-lysine and L-arginine (hydropathy indices -3.9 and -4.5) [34,35] led to the disruption of non-covalent interactions and hence to weakening the mechanical strength of SDC-based supramolecular gel, which resulted in the release of active component, methylene blue, [25] or Pc in our case (see Figures 13 and 14).…”

“…The important role of bile salts in the assimilation and delivery of drugs was discussed in reviews. [9,10] The solubilization of magnesium octa[(4'-benzo-15-crown-5)-oxy]phthalocyanine (Mgcr 8 Pc) in micellar solutions of SDC [11] ensures the embedding of Mgcr 8 Pc (Figure 1) into supramolecular gels of SDC [12] at the values of pH and ionic strength close to environment-friendly physiological ones.…”