Selenium stimulates estradiol production in bovine granulosa cells: possible involvement of nitric oxide☆

Basini, Giuseppina; Tamanini, Carlo

doi:10.1016/s0739-7240(99)00059-4

Cited by 105 publications

(61 citation statements)

References 49 publications

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“…Furthermore, FSH receptor expression and biosynthetic pathway of estradiol were predominantly influenced by selenium (Basini & Tamanini, 2000). Selenium can also stimulate luteal cell proliferation and decrease toxic lipid peroxides, and consequently elevate progesterone level affecting luteal cells (Kamada & Hodate, 1998;Kamada & Ikumo, 1997).…”

Section: Discussionmentioning

confidence: 99%

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

Rezvanfar

Saeedi

Mansoori

et al. 2015

Pharmaceutical Biology

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Submit your article to this journal Results: PCO rats exhibited ovarian cystogenesis which was preserved by the application of carvedilol and ANGIPARSä. In comparison with controls, decreased level of the total antioxidant power (TAP) and higher levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) in serum and ovaries (2.41 ± 0.67 versus 0.72 ± 0.11; and 0.17 ± 0.04 versus 0.05 ± 0.01; 5.48 ± 1.30 versus 10.56 ± 0.77; and 7.06 ± 1.94 versus 17.98 ± 0.98; p50.05, respectively) were detected in PCO rats. Moreover, the PCO rats exhibited hyperandrogenism due to a 3.7-fold increase in serum testosterone concentration (35.04 ± 3.17 versus 131.09 ± 13.24; p50.05) along with a 2.98-fold decrease in serum progesterone (6.19 ± 0.40 versus 18.50 ± 1.03; p50.05) and 5.2-fold decrease in serum estradiol (9.30 ± 0.61 versus 48.3 ± 2.10; p50.05) when compared with those of the control group. However, similar to the control group, normal levels of OS markers and sex hormones were detected in ANGIPARSä and carvedilol co-treated PCO rats. Besides, when compared with controls, increased levels of TNF-a (770.75 ± 42.06 versus 477.14 ± 28.77; p50.05) and insulin (1.27 ± 0.10 versus 0.36 ± 0.05; p50.05) in PCO rats were significantly inhibited by carvedilol and ANGIPARSä co-treatment. Discussion and conclusion: We evidenced the beneficial effects of carvedilol and ANGIPARSä in PCO, which underpin the new alternative approach in using these kinds of medicines in female reproductive disorders.

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Section: Discussionmentioning

confidence: 99%

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

Rezvanfar

Saeedi

Mansoori

et al. 2015

Pharmaceutical Biology

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“…Since these enzymes are active in mature oocytes, it seems that oocytes also have their own capacity to control ROS production during maturation by their antioxidant system [29][30][31]. Basini and Tamanini [32] showed that Se stimulated proliferation of bovine granulosa cells and had some stimulatory effects on estradiol secretion. In this study, the effect of the antioxidation was seen during in vitro maturation of oocytes, and this was agreement with these previous results.…”

Section: Discussionmentioning

confidence: 99%

Selenium and Vitamin E Improve the <i>In Vitro</i> Maturation, Fertilization and Culture to Blastocyst of Porcine Oocytes

et al. 2012

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Abstract. Selenium (Se) and vitamin E (Vit-E), as integral parts of antioxidant systems, play important roles for sperm and embryos in vitro. In this study, the effects of Se and Vit-E on the maturation, in vitro fertilization and culture to blastocysts of porcine oocytes and accumulation of ammonia in the culture medium during different development stages were investigated. The maturation was performed in modified tissue culture medium (mTCM)-199 supplemented with 10% (v/v) porcine follicular fluid, the fertilization medium was modified Tyrode's albumin lactate pyruvate (mTALP), and the embryo culture medium was modified North Carolina State University (mNCSU)-23. Se in the form of sodium selenite (SS) and seleon-L-methionine (SeMet) and Vit-E at different concentrations were also used. The incorporation and oxidation of 14 C(U)-glucose were assessed with a liquid scintillation counter. In this study, SeMet and SeMet+Vit-E increased oocyte maturation, fertilization and incorporation and oxidation of 14 C(U)-glucose significantly (P<0.05) compared with the control and other treatments. In addition, embryo development, specifically in terms of the numbers of morulae and blastocysts, significantly increased (P<0.05) with SeMet and SeMet+Vit-E. In contrast, the accumulation of ammonia was reduced with SeMet and SeMet+Vit-E compared with other treatments. These findings indicate that SeMet and SeMet+Vit-E may play important roles in reducing the accumulation of ammonia and subsequently in increasing the rate of maturation of porcine oocytes and fertilization, as well as development of the blastocyst and utilization of glucose in in vitro maturation, fertilization and culture to blastocysts of porcine oocytes.

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“…Deficiency of sepp1a has been linked to impaired spermatogenesis and infertility in male mammals (e.g., Renko et al, 2008). While a similar linkage has not been established for ovary, selenium has been reported to modulate granulosa cell proliferation and estradiol production (Basini and Tamanini, 2000). The large fold change in expression between the prevtg and mature classes suggests that sepp1a may play an important role in oogenesis and/or be involved in distributing Se, as a key micronutrient, to the oocytes.…”

Section: Notable Differentially Expressed Genesmentioning

confidence: 99%

Influence of ovarian stage on transcript profiles in fathead minnow (Pimephales promelas) ovary tissue

et al. 2010

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Selenium stimulates estradiol production in bovine granulosa cells: possible involvement of nitric oxide☆

Cited by 105 publications

References 49 publications

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

Selenium and Vitamin E Improve the <i>In Vitro</i> Maturation, Fertilization and Culture to Blastocyst of Porcine Oocytes

Influence of ovarian stage on transcript profiles in fathead minnow (Pimephales promelas) ovary tissue

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