Selective laser melting of Ti alloys and hydroxyapatite for tissue engineering: progress and challenges

Jaber, Hassanen; Kovács, Tünde Anna

doi:10.1088/2053-1591/ab1dee

Cited by 26 publications

(13 citation statements)

References 113 publications

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“…The loading conditions of the four groups of scaffolds were exactly the same, and the static characteristics of each group of scaffolds were calculated and compared. In the simulation process, the bone scaffold material is Ti6Al4V, material parameters as shown in Table 1 [ 23 , 24 ].…”

Section: Methodsmentioning

confidence: 99%

Study on mechanical properties and permeability of elliptical porous scaffold based on the SLM manufactured medical Ti6Al4V

Shi

Qin

et al. 2021

PLoS ONE

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In this paper, we take the elliptical pore structure which is similar to the microstructure of cancellous bone as the research object, four groups of bone scaffolds were designed from the perspective of pore size, porosity and pore distribution. The size of the all scaffolds were uniformly designed as 10 × 10 × 12 mm. Four groups of model samples were prepared by selective laser melting (SLM) and Ti6Al4V materials. The statics performance of the scaffolds was comprehensively evaluated by mechanical compression simulation and mechanical compression test, the manufacturing error of the scaffold samples were evaluated by scanning electron microscope (SEM), and the permeability of the scaffolds were predicted and evaluated by simulation analysis of computational fluid dynamics (CFD). The results show that the different distribution of porosity, pore size and pores of the elliptical scaffold have a certain influence on the mechanical properties and permeability of the scaffold, and the reasonable size and angle distribution of the elliptical pore can match the mechanical properties and permeability of the elliptical pore scaffold with human cancellous bone, which has great potential for research and application in the field of artificial bone scaffold.

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Section: Methodsmentioning

confidence: 99%

Study on mechanical properties and permeability of elliptical porous scaffold based on the SLM manufactured medical Ti6Al4V

Shi

Qin

et al. 2021

PLoS ONE

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“…In addition, based on the additive manufacturing process of HA and Ti, it has been reported and verified that the composite is thermally stable with a good biological performance below a sintering temperature of 800°C. 63–65 Because of the biocompatibility of HA, it is desirable to have HA at the bottom surface of the bone plate, which is attached to the bone.…”

Section: Resultsmentioning

confidence: 99%

Optimal three-dimensional design of functionally graded parts for additive manufacturing using Tamura–Tomota–Ozawa model

Nayak

Armani

2021

Proceedings of the Institution of Mechanical Engineers, Part L:

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Although some conventional manufacturing technologies are capable of producing functionally graded materials, only a few additive manufacturing processes are able to build functionally graded materials with complex distribution of material composition. To exploit this unique advantage, we have developed a new methodology capable of optimization of material distribution for three-dimensional parts for any given conditions. Representation of material distribution was done through a new technique by extending the nonuniform rational basis spline surfaces to four-dimensional space. Mori–Tanaka, Levin, and Tamura–Tomota–Ozawa models were employed for the estimation of effective material properties of functionally graded structures. Subroutines were developed in a commercial finite element software to enable the analysis of parts made from functionally graded material. A constrained particle swarm optimization method was selected and implemented to optimize the material composition distribution taking into account the additive manufacturing limitations. As a case study, the material distribution optimization of a functionally graded femur bone plate under thermomechanical loading was considered. The objective was to maximize the safety factor; i.e. the ratio of local yield strength of the functionally graded plate over the von Mises stress. The results showed significant improvement compared to nonoptimal part and demonstrated the efficacy of the proposed methodology.

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“…The main input parameters include layer thickness, scanning speed, laser power, etc. These parameters will affect the energy density of the laser beam in the melted powder layer and finally affect the quality of the final product [ 40 ]. Scientists use these differences to meet the needs of different tissue-engineered scaffolds.…”

Section: Several Different 3d Printing Technologiesmentioning

confidence: 99%

Applications of 3D printed bone tissue engineering scaffolds in the stem cell field

Wang

Guo

2021

Regenerative Therapy

120

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Due to traffic accidents, injuries, burns, congenital malformations and other reasons, a large number of patients with tissue or organ defects need urgent treatment every year. The shortage of donors, graft rejection and other problems cause a deficient supply for organ and tissue replacement, repair and regeneration of patients, so regenerative medicine came into being. Stem cell therapy plays an important role in the field of regenerative medicine, but it is difficult to fill large tissue defects by injection alone. The scientists combine three-dimensional (3D) printed bone tissue engineering scaffolds with stem cells to achieve the desired effect. These scaffolds can mimic the extracellular matrix (ECM), bone and cartilage, and eventually form functional tissues or organs by providing structural support and promoting attachment, proliferation and differentiation. This paper mainly discussed the applications of 3D printed bone tissue engineering scaffolds in stem cell regenerative medicine. The application examples of different 3D printing technologies and different raw materials are introduced and compared. Then we discuss the superiority of 3D printing technology over traditional methods, put forward some problems and limitations, and look forward to the future.

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Selective laser melting of Ti alloys and hydroxyapatite for tissue engineering: progress and challenges

Cited by 26 publications

References 113 publications

Study on mechanical properties and permeability of elliptical porous scaffold based on the SLM manufactured medical Ti6Al4V

Study on mechanical properties and permeability of elliptical porous scaffold based on the SLM manufactured medical Ti6Al4V

Optimal three-dimensional design of functionally graded parts for additive manufacturing using Tamura–Tomota–Ozawa model

Applications of 3D printed bone tissue engineering scaffolds in the stem cell field

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