Self-assembled composite microparticles with surface protrudent porphyrin nanoparticles enhance cellular uptake and photodynamic therapy

Zhang, Wenbo; Li, Huiying; Qin, Ying; Gao, Changyou

doi:10.1039/c7mh00420f

Cited by 18 publications

(8 citation statements)

References 71 publications

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“…Recently, much effort has been paid to the development of high-performance photosensitizers, which have high absorption coefficient, high singlet oxygen ( 1 O 2 ) generation efficiency, nontoxicity in the dark, high photoluminescence quantum efficiency (PLQY), and excellent photostability such that they can be used for bioimaging and as an efficient therapeutic agent for PDT simultaneously. − A variety of photosensitizers have been developed, such as quantum dots or nanoparticles composed of polymers, gold, silica, porphyrin derivatives, and aggregation-induced emission fluorophores. − The nanoparticles based on conjugated polymer can be facilely prepared by encapsulating conjugated polymers with amphiphilic molecules, which typically have size in the range of several to tens of nanometers. In particular, these nanoparticles are of great interests owing to their high extinction coefficients, readily tunable light harvesting properties, and remarkable biocompatibility. − It has been reported that conjugated polymers consisting of an electron-withdrawing dibenzothiophene- S , S -dioxide (SO) moiety presented a high PLQY and excellent thermal and photostability.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Bioimaging and Photodynamic Therapy Based on Two-Photon Fluorescent Conjugated Polymers Containing Dibenzothiophene-S,S-dioxide Derivatives

Chen

Liu

et al. 2020

ACS Appl. Mater. Interfaces

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As a critical component for photodynamic therapy toward cancer treatment, photosensitizers require high photoinduced reactive oxygen species generation efficiency, good biocompatibility, and high phototoxicity. Herein, a series of donor−acceptor conjugated polymers containing dibenzothiophene-S,Sdioxide derivatives are designed and synthesized, which can be used as effective photosensitizers. The resulting copolymer PTA5 shows strong green light emission with high photoluminescence quantum yields owing to the intercrossed excited state of local existed and charge transfer states. The PTA5 nanoparticles can be fabricated by encapsulation with a biocompatible polymer matrix. Upon excitation at 800 nm, these nanoparticles present a relatively large two-photon absorption cross section of 3.29 × 10 6 GM. These nanoparticles also exhibit good photostability in water and thus can be utilized for bioimaging. The tissuepenetrating depths of up to 170 μm for hepatic vessels and 380 μm for blood vessels of mouse ear were achieved using PTA5 nanoparticles. Furthermore, PTA5 nanoparticles show impressive reactive oxygen species generation capability under the irradiation of a white light source. This can be attributed to the effective intersystem crossing between high-level excited state. Upon irradiation with white light (400−700 nm) at 50 mW cm −2 for 5 min every other day, the tumor growth can be effectively suppressed in the presence of PTA5 nanoparticles. These findings demonstrate that PTA5 nanoparticles can be used as a photosensitizer for photodynamic therapy.

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Section: Introductionmentioning

confidence: 99%

In Vivo Bioimaging and Photodynamic Therapy Based on Two-Photon Fluorescent Conjugated Polymers Containing Dibenzothiophene-S,S-dioxide Derivatives

Chen

Liu

et al. 2020

ACS Appl. Mater. Interfaces

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“…Their surface was quite rough (Figure A, inset). The rough surface is beneficial for their cellular uptake by cells because the particle surface roughness can promote their adhesion on the cell membrane and engulfment, likely due to the large interaction area and adhesive strength between the particles and biomembranes. − The particles had a solid internal structure and a thin film coating on the surface, demonstrating the successful assembly of the multilayers (Figure B). UV irradiation did not cause obvious changes in the size and morphology of the particles (Figure C), as has been reported previously .…”

Section: Resultsmentioning

confidence: 99%

Phototriggered N₂-Generating Submicron Particles for Selective Killing of Cancer Cells

Zhang

et al. 2017

ACS Appl. Mater. Interfaces

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Killing of cancer cells by applying mechanical disruption has been an appealing emerging strategy for cancer treatment in recent years. In this study, photoresponsive submicron particles based on diazo-resin that are able to release N under UV irradiation were prepared through a polyamine-salt aggregation method. After surface modification with hyaluronic acid, the particles could be internalized selectively by cancer cells and were mainly located in lysosomes after 6 h incubation. The viability of cancer cells decreased obviously after they were co-cultured with photoresponsive particles and UV irradiation due to the integrity damage of lysosomes by phototriggered N generation and the subsequent increased number of reactive oxygen species.

