Selective potentiometric sensors for the determination of butenafine hydrochloride in a cream formulation

Frag, Eman Yossri; Mohamed, Mahmoud A.; Ebrahim, Mona Shehatta

doi:10.1016/j.microc.2020.104870

Cited by 8 publications

(10 citation statements)

References 11 publications

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“…From potential interfering chemical species, those were examined that are most often used as pharmaceutical excipients or those that are the most abundant in urine [ 37 , 44 , 54 ]. Additionally, the interfering influence of the essential amino acid arginine, non-essential amino acid cysteine, non-steroidal anti-inflammatory drugs, as well as the antidepressant trihexyphenydil hydrochloride, were examined.…”

Section: Resultsmentioning

confidence: 99%

“…ISEs are widely used primarily because of their simplicity, are relatively inexpensive, and significantly reduce analysis time compared to other techniques [ 30 ]. For the determination of the active ingredients of various pharmaceuticals, ISEs are usually prepared by incorporating the electroactive substances into polyvinyl chloride (PVC)-based membranes [ 3 , 24 , 31 , 32 , 33 , 34 , 35 , 36 ] or carbon paste membranes [ 35 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. Compared to PVC-based membranes, CPEs are not only faster and easier to fabricate, but also offer easier surface renewal, almost imperceptible ohmic resistance, and certainly more opportunities to modify the membrane composition to improve measurement selectivity [ 48 , 49 ].…”

Section: Introductionmentioning

confidence: 99%

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Potentiometric Determination of Maprotiline Hydrochloride in Pharmaceutical and Biological Matrices Using a Novel Modified Carbon Paste Electrode

Radić

Perović

Gričar

et al. 2022

Sensors

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Potentiometry with membrane selective electrodes is preferable for measuring the various constituents of pharmaceuticals. In this work, carbon paste electrodes (CPE) were prepared, modified, and tested for the determination of maprotiline hydrochloride, which acts as an antidepressant. The proposed CPE was based on an ionic association complex of maprotiline-tetraphenylborate, 2-nitrophenyloctyl as a binder, and sodium tetraphenylborate as an ionic lipophilic additive. The optimized composition improved potentiometric properties up to theoretical Nernst response values of −59.5 ± 0.8 mV dec−1, in the concentration range of maprotiline from 1.6 × 10−7 to 1.0 × 10−2 mol L−1, and a detection limit of 1.1 × 10−7 mol L−1. The CPE provides excellent reversibility and reproducibility, exhibits a fast response time, and is applicable over a wide pH range. No significant effect was observed in several interfering species tested. The proposed electrode was used for the precise determination of maprotiline in pure solutions, urine samples, and a real sample—the drug Ludiomil.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potentiometric Determination of Maprotiline Hydrochloride in Pharmaceutical and Biological Matrices Using a Novel Modified Carbon Paste Electrode

Radić

Perović

Gričar

et al. 2022

Sensors

View full text Add to dashboard Cite

show abstract

“…According to the literature, several compounds were included in the interference study because they are either a common excipient of the medications or an ion present in urine [ 36 , 41 , 59 ]. Interferences to some nonsteroidal anti-inflammatory analgesics as well as to an antidepressant were also tested.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, ion-selective electrodes have found applications in clinical, industrial, and environmental analysis [ 31 ]. One of the most common procedures for the development of ISE (for the determination of drugs, whether the active ingredient is a component of pharmaceutical preparations or biological fluids) is the incorporation of a lipophilic ion-pair-associated complex into a polyvinyl chloride (PVC) based membrane [ 31 , 32 , 33 , 34 , 35 ] or the preparation of carbon paste electrodes (CPE) [ 5 , 24 , 30 , 31 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

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A Novel Reduced Graphene Oxide Modified Carbon Paste Electrode for Potentiometric Determination of Trihexyphenidyl Hydrochloride in Pharmaceutical and Biological Matrices

Radić

Buljac

Genorio

et al. 2021

Sensors

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A novel promising carbon paste electrode with excellent potentiometric properties was prepared for the analysis of trihexyphenidyl hydrochloride (THP), the acetylcholine receptor and an anticholinergic drug in real samples. It contains 10.2% trihexyphenidy-tetraphenylborate ionic pair as the electroactive material, with the addition of 3.9% reduced graphene oxide and 0.3% of anionic additive into the paste, which consists of 45.0% dibutylphthalate as the solvent mediator and 40.6% graphite. Under the optimized experimental conditions, the electrode showed a Nernstian slope of 58.9 ± 0.2 mV/decade with a regression coefficient of 0.9992. It exhibited high selectivity and reproducibility as well as a fast and linear dynamic response range from 4.0 × 10−7 to 1.0 × 10−2 M. The electrode remained usable for up to 19 days. Analytical applications showed excellent recoveries ranging from 96.8 to 101.7%, LOD was 2.5 × 10−7 M. The electrode was successfully used for THP analysis of pharmaceutical and biological samples.

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Sensitive and effective electrochemical determination of butenafine in the presence of itraconazole using titanium nanoparticles-ionic liquid based nanocomposite sensor

et al. 2022

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The evaluation of the bioavailability of topically applied medications that act inside or under the skin is a challenging task. Herein, the current study describes a simple, quick, and low-cost electrochemical platform for determining butenafine hydrochloride (BTH) that is mainly prescribed as a treatment of dermatophytosis, applying titanium nanoparticles and an ionic liquid as outstanding mediators. In terms of low detection limits (61.63 nM) and extensive range of 2.21 × 10–7–13.46 × 10–5 M, the established electrochemical technique provided worthy analytical performance for butenafine hydrochloride sensing. The suggested sensor's practical applicability was effectively demonstrated in pharmaceutical preparations, actual stratum corneum samples, and simultaneous detection of butenafine hydrochloride and Itraconazole in pharmaceutical preparation for the first time. All of the experimental factors, like the pH and scan rate, have been investigated and optimized. Diffusion coefficients of butenafine hydrochloride at bare and modified sensors were calculated.

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Selective potentiometric sensors for the determination of butenafine hydrochloride in a cream formulation

Cited by 8 publications

References 11 publications

Potentiometric Determination of Maprotiline Hydrochloride in Pharmaceutical and Biological Matrices Using a Novel Modified Carbon Paste Electrode

Potentiometric Determination of Maprotiline Hydrochloride in Pharmaceutical and Biological Matrices Using a Novel Modified Carbon Paste Electrode

A Novel Reduced Graphene Oxide Modified Carbon Paste Electrode for Potentiometric Determination of Trihexyphenidyl Hydrochloride in Pharmaceutical and Biological Matrices

Sensitive and effective electrochemical determination of butenafine in the presence of itraconazole using titanium nanoparticles-ionic liquid based nanocomposite sensor

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