Selenium-Rich Yeast Mitigates Aluminum-Mediated Testicular Toxicity by Blocking Oxidative Stress, Inhibiting NO Production, and Disturbing Ionic Homeostasis

Cao, Changyu; Zhang, Haoji; Wang, Kai; Li, Xinran

doi:10.1007/s12011-019-01820-5

Cited by 18 publications

(13 citation statements)

References 39 publications

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“…38 Moreover, maternal Se deficiencies alter the fetal development and predispose the adult offspring to thyroid dysfunction and fetal growth restriction via the alterations of mitochondrial protein expression. 39 Due to the key effect of mitochondrial dysfunctions induced by Se deficiencies on disease progression, the supplementation of antioxidant compounds including sodium selenite (Na 2 SeO 3 ), sodium selenate (Na 2 SeO 4 ) and Se enriched yeast (SY) has been applied to ameliorate the oxidative stress damage caused by the exposure of bisphenol A (BPA), 40 doxorubicin, 41 monosodium glutamate, 42 aluminum, 43 docetaxel (DTX), 44 sodium azide (SA) 45 and aflatoxin B1 (AFB1) 46 via the promotion of mitochondrial functions. Furthermore, the artificial selenylation modifications of polymannuronate, polysaccharides and galactomannan (GM) have been confirmed to promote neuroprotection, 47,48 antiinflammatory, 49,50 anti-tumor activity, 51,52 hepatic protection 53,54 and antiglycative activity 55 of these biopolymers via the promotion of antioxidant defense system.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effect of Selenium Doped Carbon Quantum Dots Supplementation on the in vitro Development Competence of Ovine Oocytes

Wang¹,

Ren²,

Liu³

et al. 2022

IJN

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Background: After the synthesis of selenium doped carbon quantum dots (Se/CDs) via a step-by-step hydrothermal synthesis method with diphenyl diselenide (DPDSe) as precursor, the beneficial effects of Se/CDs' supplementation on the in vitro development competence of ovine oocytes were firstly investigated in this study by the assay of maturation rate, cortical granules' (CGs) dynamics, mitochondrial activity, reactive oxygen species (ROS) production, epigenetic modification, transcript profile, and embryonic development competence. Results:The results showed that the Se/CDs' supplementation during the in vitro maturation (IVM) process not only enhanced the maturation rate, CGs' dynamics, mitochondrial activity and embryonic developmental competence of ovine oocytes, but remarkably decreased the ROS production level of ovine oocytes. In addition, the expression levels of H3K9me3 and H3K27me3 in the ovine oocytes were significantly up-regulated after the Se/CDs' supplementation, in consistent with the expression levels of 5mC and 5hmC. Moreover, 2994 up-regulated differentially expressed genes (DEGs) and 846 repressed DEGs were found in the oocytes after the Se/ CDs' supplementation. According to the analyses of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), these DEGs induced by the Se/CDs' supplementation were positively related to the progesterone mediated oocyte maturation and mitochondrial functions. And these remarkably up-regulated expression levels of DEGs related to oocyte maturation, mitochondrial function, and epigenetic modification induced by the Se/CDs' supplementation further confirmed the beneficial effect of Se/CDs' supplementation on the in vitro development competence of ovine oocytes. Conclusion:The Se/CDs prepared in our study significantly promoted the in vitro development competence of ovine oocytes, benefiting the extended research about the potential applications of Se/CDs in mammalian breeding technologies.

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Section: Discussionmentioning

confidence: 99%

Beneficial Effect of Selenium Doped Carbon Quantum Dots Supplementation on the in vitro Development Competence of Ovine Oocytes

Wang¹,

Ren²,

Liu³

et al. 2022

IJN

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“…Aluminum can produce reproductive toxicity in female and male rodents. Studies that were GLP compliant and followed Sakr et al (2017) 8 339 Adedosu et al (2018) 16 339 Mouro et al (2018) 0.000134, 0.00067, 20, or 80 0.015, 0.075, 2240, or 8960 Sun et al (2018) 25, 52, or 103 3103, 6205, or 12,411 Gomes et al (2019 40 323 Olawuyi et al (2019) 0.2 4.2 Yuan et al (2019) 15, 30 or 59 1653, 3307, or 6613 Cao et al (2020) 20 560 G€ uvenç et al 202014 962 Sajjad et al (2020) 20.2 909 E. Study found some statistically significant results from higher exposure Melograna and Yokel (1984) 3400 68,000 Oneda et al (1994) 114, 285, 570, or 114069,312, 173,280, 346,560, or 693,120 Llobet et al (1995 3600, 7200, or 14,400 72,000, 144,000, or 288,000 Guo et al (2001) 13,000 or 35,000 182,000 or 490,000 Guo et al (2002) 13,000 or 35,000 182,000 or 490,000 Guo et al (2005a) 35,000 420,000 Guo et al (2005b) 1470 or 2730 20,580 or 38,220 Guo et al (2006) 1470 or 7350 20,580 or 102,900 Reza and Palan (2006) 10,100 202,000 Khattab (2007) 3030 or 6060 53,025 or 105,050 Kutlubay et al (2007) 339 4790 Guo et al (2009) 1414 or 7070 19,796 or 98,980 Cui et al (2009) 7214, 10,821, or 14,428 72,140, 108,210, or 144,280 Buraimoh et al (2012b 768 42,986 Abdel-Moneim (2013) 5050 5050 Chen et al (2014) 577, 1154, or 17311731, 3464, or 5194 D'Souza et al (2014) 6600, 13,200, or 19,800 46,200, 92,400, or 138,600 Maghraoui et al (2014 1778 24,892 Al…”