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“…Nanoparticles and nanomaterials have increasingly found practical applications in several fields and possess the capacity to change the methods of diagnostics or therapeutics currently in use [ 24 , 197 ]. Biocompatibility refers to the ability of a biomaterial to perform its desired function with respect to medical therapy, without eliciting any undesirable local or systemic effects in the recipient or beneficiary of that therapy, while generating the most suitable beneficial cellular or tissue response in that specific situation and optimizing the clinically relevant performance of that therapy [ 198 ].…”

Section: Biocompatibilitymentioning

confidence: 99%

The Nanosystems Involved in Treating Lung Cancer

Crintea

Duţu

Samaşcă

et al. 2021

Life

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Even though there are various types of cancer, this pathology as a whole is considered the principal cause of death worldwide. Lung cancer is known as a heterogeneous condition, and it is apparent that genome modification presents a significant role in the occurrence of this disorder. There are conventional procedures that can be utilized against diverse cancer types, such as chemotherapy or radiotherapy, but they are hampered by the numerous side effects. Owing to the many adverse events observed in these therapies, it is imperative to continuously develop new and improved strategies for managing individuals with cancer. Nanomedicine plays an important role in establishing new methods for detecting chromosomal rearrangements and mutations for targeted chemotherapeutics or the local delivery of drugs via different types of nano-particle carriers to the lungs or other organs or areas of interest. Because of the complex signaling pathways involved in developing different types of cancer, the need to discover new methods for prevention and detection is crucial in producing gene delivery materials that exhibit the desired roles. Scientists have confirmed that nanotechnology-based procedures are more effective than conventional chemotherapy or radiotherapy, with minor side effects. Several nanoparticles, nanomaterials, and nanosystems have been studied, including liposomes, dendrimers, polymers, micelles, inorganic nanoparticles, such as gold nanoparticles or carbon nanotubes, and even siRNA delivery systems. The cytotoxicity of such nanosystems is a debatable concern, and nanotechnology-based delivery systems must be improved to increase the bioavailability, biocompatibility, and safety profiles, since these nanosystems boast a remarkable potential in many biomedical applications, including anti-tumor activity or gene therapy. In this review, the nanosystems involved in treating lung cancer and its associated challenges are discussed.

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Self-assembled composite microparticles with surface protrudent porphyrin nanoparticles enhance cellular uptake and photodynamic therapy

Abstract: Microparticles with surface protrudent porphyrins enhance cell internalization, producing massive intracellular ROS and thereby leading to efficient photodynamic cell death.

Cited by 18 publications

References 71 publications

In Vivo Bioimaging and Photodynamic Therapy Based on Two-Photon Fluorescent Conjugated Polymers Containing Dibenzothiophene-S,S-dioxide Derivatives

In Vivo Bioimaging and Photodynamic Therapy Based on Two-Photon Fluorescent Conjugated Polymers Containing Dibenzothiophene-S,S-dioxide Derivatives

Phototriggered N₂-Generating Submicron Particles for Selective Killing of Cancer Cells

The Nanosystems Involved in Treating Lung Cancer

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Self-assembled composite microparticles with surface protrudent porphyrin nanoparticles enhance cellular uptake and photodynamic therapy

Abstract: Microparticles with surface protrudent porphyrins enhance cell internalization, producing massive intracellular ROS and thereby leading to efficient photodynamic cell death.

Cited by 18 publications

References 71 publications

In Vivo Bioimaging and Photodynamic Therapy Based on Two-Photon Fluorescent Conjugated Polymers Containing Dibenzothiophene-S,S-dioxide Derivatives

In Vivo Bioimaging and Photodynamic Therapy Based on Two-Photon Fluorescent Conjugated Polymers Containing Dibenzothiophene-S,S-dioxide Derivatives

Phototriggered N2-Generating Submicron Particles for Selective Killing of Cancer Cells

The Nanosystems Involved in Treating Lung Cancer

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Phototriggered N₂-Generating Submicron Particles for Selective Killing of Cancer Cells