Self-assembled MXene-based Schottky-junction upon Transition metal oxide for regulated tumor microenvironment and enhanced CDT/PTT/MRI activated by NIR irradiation

Schottky Junction Nanozyme Based on Mn-Bridged Co-Phthalocyanines and Ti3C2Tx Nanosheets Boosts Integrative Type I and II Photosensitization for Multimodal Cancer Therapy

“…Most recently, Schottky junctions prepared by integrating inorganic metals and semiconductors via tight contact have demonstrated value for applications including optoelectronics, energy storage, and nanomedicine due to the high photoabsorption ability and superior separation of photoinduced charges. − However, only a few Schottky junctions such as Ti 3 C 2 @chitosan-MnFe 2 O 4 and Ag/AgCl NPs have been used as multimodal bioplatforms for antitumor therapy. As an important category of PSs, phthalocyanine (Pc) molecules, with electronic delocalization of 18 electrons, possess distinct and high-efficiency near-infrared (NIR) light absorption, low phototoxicity, and high extinction owing to their highly conjugated planar structures and ability to coordinate with a diversity of metal ions .…”

DOTAREM (DOTA)–Gold-Nanoparticles: Design, Spectroscopic Evaluation to Build Hybrid Contrast Agents to Applications in Nanomedecine

“…In theranostic, the combination of MRI imaging and PTT therapy using iron, gadolinium or titanium based nanoparticles was already demonstrated in several works. [36][37][38][39] In addition to its imaging properties as an MRI contrast agent, DOTA IN-CTL AuNPs shows high thermoplasmonic properties due to their gold nature during their irradiation under an 808 nm laser wavelength (Figure 5A). Despite the shift between the excitation wavelength (808 nm) and the nanoparticles LSPR (540 nm), PTT is very effective as already demonstrated in various published works.…”

Calcination-controlled performance optimization of iron–vanadium bimetallic oxide nanoparticles for synergistic tumor therapy

“…1–3 Among them, transition metal oxide nanomaterials attract much attention because of their multivalent properties. 4–6 It is worth noting that the different morphologies and structures of transition metal oxide nanoparticles endow them with different properties and biotherapeutic abilities. 7,8 For example, Zhao et al 9 modulated the local electron density by building electron levers in perovskite nanocrystals for intensive chemodynamic therapy, and Yu et al 10 also investigated that defect engineering enabled mimetic enzyme active centers to act synergistically for efficient tumor therapy.…”