Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation

Premanathan, Mariappan; Krishnamoorthy, Karthikeyan; Jeyasubramanian, K.; Manivannan, Govindasamy

doi:10.1016/j.nano.2010.10.001

Cited by 939 publications

(495 citation statements)

References 44 publications

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“…For example, PLLA/iron oxide nanocomposites have shown neurite extension in electrospun microfibers, Cai et al showed that PLLA/Fe 3 O 4 composites enhanced osteogenic differentiation [17] and in a similar way Dong et al showed enhanced osteogenic differentiation with PLLA/dicalcium silicate fibres. [18] In this context, ZnO NPs have attracted attention as antimicrobials [19,20] and UV blockers, [21] among others. Moreover, zinc is an essential element for cells, which acts as an intracellular secondary messenger in different cellular processes, [22,23] in particular, the lack of zinc can inhibit myoblast differentiation.…”

Section: Introductionmentioning

confidence: 99%

“…[26] ZnO NPs have demonstrated their preferential ability to kill high proliferative cells, like cancer cells, versus normal cells. [19,27] In addition, the oxidative stress properties of ZnO NPs have been also tested; [28] ZnO NPs can be sequestered by autophagy and this internalization could generate reactive oxygen species (ROS) intracellularly. [29] The effect of surfaces containing ZnO in cell behaviour has been investigated previously.…”

Section: Introductionmentioning

confidence: 99%

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PLLA/ZnO nanocomposites: Dynamic surfaces to harness cell differentiation

Trujillo

Lizundia

Vilas

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Graphical abstract2 Highlights  Biodegradable poly(L-lactide) matrix loaded with ZnO nanorods. Dynamic presentation of nanorods triggered by PLLA degradation. Changes in surface properties as a function of time control cell behaviour. Nanorods exposure promotes cell differentiation.3 Keywords: PLLA, ZnO nanoparticle, C2C12 myoblast, nanocomposite, cell differentiation AbstractThis work investigates the effect of the sequential availability of ZnO nanoparticles, (nanorods of ~ 20 nm) loaded within a degradable poly(lactic acid) (PLLA) matrix, in cell differentiation. The system constitutes a dynamic surface, in which nanoparticles are exposed as the polymer matrix degrades. ZnO nanoparticles were loaded into PLLA and the system was measured at different time points to characterise the time evolution of the physicochemical properties, including wettability and thermal properties. The micro and nanostructure were also investigated using AFM, SEM and TEM images. Cellular experiments with C2C12 myoblasts show that cell differentiation was significantly enhanced on ZnO nanoparticles -loaded PLLA, as the polymer degrades and the availability of nanoparticles become more apparent, whereas the release of zinc within the culture medium was negligible. Our results suggest PLLA/ZnO nanocomposites can be used as a dynamic system where nanoparticles are exposed during degradation, activating the material surface and driving cell differentiation.4

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

PLLA/ZnO nanocomposites: Dynamic surfaces to harness cell differentiation

Trujillo

Lizundia

Vilas

et al. 2016

Colloids and Surfaces B: Biointerfaces

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“…Following that NPs get internalized which then consequently results in oxidative DNA damage (Joshi et al, 2009;Premanathan et al, 2011). This kind of production of ROS has been observed in all types of living systems.…”

Section: Introductionmentioning

confidence: 99%

“…Researchers are focussing on therapeutical use of NPs to reduce treatment duration, flexibility in choosing administration route and for enhancing the activity of drugs, so that the drugs can be used even in case of deadly diseases like Tuberculosis (TB) Meena et al, 2010;Meena et al, 2013) and cancer (Park, et al, 2002;Hanley, et al, 2008;Premanathan, et al 2011). …”

Section: Introductionmentioning

confidence: 99%

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Meena¹,

Singh²,

Sahare³

et al. 2014

JLA

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The kind of interactions which nanoparticles show in the biological systems is very interesting. Nanoparticles (NPs) on entering the living system immediately come in contact with proteins which serve many applications of nanoparticles including bio-signalling, therapeutics and drug delivery systems. Moreover, many inorganic oxide nanoparticles can also serve the purpose of antibacterial/antiviral by assisting in the production of reactive oxygen species (ROS). The role of nanoparticles in therapeutics is very significant and increasing day-by-day as it assures better treatment to the patient by enhancing activity of drug, improving bioavailability, flexibility in deciding route of administration and long term stability of drug resulting in better treatments of diseases. NPs such as solid lipid NPs, polymeric NPs, porous NPs, liposomes are being used for treatment of various types of diseases. Numerous carriers based drug delivery systems incorporating anti-TB drugs have been developed for target site actions. NPs encapsulating anti-cancer drugs such as doxorubicin, paclitaxel have also been developed for treatment of different types of cancers. Results of these studies give hopes to the researchers for the use of nanoparticles in the field of therapeutics. The NPs can be toxic as well as nontoxic to the biological system. Therefore, some adverse effects, such as, cytotoxicity on inhaling some kinds of nanoparticles must be kept in mind for judicious use of such systems during synthesis or during handling. The paper describes recent developments in the field by reviewing the available literature.

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“…They are believed to destruct lipids and proteins of the bacterial cell membrane, resulting in a leakage of intracellular contents and eventually the death of bacterial cells [8]. ZnO-enriched surfaces are capable to inhibit the growth of bacteria [11]. They can also stimulate proliferation of osteoblasts, increase of alkaline phosphatase activity in these cells, synthesis and secretion of collagen and extracellular matrix mineralization [12].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Composite Layers on Ti: Role of ZnO Nanoparticles

Roguska

Belcarz

Suchecki

et al. 2016

Archives of Metallurgy and Materials

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Problem of Post-operative infections of implant materials caused by bacterial adhesion to their surfaces is very serious. Enhancement of antibacterial properties is potentially beneficial for biomaterials value. Therefore, the metallic and metallic oxide nanoparticles attract particular attention as antimicrobial factors. The aim of this work was to create nanotubular (NT) oxide layers on Ti with the addition of ZnO nanoparticles, designed for antibacterial biomedical coatings. Antimicrobial activities of titanium, TiO2NT and ZnO/TiO2NT surfaces were evaluated against bacterial strain typical for orthopaedic infections: S. epidermidis. TiO2NT alone killed the free bacterial cells significantly but promoted their adhesion to the surfaces. The presence of moderate amount of ZnO nanoparticles significantly reduced the S. epidermidis cells adhesion and viability of bacterial cells in contact with modified surfaces. However, higher amount of loaded nanoZnO showed the reduced antimicrobial properties than the medium amount, suggesting the overdose effect.

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Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation

Cited by 939 publications

References 44 publications

PLLA/ZnO nanocomposites: Dynamic surfaces to harness cell differentiation

PLLA/ZnO nanocomposites: Dynamic surfaces to harness cell differentiation

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Antibacterial Composite Layers on Ti: Role of ZnO Nanoparticles

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