Antibacterial Composite Layers on Ti: Role of ZnO Nanoparticles

Abstract

Problem of Post-operative infections of implant materials caused by bacterial adhesion to their surfaces is very serious. Enhancement of antibacterial properties is potentially beneficial for biomaterials value. Therefore, the metallic and metallic oxide nanoparticles attract particular attention as antimicrobial factors. The aim of this work was to create nanotubular (NT) oxide layers on Ti with the addition of ZnO nanoparticles, designed for antibacterial biomedical coatings. Antimicrobial activities of titanium, TiO2NT and ZnO/TiO2NT surfaces were evaluated against bacterial strain typical for orthopaedic infections: S. epidermidis. TiO2NT alone killed the free bacterial cells significantly but promoted their adhesion to the surfaces. The presence of moderate amount of ZnO nanoparticles significantly reduced the S. epidermidis cells adhesion and viability of bacterial cells in contact with modified surfaces. However, higher amount of loaded nanoZnO showed the reduced antimicrobial properties than the medium amount, suggesting the overdose effect.

Hybrid functionalized coatings on Metallic Biomaterials for Tissue Engineering

“…NPs, such as ZnO [193], HA [194] and Sr [195] for enhancing cytocompatibility and antibacterial properties.…”

Investigations into Ti-Based Metallic Alloys for Biomedical Purposes

“…For this purpose, there are several studies that estimate the relationship between the chemical composition and the microstructure of the surface, the physical-mechanical properties of biomaterials, the substrate and the coating material, and the properties of the human environment [13][14][15][16].…”