Selenium—Its biological perspectives

Bedwal, R. S.; Nair, Neena; Sharma, Mahima; Mathur, Rati

doi:10.1016/0306-9877(93)90062-u

Cited by 64 publications

(37 citation statements)

References 90 publications

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“…Methyl-mercury enhances selenium deficiency but inorganic mercury increases methylated-selenium toxicity. At intakes of 4 -8 mg kg -1 , selenium increases the copper contents of the heart, liver and kidneys but has a detoxifying or protective effect against cadmium and mercury ( WHO, 1987;Bedwal et al, 1993).…”

Section: F Selenium Toxicity -Effects In Humansmentioning

confidence: 99%

Selenium Deficiency and Toxicity in the Environment

Fordyce

2012

Essentials of Medical Geology

384

363

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Section: F Selenium Toxicity -Effects In Humansmentioning

confidence: 99%

Selenium Deficiency and Toxicity in the Environment

Fordyce

2012

Essentials of Medical Geology

384

363

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“…Oxygen is essential for all aerobic organisms whose metabolism leads to the formation of harmful free radicals and other reactive oxygen species (ROS) The trace elements function as prosthetic groups of various enzymes (9). Selenium is incorporated into the active site of glutathione peroxidase(10).…”

Section: Discussionmentioning

confidence: 99%

Blood glutathione peroxidase and selenium in abortion

Mishra

Chaudhuri

2003

Indian J Clin Biochem

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This study was carried out to estimate the levels of glutathione peroxidase and selenium in blood of abortion cases. Glutathione peroxidase and selenium were determined in 52 abortion cases (22 in 1 St trimester, 30 in second trimester), 45 normal pregnant cases and 25 nonpregnant control cases. The selenium concentration in whole blood and plasma in abortion cases was almost the same as in normal pregnant women but significantly low when compared with the control non-pregnant group. The glutathione levels was higher in abortion cases when compared with normal pregnant and non-pregnant control groups. Red cell and plasma glutathione peroxidase activities of women who had abortion were significantly lower compared with both non-pregnant control group and normal pregnancies.

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“…Survival in the presence of oxygen is thus dependent on the prevention of oxidative damage by enzymes. In general, trace elements function as prosthetic groups of various enzymes 32 . Selenium is incorporated into the active site of glutathione-Px 33±34 .…”

Section: Discussionmentioning

confidence: 99%

“…Copper, zinc and manganese are constituents of superoxide dismutase 35 , which plays a major role in catalysing the transformation of superoxide radical anion to less harmful H 2 O 2 36 . Glutathione-Px catalyses the reduction of H 2 O 2 and organic hydroperoxides, thus preventing lipid peroxidation of cell membranes and acting as a free radical scavenger 32 . Oxidative stress, of which lipid peroxidation represents a major manifestation, is involved aetiologically in a variety of clinical conditions including pregnancy and miscarriage 37 .…”

Section: Discussionmentioning

confidence: 99%

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Blood selenium and glutathione peroxidases in miscarriage

Zachara

Dobrzyński

Trafikowska

et al. 2001

BJOG

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Objective To investigate the selenium glutathione and glutathione peroxidase (glutathione-Px) levels in blood in women who experience miscarriage.Design An observational study. Participants Forty women with miscarriage occurring in the ®rst and second trimesters.Methods Concentrations were measured in whole blood and plasma. Glutathione was measured in red cells and glutathione-Px activity was measured in the red cells and plasma. The results were compared with 36 women in the same period of viable pregnancy and 28 age-matched, healthy, non-pregnant controls.Results The selenium concentrations in whole blood and plasma of women following abortion were the same as in viable pregnancy, but were signi®cantly lower compared with controls. The glutathione levels were significantly higher in women with miscarriage compared with viable pregnancies and with non-pregnant women.Red cell and plasma glutathione-Px activities of women who had had a miscarriage were signi®cantly lower than in both normal pregnancies and the control group. ConclusionThe decreased activities of the antioxidant enzymes, red cell and plasma glutathione-Px, may play an important role in the aetrology of spontaneous abortion.

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Selenium—Its biological perspectives

Cited by 64 publications

References 90 publications

Selenium Deficiency and Toxicity in the Environment

Selenium Deficiency and Toxicity in the Environment

Blood glutathione peroxidase and selenium in abortion

Blood selenium and glutathione peroxidases in miscarriage

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