Selective inhibitors for phosphodiesterase 3 and 4 in antigen-induced increase of cough reflex sensitivity in guinea pigs

Fujimura, Masaki; Liu, Qi

doi:10.1016/j.pupt.2006.05.004

Cited by 8 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bronchodilation and an anti-inflammatory action of non-selective PDE inhibitors has been only partially elucidated and little is known about the antitussive effects of xanthine derivatives (Mokry et al ., 2008) or selective PDE inhibitors (PDE3, PDE4, PDE5) (Fujimura and Liu, 2007). Selective inhibitors of PDE have attracted increasing attention in the therapy of respiratory diseases (Chung, 2006).…”

Section: Hyperreactivity Of Airways and Phosphodiesterase (Pde) Inhibmentioning

confidence: 99%

Pharmacologic modulation of experimentally induced allergic asthma

Fraňová¹,

Strapková²,

Mokrý³

et al. 2011

Interdisciplinary Toxicology

View full text Add to dashboard Cite

Allergic asthma is the most frequent disease of the respiratory tract. The aim of the current experimental and clinical studies was to find new sources of drugs able to control asthmatic inflammation and airway hyperresponsiveness. Our experimental studies were focused on efficiency evaluation of substances able to influence activities of ion channels, phosphodiesterase (PDE) isoforms, substances from the group of polyphenols and NO metabolism modulators during experimentally induced allergic asthma.

show abstract

Section: Hyperreactivity Of Airways and Phosphodiesterase (Pde) Inhibmentioning

confidence: 99%

Pharmacologic modulation of experimentally induced allergic asthma

Fraňová¹,

Strapková²,

Mokrý³

et al. 2011

Interdisciplinary Toxicology

View full text Add to dashboard Cite

show abstract

“…Similarly, the effects of cilomilast and of a selective phosphodiesterase 3 inhibitor olprinone on capsaicin-induced cough in antigen-sensitized guinea pigs were assessed and cilomilast, but not olprinone, improved capsaicin cough sensitivity and airway eosinophilia [61]. However, phosphodiesterase 3 inhibitors such as cilostazol could be potentially effective as CVA therapy, as in elderly subjects with asthma and cough as the main respiratory symptom, it significantly improved cough-reflex sensitivity to capsaicin as compared with placebo [62].…”

Section: Other Therapies and Potential Therapeutic Targetsmentioning

confidence: 99%

Pharmacotherapy of cough-variant asthma

Antoniu

Mihăescu

Donner

2007

Expert Opinion on Pharmacotherapy

View full text Add to dashboard Cite

Cough-variant asthma is considered as an asthma subset in which chronic cough is the only symptom. It is believed to be more frequent and, hence, sometimes overdiagnosed in children, and shares with typical asthma eosinophilic airway inflammation and consequent bronchial hyper-responsiveness. Presently available therapies consist of bronchodilators, inhaled or oral corticosteroids, or leukotriene modifiers. However, the long-term efficacy of these agents in adults and children is not known. This review focuses on current therapies used for cough variant asthma, also highlighting potential therapeutic targets for this condition.

show abstract

Effects of Selective Inhibition of PDE4 by YM976 on Airway Reactivity and Cough in Ovalbumin-Sensitized Guinea Pigs

Mokrý

Urbanová

Medvedova

et al. 2016

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Phosphodiesterases (PDEs) are enzymes involved in the degradation of cAMP and cGMP. Selective PDE4 inhibitors (e.g., roflumilast) are effective in therapy of chronic obstructive pulmonary disease associated with neutrophil inflammation. The aim of this study was to evaluate the effects of a selective PDE4 inhibitor, YM976, on citric acid-induced cough, in vivo and in vitro airway smooth muscle reactivity to histamine, and on inflammatory mediators in ovalbumin-sensitized guinea pigs, with experimentally induced eosinophil inflammation. The YM976 was administered intraperitoneally at a dose of 1.0 mg/kg once daily for 7 days. Sensitization with ovalbumin led to a significant increase in the number of coughs, and in vivo and in vitro airway reactivity. Also, increased plasma levels of IL-4, IL-5, and PAF were observed, with a significant increase in the differential count of eosinophils in both blood and bronchoalveolar lavage fluid. The YM976 suppressed the number of coughs, the airway reactivity in tracheal tissue strips, and the IL-4 level. The findings indicate that PDE4 inhibition by YM976 exerts antitussive and anti-inflammatory effects in guinea pigs with ovalbumin-induced eosinophilic inflammation.

show abstract

Selective inhibitors for phosphodiesterase 3 and 4 in antigen-induced increase of cough reflex sensitivity in guinea pigs

Cited by 8 publications

References 25 publications

Pharmacologic modulation of experimentally induced allergic asthma

Pharmacologic modulation of experimentally induced allergic asthma

Pharmacotherapy of cough-variant asthma

Effects of Selective Inhibition of PDE4 by YM976 on Airway Reactivity and Cough in Ovalbumin-Sensitized Guinea Pigs

Contact Info

Product

Resources

About