Feasibility of<i>in vivo</i>intravascular photoacoustic imaging using integrated ultrasound and photoacoustic imaging catheter

Karpiouk, Andrei; Wang, Bo; Amirian, James; Smalling, Richard W.; Emelianov, Stanislav

doi:10.1117/1.jbo.17.9.096008

Cited by 42 publications

(35 citation statements)

References 43 publications

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“…1(a)], we were able to achieve a rigid distal section length of only 16-mm, two times shorter than the previous micromotor-based endoscope 18 and to enable the catheter section to pass freely through the 3.7-mm diameter entry port of a video endoscope. Although other PA endoscopic systems [20][21][22][23][24] have been implemented with a similar proximal actuation mechanism, their imaging probes are not sheathed in a plastic tube and/or their in vivo imaging capabilities have not been demonstrated. We believe that the presented PAE system is the first PA endoscopic system that has been implemented in a fully encapsulated form and sufficiently miniaturized to be usable for endoscopic imaging via the standard instrument channel of a clinical video endoscope.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] So far, the clinical potential of the technique has been investigated in various endoscopic areas. [15][16][17][18][19][20][21][22][23][24][25][26] However, the development of associated imaging devices is still at an immature stage because of technical challenges. Unlike existing ultrasonic (US) 27,28 or optical endoscopic probes, [29][30][31][32][33][34][35][36][37] PA endoscopy (PAE) requires the integration of both optical and acoustic elements in a small space.…”

Section: Introductionmentioning

confidence: 99%

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Catheter-based photoacoustic endoscope

Yang

Chen

et al. 2014

J. Biomed. Opt.

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Abstract. We report a flexible shaft-based mechanical scanning photoacoustic endoscopy (PAE) system that can be potentially used for imaging the human gastrointestinal tract via the instrument channel of a clinical video endoscope. The development of such a catheter endoscope has been an important challenge to realize the technique's benefits in clinical settings. We successfully implemented a prototype PAE system that has a 3.2-mm diameter and 2.5-m long catheter section. As the instrument's flexible shaft and scanning tip are fully encapsulated in a plastic catheter, it easily fits within the 3.7-mm diameter instrument channel of a clinical video endoscope. Here, we demonstrate the intra-instrument channel workability and in vivo animal imaging capability of the PAE system.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Catheter-based photoacoustic endoscope

Yang

Chen

et al. 2014

J. Biomed. Opt.

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“…Moreover, this also allows for using US imaging information for improvements of the PA image, such as in displacement compensated averaging [6]. Hybrid PA/US imaging devices have also been demonstrated for intravascular imaging, using an imaging catheter [7]. All the mentioned implementations have in common that the used devices are rather optimized for US than for PA imaging.…”

Section: Introductionmentioning

confidence: 99%

Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection

Nuster

Schmitner

Wurzinger

et al. 2013

Journal of Biophotonics

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Journal of BIOPHOTONICSA setup is proposed that provides perfectly co-registered photoacoustic (PA) and ultrasound (US) section images. Photoacoustic and ultrasound backscatter signals are generated by laser pulses coming from the same laser system, the latter by absorption of some of the laser energy on an optically absorbing target near the imaged object. By measuring both signals with the same optical detector, which is focused into the selected section by use of a cylindrical acoustic mirror, the information for both images is acquired simultaneously. Co-registered PA and US images are obtained after applying the inverse Radon transform to the data, which are gathered while rotating the object relative to the detector. Phantom experiments demonstrate a resolution of 1.1 mm between the sections of both imaging modalities and a inplane resolution of about 60 mm and 120 mm for the US and PA modes, respectively. The complementary contrast mechanisms of the two modalities are shown by images of a zebrafish.Result of the dual-modality section imaging experiment on a zebrafish. Scale bar: 1 mm. The first row shows the photoacoustic (PA) and the laser ultrasound (LUS) section image. The second row shows the fusion image (FI) and the histological section.

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“…[28][29][30][31] Such probes are being developed and tested by other groups with the ultimate goal of clinical translation. 29,[32][33][34][35] In summary, this study demonstrated that PA imaging offers excellent spatial resolution, penetration, and contrast for tracking transport of a drug surrogate in the porcine vasculature. PAIS also improves the specificity for estimating drug concentrations by separating the signal from intrinsic background absorbers in cardiac tissue.…”

Section: Ultrasound and Photoacoustic Imaging Of A Dii-coated Stentmentioning

confidence: 99%

Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy

2017

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, "Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy," J. Biomed. Opt. 22(4), 041016 (2017), doi: 10.1117/1.JBO.22.4.041016. Abstract. Although the drug-eluting stent (DES) has dramatically reduced the rate of coronary restenosis, it still occurs in up to 20% of patients with a DES. Monitoring drug delivery could be one way to decrease restenosis rates. We demonstrate real-time photoacoustic imaging and spectroscopy (PAIS) using a wavelength-tunable visible laser and clinical ultrasound scanner to track cardiac drug delivery. The photoacoustic signal was initially calibrated using porcine myocardial samples soaked with a known concentration of a drug surrogate (DiI). Next, an in situ coronary artery was perfused with DiI for 20 min and imaged to monitor dye transport in the tissue. Finally, a partially DiI-coated stent was inserted into the porcine brachiocephalic trunk for imaging. The photoacoustic signal was proportional to the DiI concentration between 2.4 and 120 μg∕ml, and the dye was detected over 1.5 mm from the targeted coronary vessel. Photoacoustic imaging was also able to differentiate the DiI-coated portion of the stent from the uncoated region. These results suggest that PAIS can track drug delivery to cardiac tissue and detect drugs loaded onto a stent with sub-mm precision. Future work using PAIS may help improve DES design and reduce the probability of restenosis.

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Feasibility ofin vivointravascular photoacoustic imaging using integrated ultrasound and photoacoustic imaging catheter

Cited by 42 publications

References 43 publications

Catheter-based photoacoustic endoscope

Catheter-based photoacoustic endoscope

Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection

Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy

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