Applications of 3D printed bone tissue engineering scaffolds in the stem cell field

Su, Xin; Wang, Ting; Guo, Shu

doi:10.1016/j.reth.2021.01.007

Cited by 123 publications

(82 citation statements)

References 90 publications

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“…65,66 Among them, a simple and efficient process is lyophilisation, which starts with freezing a solution of chitosan with or without additives followed by evaporation of the solvent under reduced pressure. 67,68 At present, there are numerous techniques available to fabricate a chitosan-based membrane or scaffold for tissue engineering such as particle salt leaching, 69,70 electrospinning, 71,72 stereolithography, 73,74 gas foaming, 75,76 freeze-drying, 57,67,75 and 3D bioprinting. [77][78][79][80] Electrospinning is a simple, straightforward, and costeffective technique for producing nanofibers.…”

Section: Chitosan-based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

“…At present, there are numerous techniques available to fabricate a chitosan‐based membrane or scaffold for tissue engineering such as particle salt leaching, 69,70 electrospinning, 71,72 stereolithography, 73,74 gas foaming, 75,76 freeze‐drying, 57,67,75 and 3D bioprinting 77–80 . Electrospinning is a simple, straightforward, and cost‐effective technique for producing nanofibers.…”

Section: Chitosan‐based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

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Chitosan‐based nanocomposites for medical applications

Murugesan

Scheibel

2021

Journal of Polymer Science

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Chitosan as a biobased polymer is gaining increasing attention due to its extraordinary physico-chemical characteristics and properties. While a primary use of chitosan has been in horticultural and agricultural applications for plant defense and to increase crop yield, recent research reports display various new utilizations in the field of advanced biomedical devices, targeted drug delivery, and as bioimaging sensors. Chitosan possesses multiple characteristics such as antimicrobial properties, stimuli-responsiveness, tunable mechanical strength, biocompatibility, biodegradability, and water-solubility. Further, chitosan can be processed into nanoparticles, nano-vehicles, nanocapsules, scaffolds, fiber meshes, and 3D printed scaffolds for a variety of applications. In recent times, nanoparticles incorporated in chitosan matrices have been identified to show superior biological activity, as cells tend to proliferate/differentiate faster when they interact with nanocomposites rather than bulk or micron size substrates/scaffolds. The present article intents to cover chitosan-based nanocomposites used for regenerative medicine, wound dressings, drug delivery, and biosensing applications.

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Section: Chitosan-based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Section: Chitosan‐based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Chitosan‐based nanocomposites for medical applications

Murugesan

Scheibel

2021

Journal of Polymer Science

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“…The biomaterials are selected according to the soft and hard types of tissue for tissue regeneration and repair, as depicted in Figure 39. The AM techniques are commonly used for scaffold fabrication for soft tissue such as cardiovascular, cartilage, neural, liver, skin and hard tissue like bone and dental (Maity, 2018;Janmohammadi and Nourbakhsh, 2020;Venkatesan et al, 2020;Beheshtizadeh et al, 2020;Fayyazbakhsh and Leu, 2020;Mazzoni et al, 2021;Su et al, 2021).…”

Section: Biomaterials For Soft and Hard Tissuesmentioning

confidence: 99%

Additive manufacturing techniques for the fabrication of tissue engineering scaffolds: a review

Kumar

Sharma

2021

RPJ

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Purpose Additive manufacturing (AM) or solid freeform fabrication (SFF) technique is extensively used to produce intrinsic 3D structures with high accuracy. Its significant contributions in the field of tissue engineering (TE) have significantly increased in the recent years. TE is used to regenerate or repair impaired tissues which are caused by trauma, disease and injury in human body. There are a number of novel materials such as polymers, ceramics and composites, which possess immense potential for production of scaffolds. However, the major challenge is in developing those bioactive and patient-specific scaffolds, which have a required controlled design like pore architecture with good interconnectivity, optimized porosity and microstructure. Such design not only supports cell proliferation but also promotes good adhesion and differentiation. However, the traditional techniques fail to fulfill all the required specific properties in tissue scaffold. The purpose of this study is to report the review on AM techniques for the fabrication of TE scaffolds. Design/methodology/approach The present review paper provides a detailed analysis of the widely used AM techniques to construct tissue scaffolds using stereolithography (SLA), selective laser sintering (SLS), fused deposition modeling (FDM), binder jetting (BJ) and advanced or hybrid additive manufacturing methods. Findings Subsequently, this study also focuses on understanding the concepts of TE scaffolds and their characteristics, working principle of scaffolds fabrication process. Besides this, mechanical properties, characteristics of microstructure, in vitro and in vivo analysis of the fabricated scaffolds have also been discussed in detail. Originality/value The review paper highlights the way forward in the area of additive manufacturing applications in TE field by following a systematic review methodology.

