Selective sample preparation for determination of 11-nor-9-carboxy-.DELTA.9-tetrahydrocannabinol from human urine by gas chromatography with electron capture detection

Rosenfeld, Jack; Moharir, Yadu.; Sandler, Samuel

doi:10.1021/ac00183a030

Cited by 14 publications

(2 citation statements)

References 11 publications

(18 reference statements)

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“…An alternative approach to LLE derivatization is SPE derivatization, used in the past for cannabinoids, in which PFBBr is immobilized on the surface of styrene−divinylbenzene beads. ,− The beads “coated” with the derivatizing reagent are added to the liquid medium (e.g., urine or serum), and the analytes are derivatized and adsorbed on the surface of the beads. Next, the liquid phase is removed by aspiration, and the derivatized analytes are extracted from the beads using an organic solvent.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous Measurement of Urinary Bisphenol A and Alkylphenols by Automated Solid-Phase Extractive Derivatization Gas Chromatography/Mass Spectrometry

et al. 2003

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Bisphenol A (BPA) and alkylphenols (APs) are widely used industrial chemicals. BPA is used to manufacture polycarbonate plastic and epoxy resins; APs are used to make alkylphenol ethoxylates, common nonionic surfactants. BPA and APs can leach into the environment during industrial production and after degradation of the polycarbonate plastics and nonionic surfactants. Environmental exposure to these phenolic compounds has been associated with adverse reproductive and developmental effects in wildlife. We developed a sensitive and robust method for measuring BPA and six APs; 3-tert-butylphenol, 4-tert-butylphenol, 4-n-octylphenol, 4-tert-octylphenol, 4-n-nonylphenol, and technical-grade nonylphenol in urine. The method is based on the use of automated solid-phase extraction (SPE) coupled to isotope dilution-gas chromatography/mass spectrometry (GC/MS). During the automated SPE process, the phenols are both extracted from the urine matrix and derivatized, using pentafluorobenzyl bromide, on commercially available styrene-divinylbenzene copolymer-based SPE cartridges. After elution from the SPE column, the derivatized phenols in the SPE eluate are analyzed by GC/MS. The method, validated on spiked pooled urine samples and on urine samples from exposed persons, has limits of detection of approximately 0.1 ng in 1 mL of urine.

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Section: Resultsmentioning

confidence: 99%

Simultaneous Measurement of Urinary Bisphenol A and Alkylphenols by Automated Solid-Phase Extractive Derivatization Gas Chromatography/Mass Spectrometry

et al. 2003

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“…We [10,11,[13][14][15][16][17][18][19][20][21][22] and others [23][24][25][26][27][28][29] addressed these challenges by developing solid phase analytical derivatization (SPAD) of various analytes, including MDA [10,12,14], from biological samples. Recent work shows that SPAD facilitates simultaneous extraction/derivatization by producing faster reaction kinetics for AD particularly when the sorbent is configured in a column [11].…”

Section: Introductionmentioning

confidence: 99%

Determination of malondialdehyde in human plasma by fully automated solid phase analytical derivatization☆

Lord

Rosenfeld

Volovich

et al. 2009

Journal of Chromatography B

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Quantification of 9-Carboxy-11-nor-Δ9-tetrahydrocannabinol in Urine Using Brominated 9-Carboxy-11-nor-Δ9-tetrahydrocannabinol as the Internal Standard and High-Performance Liquid Chromatography with Electrochemical Detection

Fisher

Broudy

Fisher

1996

Biomed. Chromatogr.

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Selective sample preparation for determination of 11-nor-9-carboxy-.DELTA.9-tetrahydrocannabinol from human urine by gas chromatography with electron capture detection

Cited by 14 publications

References 11 publications

Simultaneous Measurement of Urinary Bisphenol A and Alkylphenols by Automated Solid-Phase Extractive Derivatization Gas Chromatography/Mass Spectrometry

Simultaneous Measurement of Urinary Bisphenol A and Alkylphenols by Automated Solid-Phase Extractive Derivatization Gas Chromatography/Mass Spectrometry

Determination of malondialdehyde in human plasma by fully automated solid phase analytical derivatization☆

Quantification of 9-Carboxy-11-nor-Δ9-tetrahydrocannabinol in Urine Using Brominated 9-Carboxy-11-nor-Δ9-tetrahydrocannabinol as the Internal Standard and High-Performance Liquid Chromatography with Electrochemical Detection

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