Selenium as an important factor in various disease states - a review

Kieliszek, Marek; Bano, Iqra

doi:10.17179/excli2022-5137

Cited by 19 publications

(15 citation statements)

References 83 publications

(115 reference statements)

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“…The role of selenium in energy homeostasis is complex and the literature is full of somewhat contrasting data [ 189 , 371 , 372 ]. Conflicting reports could be the result of many variables, such as selenium status and confounding health conditions in the case of clinical studies, where patients were supplemented with selenium, as well as the specific form of selenium and the route of delivery used in animal studies.…”

Section: Discussionmentioning

confidence: 99%

Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication

Toh

Nicholson

Vetter

et al. 2022

IJMS

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The ability of the body to maintain homeostasis requires constant communication between the brain and peripheral tissues. Different organs produce signals, often in the form of hormones, which are detected by the hypothalamus. In response, the hypothalamus alters its regulation of bodily processes, which is achieved through its own pathways of hormonal communication. The generation and transmission of the molecules involved in these bi-directional axes can be affected by redox balance. The essential trace element selenium is known to influence numerous physiological processes, including energy homeostasis, through its various redox functions. Selenium must be obtained through the diet and is used to synthesize selenoproteins, a family of proteins with mainly antioxidant functions. Alterations in selenium status have been correlated with homeostatic disturbances in humans and studies with animal models of selenoprotein dysfunction indicate a strong influence on energy balance. The relationship between selenium and energy metabolism is complicated, however, as selenium has been shown to participate in multiple levels of homeostatic communication. This review discusses the role of selenium in the various pathways of communication between the body and the brain that are essential for maintaining homeostasis.

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Section: Discussionmentioning

confidence: 99%

Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication

Toh

Nicholson

Vetter

et al. 2022

IJMS

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“…Selenium adalah mikronutrien yang ditemukan dalam sereal, jamur, bawang merah, kacang-kacangan, brokoli, kubis, bawang putih, ikan, dan daging (Izgi et al, 2006;Sharma et al, 2017;Rayman, 2020;Kieliszek and Bano, 2022). Whanger (2002) dan Kieliszek (2019) menambahkan bahwa Selenomethionine (SeMet) merupakan asam amino alami yang ditemukan pada biji-bijian sereal, kedelai, dan tanaman leguminosa, sedangkan Se-methylselenocysteine, adalah bentuk utama Se yang ditemukan di Astragalus, Allium, dan rumput Brassica (Schrauzer, 2000).…”

Section: Review Sumber Se Dan Vitamin Eunclassified

Peran Selenium dan Vitamin E pada Ruminansia: ulasan singkat

Yanuartono,

Indarjulianto,

Paryuni

2024

jiiip

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Latar Belakang: Selenium (Se) adalah unsur yang umum terdapat di alam. Selenium ditemukan di dalam tanah dan diserap oleh tanaman pada tingkat yang berbeda-beda tergantung pada spesies tanaman, penggunaan pupuk, dan curah hujan, sedangkan vitamin E banyak terdapat pada tanaman leguminosa dan rumput segar. Selenium dan vitamin E merupakan elemen penting bagi ternak ruminansia dan diperlukan untuk untuk pertumbuhan normal dan membantu mencegah gangguan kesehatan lain. Peran kedua unsur tersebut memiliki kaitan yang erat karena mampu melindungi sel dari efek oksidasi yang merugikan meskipun memiliki mekanisme dengan cara yang berbeda. Kekurangan salah satu atau kedua unsur tersebut dapat menyebabkan penyakit white muscle disease, retensi plasenta, metritis, penurunan fungsi kekebalan tubuh, dan mastitis. Meskipun demikian, hasil penelitian maupun studi lapangan juga menunjukkan bahwa Se dan vitamin E dapat menimbulkan keracunan pada ruminansia. Reviews : Tulisan ini akan mengulas secara singkat dampak defisiensi dan toksisitas Se Vitamin E pada ruminansia.

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“…Selenium (DA: 55 mcg) is a trace element required for the activity of certain enzymes in the body, including glutathione peroxidase, which is necessary for the redox balance in the body, as well as deiodinase, necessary for the synthesis of the thyroid hormone [ 35 ]. Population-based and genetic studies have looked into the potential effects of selenium on the risk of cancer, or risk of mortality from cancer.…”

Section: Mineral Supplementsmentioning

confidence: 99%

“…Population-based and genetic studies have looked into the potential effects of selenium on the risk of cancer, or risk of mortality from cancer. Some studies have looked into the association of selenium supplement use with cancer recurrence and mortality, along with overall mortality [ 35 ]. In one study, 4459 men with non-metastatic prostate cancer were followed up for a median of 8.9 years.…”

Section: Mineral Supplementsmentioning

confidence: 99%

Supplement Use and Increased Risks of Cancer: Unveiling the Other Side of the Coin

Jabbari,

Yazdanpanah,

Benjamin

et al. 2024

Cancers

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There is a rising trend in the consumption of dietary supplements, especially among adults, with the purpose of improving health. While marketing campaigns tout the potential health benefits of using dietary supplements, it is critical to evaluate the potential harmful effects associated with these supplements as well. The majority of the scarce research on the potential harmful effects of vitamins focuses on the acute or chronic toxicities associated with the use of dietary supplements. Quality research is still required to further investigate the risks of long-term use of dietary supplements, especially the risk of developing cancers. The present review concentrates on studies that have investigated the association between the risk of developing cancers and associated mortality with the risk of dietary supplements. Such an association has been reported for several vitamins, minerals, and other dietary supplements. Even though several of these studies come with their own shortcomings and critics, they must draw attention to further investigate long-term adverse effects of dietary supplements and advise consumers and healthcare providers to ponder the extensive use of dietary supplements.

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Selenium as an important factor in various disease states - a review

Cited by 19 publications

References 83 publications

Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication

Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication

Peran Selenium dan Vitamin E pada Ruminansia: ulasan singkat

Supplement Use and Increased Risks of Cancer: Unveiling the Other Side of the Coin

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