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“…However, it should be recognised that such printed or bioprinted implants could also be loaded with cells prior to implantation in a clinical setting and still be classified a print-and-implant strategy. Extensive reviews are available in the literature on cell sources for bone regeneration in general [23][24][25][26][27] and more specifically for bioprinting bone implants [9,10,[28][29][30][31][32][33][34][35].…”

Section: Print-and-implant Strategies That Harness Bone's Inherent Reparative Capacitymentioning

confidence: 99%

Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors

Freeman

Burdis²,

Kelly³

2021

Trends in Molecular Medicine

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Regenerating large bone defects remains a significant clinical challenge, motivating increased interest in additive manufacturing and 3D bioprinting to engineer superior bone graft substitutes. 3D bioprinting enables different biomaterials, cell types, and growth factors to be combined to develop patientspecific implants capable of directing functional bone regeneration. Current approaches to bioprinting such implants fall into one of two categories, each with their own advantages and limitations. First are those that can be 3D bioprinted and then directly implanted into the body and second those that require further in vitro culture after bioprinting to engineer more mature tissues prior to implantation. This review covers the key concepts, challenges, and applications of both strategies to regenerate damaged and diseased bone. Current Bioprinting Strategies for Bone RegenerationSince the first US patent was awarded for 3D bioprinting (see Glossary) in 2006 (https://www.google.com/patents/US7051654), there have been significant advances in the field, particularly its application towards bone regeneration. This can be seen in the large number of publications (>600 papers) and reviews [1][2][3][4][5][6][7][8][9][10][11][12] devoted to the topic in the past 4 years alone. Advances in additive manufacturing and 3D bioprinting have had a significant impact on the fields of tissue engineering and regenerative medicine, with microextrusion, inkjet, laser-assisted bioprinting, and more recently melt-electrowriting (MEW) techniques all being used to generate implants for bone repair. In the literature there are a variety of definitions for the terms 'bioprinting' and 'bioinks', with some specifying the presence of cells as a mandatory component of the printing formulation in bioprinting [13]. For the purpose of this review, we define bioprinting as the use of 3D printing technologies to deposit cells and/or other biological factors, specifically genes, growth factors, and/or extracellular matrix (ECM) components, in a spatially controlled pattern to fabricate or regenerate living tissues and organs. Common features of a bone bioprinting strategy include a bioink (typically a hydrogel), laden with cells, genes, and/or growth factors, and a mechanical backbone of a thermopolymer or ceramic to accommodate the challenging loads experienced by the implant in situ. Extensive reviews have been written on the various technologies [1,2,4,5,[9][10][11][12][14][15][16][17] and bioinks [1,3,[6][7][8]10,18,19] under development for bone regeneration. Broadly speaking, putative therapeutics that can be derived from such technologies fall into one of two categories; first, those that can be 3D bioprinted and then directly implanted into the body (herein termed 'print-and-implant' devices), and second, those that require further in vitro culture after bioprinting (e.g., in a bioreactor) to mature the engineered tissue prior to implantation. Both approaches have their own inherent advantages and limitations. Constructs that can be biopri...

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Applications of 3D printed bone tissue engineering scaffolds in the stem cell field

Cited by 123 publications

References 90 publications

Chitosan‐based nanocomposites for medical applications

Chitosan‐based nanocomposites for medical applications

Additive manufacturing techniques for the fabrication of tissue engineering scaffolds: a review

Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors

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