Selective photothermolysis of lipid-rich tissues: A free electron laser study

Anderson, R. Rox; Farinelli, William A.; Laubach, Hans; Manstein, Dieter; Yaroslavsky, Anna N.; Gubeli, J.; Jordan, K.; Neil, George; Shinn, Michelle D.; Chandler, W. K.; Williams, Gwyn; Benson, Steven V.; Douglas, D.; Dylla, H. F.

doi:10.1002/lsm.20393

Cited by 211 publications

(182 citation statements)

References 21 publications

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“…This method has been described in the literature for identifying thermally affected tissue both in vivo as well as for ex vivo studies [19][20][21]. Viable tissue stains blue and TIZs are demarcated by a pale color or lack of blue staining.…”

Section: Ius Exposure Proceduresmentioning

confidence: 99%

Selective transcutaneous delivery of energy to porcine soft tissues using intense ultrasound (IUS)

White

Makin²,

Slayton³

et al. 2008

Lasers Surg Med

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Objective: Various energy delivery systems have been utilized to treat superficial rhytids in the aging face. The Intense Ultrasound System (IUS) is a novel modality capable of transcutaneously delivering controlled thermal energy at various depths while sparing the overlying tissues. The purpose of this feasibility study was to evaluate the response of porcine tissues to various IUS energy source conditions. Further evaluation was performed of the built-in imaging capabilities of the device. Materials and Methods: Simulations were performed on ex vivo porcine tissues to estimate the thermal dose distribution in tissues after IUS exposures to determine the unique source settings that would produce thermal injury zones (TIZs) at given depths. Exposures were performed at escalating power settings and different exposure times (in the range of 1-7.6 J) using three IUS handpieces with unique frequencies and focal depths. Ultrasound imaging was performed before and after IUS exposures to detect changes in tissue consistency. Porcine tissues were examined using nitro-blue tetrazolium chloride (NBTC) staining sensitive for thermal lesions, both grossly and histologically. The dimensions and depth of the TIZs were measured from digital photographs and compared. Results: IUS can reliably achieve discrete, TIZ at various depths within tissue without surface disruption. Changes in the TIZ dimensions and shape were observed as source settings were varied. As the source energy was increased, the thermal lesions became larger by growing proximally towards the tissue surface. Maximum lesion depth closely approximated the pre-set focal depth of a given handpiece. Ultrasound imaging detected well-demarcated TIZ at depths within the porcine muscle tissue. Conclusion: This study demonstrates the response of porcine tissue to various energy dose levels of Intense Ultrasound. Further study, especially on human facial tissue, is necessary in order to understand the utility of this modality in treating the aging face and potentially, other cosmetic applications.

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Section: Ius Exposure Proceduresmentioning

confidence: 99%

Selective transcutaneous delivery of energy to porcine soft tissues using intense ultrasound (IUS)

White

Makin²,

Slayton³

et al. 2008

Lasers Surg Med

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“…The short-wave (SWIR) (1700-2500 nm) and the mid-infrared (MIR) are becoming key wavelength regions for a large number of applications, such as gas sensing [1], free space communication [2] , medical diagnostic and surgery [3]. Moreover, laser sources around 2 micron can be employed for pumping nonlinear media to convert telecom signals in the MIR through four-wave mixing (FWM).…”

Section: Introductionmentioning

confidence: 99%

Small core Chalcogenide photonic crystal fiber for mid-infrared wavelength conversion: experiment and design

Xing

Grassani

Kharitonov

et al. 2016

Conference on Lasers and Electro-Optics

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“…15,40,41 The combined IVUS/IVPA imaging of lipids has been successfully demonstrated at the wavelengths 1210 nm 13,19 and at 1720 nm 28 where the optical absorption coefficient of lipid exceeds that of water. 42 Combined IVUS/ IVPA imaging of ex vivo lipid-rich plaques in the presence of whole blood in the forward imaging mode 4 and using integrated IVUS/IVPA imaging catheter 28 has been achieved. While using the absorption band around 1210 nm required a sophisticated, time-consuming spectroscopic IVPA imaging even with saline in a lumen, 19 absorption band around 1720 nm is significantly higher and offers a prospect of a single wavelength imaging.…”

Section: Discussionmentioning

confidence: 99%

“…28 Indeed, while the effective attenuation coefficient in blood at 1720 nm is approximately 2.2 times greater than that at 1210 nm, the light absorption coefficient of lipid at 1720 nm is around five time greater that at 1210 nm thus increasing the photoacoustic contrast at 1720 nm and eliminating a need to suppress nonlipid background IVPA signals. 25,42 Overall, the reported prototype of the integrated IVUS/IVPA imaging catheter is based on an optical fiber capable of delivering light in the wide spectral range from 380 to 2400 nm which makes it suitable for all these intravascular applications.…”

Section: Discussionmentioning

confidence: 99%

Feasibility ofin vivointravascular photoacoustic imaging using integrated ultrasound and photoacoustic imaging catheter

et al. 2012

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Abstract. Pilot studies of in vivo combined intravascular ultrasound (IVUS) and intravascular photoacoustic (IVPA) imaging are reported. A recently introduced prototype of an integrated IVUS/IVPA imaging catheter consisting of a single-element ultrasound transducer and a light delivery system based on a single optical fiber was adapted and used for in vivo imaging of a coronary stent deployed in a rabbit's thoracic aorta in the presence of luminal blood. The results suggest that in vivo IVUS/IVPA imaging is feasible using the integrated IVUS/IVPA imaging catheter. The challenges of in vivo combined IVUS/IVPA imaging are discussed, and further improvements on the design of the catheter and the clinical imaging system are proposed.

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Selective photothermolysis of lipid-rich tissues: A free electron laser study

Abstract: Selective photothermal targeting of fatty tissues is feasible using infrared lipid absorption bands. Potential clinical applications are suggested by this FEL study.

Cited by 211 publications

References 21 publications

Selective transcutaneous delivery of energy to porcine soft tissues using intense ultrasound (IUS)

Selective transcutaneous delivery of energy to porcine soft tissues using intense ultrasound (IUS)

Small core Chalcogenide photonic crystal fiber for mid-infrared wavelength conversion: experiment and design

Feasibility ofin vivointravascular photoacoustic imaging using integrated ultrasound and photoacoustic imaging catheter

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