Cancer phototheranostics have the potential for significantly improving the therapeutic effectiveness, as it can accurately diagnose and treat cancer. However, the current phototheranostic platforms leave much to be desired and are often limited by tumor hypoxia. Herein, a Schottky junction nanozyme has been established between a manganese-bridged cobalt−phthalocyanines complex and Ti 3 C 2 T x MXene nanosheets (CoPc-Mn/Ti 3 C 2 T x ), which can serve as an integrative type I and II photosensitizer for enhancing cancer therapeutic efficacy via a photoacoustic imaging-guided multimodal chemodynamic/photothermal/photodynamic therapy strategy under near-infrared (808 nm) light irradiation. The Schottky junction not only possessed a narrow-bandgap, enhanced electron−hole separation ability and exhibited a potent redox potential but also enabled improved H 2 O 2 and O 2 supplying performances in vitro. Accordingly, the AS1411 aptamer-immobilized CoPc-Mn/Ti 3 C 2 T x nanozyme illustrated high accuracy and excellent anticancer efficiency through a multimodal therapy strategy in in vitro and in vivo experiments. This work presents a valuable method for designing and constructing a multifunctional nanocatalytic medicine platform for synergistic cancer therapy of solid tumors. KEYWORDS: multimodal cancer therapy, Schottky junction nanozyme, Ti 3 C 2 T x nanosheets, cobalt phthalocyanine, supply of O 2 and H 2 O 2
A novel multimodal antibacterial platform is constructed by the in situ growth of a bioactive zinc-based metal-organic framework (Zn-MOF) using the natural antibacterial agent (curcumin) as ligand over the Ti 3 C 2 T x nanosheets (NSs) for highly effective bacteria-infected wound healing. As Zn nodes in Zn-MOF can be partially exchanged by Ti sites in Ti 3 C 2 T x NSs, a novel oxygen vacancy-rich Schottky junction is formed at the interface between Zn-MOF and Ti 3 C 2 T x NSs, which can remarkably improve the separation and electron transfer efficiency of photoinduced carriers under near-infrared light irradiation (808 nm). Consequently, it affords the Zn-MOF@Ti 3 C 2 T x Schottky junction abundant superoxide radicals (•O 2 À ) and hydroxyl radicals (•OH) by electron transfer via type I mechanism and singlet oxygen ( 1 O 2 ) by energy transfer via type II mechanism, accompanying the superior photothermal performance and controllable release of Zn 2þ ions and curcumin. The Zn-MOF@Ti 3 C 2 T x shows excellent biocompatibility and multimodal antibacterial ability toward Staphylococcus aureus and Escherichia coli. Based on the detailed investigations of the antibacterial mechanism, the Zn-MOF@Ti 3 C 2 T x Schottky junction remarkably demonstrates accelerated wound healing (wound closure ratio is >99%) infected by S. aureus.
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