Section: Discussionmentioning

confidence: 99%

Aluminum reproductive toxicity: a summary and interpretation of scientific reports

Yokel

2020

Critical Reviews in Toxicology

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Publications addressing aluminum (Al)-induced reproductive toxicity were reviewed. Key details were compiled in summary tables. Approximate systemic Al exposure, a measure of bioavailability, was calculated for each exposure, based on the Al percentage in the dosed Al species, Al bioavailability, and absorption time course reports for the exposure route. This was limited to laboratory animal studies because no controlled-exposure human studies were found. Intended Al exposure was compared to unintended dietary Al exposure. The considerable and variable Al content of laboratory animal diets creates uncertainty about reproductive function in the absence of Al. Aluminum-induced reproductive toxicity in female mice and rats was evident after exposure to !25-fold the amount of Al consumed in the diet. Generally, the additional daily Al systemic exposure of studies that reported statistically significant results was greater than 100-fold above the typical human daily Al dietary consumption equivalent. Male reproductive endpoints were significantly affected after exposure to lower levels of Al than females. Increased Al intake increased fetus, placenta, and testes Al concentrations, to a greater extent in the placenta than fetus, and, in some cases, more in the testes than placenta. An adverse outcome pathway (AOP) was constructed for males based on the results of the reviewed studies. The proposed AOP includes oxidative stress as the molecular initiating event and increased malondialdehyde, DNA and spermatozoal damage, and decreased blood testosterone and sperm count as subsequent key events. Recommendations for the design of future studies of reproductive outcomes following exposure to Al are provided.

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“…Khattab and Khattab () have reported that Al‐induced oxidative damage and Al's capacity to cross the blood–testis barrier induced lipid peroxidation, damaging the biological membranes. Studies show that Al increases the lipid peroxidation, causing oxidative cell damage and provokes the reproductive toxicity (Cao, Zhang, Wang, & Li, ; Zhuang et al, ). It has been reported that the decrease in the antioxidant capacity in testes can occur owing to the capture of free radicals accumulated in this tissue (Morielli & O'Flaherty, ).…”

Section: Discussionmentioning

confidence: 99%

Tyrosol prevents AlCl₃induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway

et al. 2019

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Aluminium is a ubiquitous element that occurs naturally in the soil making human exposure to it is unavoidable. Tyrosol is present in olive oil and is known to have antioxidant effects. Therefore, the present study explores the toxic effects of aluminium chloride (AlCl3) and evaluates the possible protection by tyrosol in male rats. Testicular injury was induced by the administration of AlCl3 (34 mg kg−1 day−1). Rats were treated with either tyrosol (20 mg kg−1 day−1) or AlCl3 (34 mg kg−1 day−1). The experiment lasted for 10 weeks. Biochemical, histopathological and protein expression profiles were determined to decipher the role of tyrosol in protecting the cellular damage. Further, histomorphometric analyses of testes showed deranged architecture along with other noted abnormalities. AlCl3 group rats' testes showed decreased GSH levels, CAT activities, Nrf‐2, HO‐1, bcl‐2 expressions and sperm motility whereas increased caspase‐3 expressions, MDA levels, abnormal and dead/live sperm ratio. However, tyrosol treatment attenuated these changes. The present results demonstrate the beneficial role of tyrosol treatment in AlCl3 induced testicular toxicity alterations of rat.

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Selenium-Rich Yeast Mitigates Aluminum-Mediated Testicular Toxicity by Blocking Oxidative Stress, Inhibiting NO Production, and Disturbing Ionic Homeostasis

Cited by 18 publications

References 39 publications

Beneficial Effect of Selenium Doped Carbon Quantum Dots Supplementation on the in vitro Development Competence of Ovine Oocytes

Beneficial Effect of Selenium Doped Carbon Quantum Dots Supplementation on the in vitro Development Competence of Ovine Oocytes

Aluminum reproductive toxicity: a summary and interpretation of scientific reports

Tyrosol prevents AlCl₃induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway

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Selenium-Rich Yeast Mitigates Aluminum-Mediated Testicular Toxicity by Blocking Oxidative Stress, Inhibiting NO Production, and Disturbing Ionic Homeostasis

Cited by 18 publications

References 39 publications

Beneficial Effect of Selenium Doped Carbon Quantum Dots Supplementation on the in vitro Development Competence of Ovine Oocytes

Beneficial Effect of Selenium Doped Carbon Quantum Dots Supplementation on the in vitro Development Competence of Ovine Oocytes

Aluminum reproductive toxicity: a summary and interpretation of scientific reports

Tyrosol prevents AlCl3induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway

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Product

Resources

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Tyrosol prevents AlCl₃induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway